GLAUCIUS OLIVA is Full Professor of the University of São Paulo. He studied Physics and Electronics Engineering as an undergraduate of the University of São Paulo and subsequently obtained his PhD in Protein Crystallography and Structural Biology at the University of London in 1988l. His main research interests are structural biology and medicinal chemistry and its application in drug design and discovery, with a particular focus on parasitic infectious tropical diseases that affect the population of Brazil and other developing countries. His work on Chagas disease has led to the discovery of several new inhibitors of parasitic enzymes, promising new drugs for the treatment of this endemic illness. He was the key leader in the establishment of Protein Crystallography research in Brazil, including the development of the first protein crystallography beamline at the Brazilian National Synchrotron Laboratory. He has lead the first graduate program on Biomolecular Physics in the country and more recently created the first undergraduate course on Biomolecular Physical Sciences in Brazil. He was Vice-president of the Brazilian Society of Biochemistry and Molecular Biology-SBBq (2005-2007). Prof. Oliva has lead several projects in collaboration with Brazilian pharmaceutical industries, including programs of biodiversity screening for new natural products drug candidates. Amongst other prizes, he is Member of the Brazilian Academy of Sciences, Member of the National Order of Scientific Merit of Brazil, International Scholar of the Howard Hughes Medical Institute (1997-2001), Member of TWAS (The World Academy of Sciences for the advancement of science in developing countries) and Fellow do Birkbeck College - University of London. He was Director (2010) and President (2011-2015) of the Brazilian National Council for Scientific and Technological Development (CNPq); founder and member of the Governing Board of the Global Research Council (GRC). (Source: Lattes Curriculum)
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We propose establishing a frontier facility, unprecedented in Brazil, focused on selecting and characterizing biological samples for high-resolution structural studies by cryogenic electron microscopy (cryo-EM), revolutionizing structural biology in the last decade. The current implementations of cryo-EM are single particle analysis (SPA), tomography (cryo-ET), and microcrystal diffractio…
The arboviruses that cause Zika, Chikungunya and Yellow fever have been a major public health challenge in Brazil due to climatic conditions conducive to the dissemination of their vectors, the mosquitoes of the Aedes and Haemagogus gender. Despite all the efforts of the academic community, there are still no vaccines or therapeutic agents available for ZIKV and CHIKV, in addition to the …
The Center for Research and Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborativeresearch projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of RibeiraoPreto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), theInst…
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The rapid spread of the COVID-19 global pandemic with exponential growth in cases in Brazil and worldwide, there is great concern about the lethality of the disease and the saturation of hospital beds to treat severe cases. Although the search for an effective vaccine is urgent, any development should require one to two years before it is approved, so there is no expectation that they can…
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Tumor cells exhibit increased glycolytic and glutaminolytic pathways, consuming glucose and glutamine at accelerated rates. The intensification of the glycolytic pathway, known as the Warburg effect, and the glutaminolytic pathway provide various intermediates for different synthetic routes and are hallmarks of malignant transformation. Glutamine, besides providing biosynthetic intermedia…
The arboviruses that cause Zika, Chikungunya and Yellow fever have been a major public health challenge in Brazil due to climatic conditions conducive to the dissemination of their vectors, the mosquitoes of the Aedes and Haemagogus gender. Despite all the efforts of the academic community, there are still no vaccines or therapeutic agents available for ZIKV and CHIKV, in addition to the …
In May 2022, the World Health Organization (WHO) was informed of a confirmed case of monkeypox caused by the Monkeypox virus (MPXV) in the United Kingdom, after which there was a rapid spread of the disease in other countries. To date, there are 86,500 confirmed cases around the world, with 10,878 cases in Brazil alone. Viral transmission usually occurs between people or wild animals, eit…
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Malaria is a parasitic disease caused by Plasmodium species (P. falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi). The disease is widespread in tropical and subtropical regions of the world and represents a global public health problem because of high mortality rates (Figure 1A). In 2020, 241 million cases of malaria with estimated 600,000 deaths were reported by World Health O…
The emergence of a new coronavirus in 2019 generated a pandemic that has lasted until now, so the search for candidates for new antiviral drugs against SARS-CoV-2 has become a priority. The nonstructural protein Nsp13, encoded in the viral genome, is an enzyme with helicase activity dependent on ATP hydrolysis, being essential for viral replication and, therefore, an attractive target wit…
Emerging and reemerging viruses will always constitute a threat and a challenge to global public health. The emergence of a new type of coronavirus (SARS-CoV-2), in December 2019, generated an epidemic that has lasted until now and has already resulted in more than 174,418,411 cases worldwide, with 17,130,234 of them in the Brazilian territory. Statistics still show about 3,757,791 deaths…
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Human cytomegalovirus (HCMV) is a beta-herpesvirus belonging to the Herpesviridae family and Cytomegalovirus genus. The virus is widely spread among the world population establishing a latent infection, and it represents one of the most frequent causes of death among immunocompromised patients and one of the main causes of congenital birth problems. The viral genome is composed by a linea…
Yellow fever virus (YFV) is an acute viral hemorrhagic disease transmitted by infected mosquitoes. The YFV is endemic in tropical areas of Africa and Central and South America. Large epidemics of yellow fever occur when infected people introduce the virus into heavily populated areas with high mosquito density and where most people have little or no immunity, due to lack of vaccination. …
Chagas disease and leishmaniasis are infectious diseases caused by protozoan parasites of the genus Trypanosoma and Leishmania, respectively. Chagas disease is endemic in Latin America, affecting approximately 8 million people. Nearly 10,000 deaths occur each year as result of the clinical consequences of the disease. Leishmaniasis occurs in 98 countries and approximately 1.3 million new …
(Only some records are available in English at this moment)
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