- Research Grants
bachelor's at Medicine from Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo (1986) and doctorate at Genetics from Universidade de São Paulo (1995). She has experience in Medicine, acting on the following subjects: Clinical Genetics, Epigenetics, Disorders of Sex Development, Genomic Imprinting, X-inactivation, Y chromosome. (Source: Lattes Curriculum)
Birds present the ZZ/ZW sex chromosomal system (male and female, respectively). However, the mechanisms of sex determination are still unknown. It has been speculated that Z- and W-specific genes and the male hypermethylated (MHM) region on the Z chromosome are involved in the sex determination of birds. There are evidences that epigenetic mechanisms might be associated with the sex det...
Sexual differential development in the embryo prior to differentiation of the gonad has been documented. The potentially unbalanced expression at preimplantation developmental stages of chromosome X or Y-linked genes might be responsible by the faster development of male than female embryos. Expression of the SRY (Sex-determining Region on Y chromosome) gene, implicated in sex determina...
Genomic imprinting, epigenetic process in which genes are expressed based on their parental origin, is involved in placental development. Many important genes for fetal and placental development are mapped on 11p15.5 region. Two imprinting control region (ICR1 and 2), including the KvDMR1 and H19DMR, regulated most of these genes. The main objectives of our project are to verify the inf...
Birds present the ZZ/ZW sex chromosomal system (male and female, respectively). Some authors have proposed the function of Z- and W-specific genes in bird sex determination. In addition, epigenetic mechanisms might be associated with these processes. The male hypermethylated (MHM) region on the Z chromosome is transcribed as a ncRNA similar to mammals Xist RNA. Nevertheless, there is no...
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
LEITE, Sarah Blima Paulino. Influência da idade gestacional no perfil epigenético placentário. 2012. Dissertação (Mestrado) - Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto.
MACHADO, Filipe Brum. Dissomia uniparental e mosaicismo somático como mecanismos de alterações epigenéticas do imprinting genômico. 2012. Tese (Doutorado) – Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto.