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José Andrés Yunes

CV Lattes GoogleMyCitations ORCID


Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB)  (Institutional affiliation for the last research proposal)
Birthplace: Argentina

Dr Yunes received his PhD in genetics by the State University of Campinas, in 1997, Seven month later he was recruited by the Boldrini Children's Hospital to start a Molecular Biology Laboratory. From 2001 to 2003 he completed his postdoctoral training at the Dana-Farber Cancer Institute, Harvard Medical School. Currently, Dr Yunes is head of the molecular biology laboratory, at Boldrini, and holds secondary appointments in Genetics at the State University of Campinas. His research work is mainly focused on elucidating the genetic and molecular mechanisms of leukemia progression and resistance to therapy. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications19
Citations488
Cit./Article25.7
Data from Web of Science

ERIC F. S. DOS SANTOS; NATHÁLIA M. CURY; TAINARA A. DO NASCIMENTO; CRISTIANO RAMINELLI; GLEISON A. CASAGRANDE; CLAUDIO M. P. PEREIRA; EUCLÉSIO SIMIONATTO; JOSÉ A. YUNES; LUCAS PIZZUTI. Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines. Journal of the Brazilian Chemical Society, v. 28, n. 2, p. 217-224, . (12/12802-1)

CURY, NATHALIA MORENO; CAPITAO, REBECA MONIQUE; BORGES DE ALMEIDA, RENAN DO CANTO; ARTICO, LEONARDO LUIS; CORREA, JULIANA RONCHI; SIMAO DOS SANTOS, ERIC FRANCISCO; YUNES, JOSE ANDRES; DUARTE CORREIA, CARLOS ROQUE. Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 181, . Web of Science Citations: 0. (13/07600-3, 17/02400-7, 14/25770-6, 17/03239-5, 17/14737-6, 14/08247-8)

SILVA, ANA; LARANJEIRA, ANGELO B. A.; MARTINS, LEILA R.; CARDOSO, BRUNO A.; DEMENGEOT, JOCELYNE; ANDRES YUNES, J.; SEDDON, BENEDICT; BARATA, JOAO T.. IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias. Cancer Research, v. 71, n. 14, p. 4780-4789, . Web of Science Citations: 57. (08/10034-1)

LARANJEIRA, A. B. A.; DE VASCONCELLOS, J. F.; SODEK, L.; SPAGO, M. C.; FORNAZIM, M. C.; TONE, L. G.; BRANDALISE, S. R.; NOWILL, A. E.; YUNES, J. A.. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase. LEUKEMIA, v. 26, n. 5, p. 1001-1011, . Web of Science Citations: 14. (08/10034-1, 08/02106-2)

FERNANDES, MONICA T.; GHEZZO, MARINELLA N.; SILVEIRA, ANDRE B.; KALATHUR, RAVI K.; POVOA, VANDA; RIBEIRO, ANA R.; BRANDALISE, SILVIA R.; DEJARDIN, EMMANUEL; ALVES, NUNO L.; GHYSDAEL, JACQUES; et al. Lymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype. British Journal of Haematology, v. 171, n. 5, p. 736-751, . Web of Science Citations: 10. (08/10034-1, 12/12802-1)

SILVEIRA, ANDRE BORTOLINI; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; LIBANIO RODRIGUES, GISELE OLINTO; LEAL, PAULO CESAR; CARDOSO, BRUNO ANTONIO; BARATA, JOAO TABORDA; YUNES, ROSENDO AUGUSTO; TONIN ZANCHIN, NILSON IVO; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia. ONCOTARGET, v. 6, n. 15, p. 13105-13118, . Web of Science Citations: 14. (08/10034-1)

CAMPOS, LIVIA WEIJENBORG; ZENATTI, PRISCILA PINI; PISSINATO, LEONARDO GRANATO; RODRIGUES, GISELE O. LIBANIO; ARTICO, LEONARDO LUIS; GUIMARAES, THAIS RAFAEL; ARCHANGELO, LETICIA FROHLICH; MARTINEZ, LEANDRO; BROOKS, ANDREW J.; YUNES, JOSE ANDRES. Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity. Blood, v. 133, n. 11, p. 1259-1263, . Web of Science Citations: 2. (10/16947-9, 12/12802-1, 14/20015-5, 13/08293-7)

TAMURA, R. E.; DE VASCONCELLOS, J. F.; SARKAR, D.; LIBERMANN, T. A.; FISHER, P. B.; ZERBINI, L. F.. GADD45 Proteins: Central Players in Tumorigenesis. CURRENT MOLECULAR MEDICINE, v. 12, n. 5, p. 634-651, . Web of Science Citations: 107.

JOTTA‚ PY; GANAZZA‚ MA; SILVA‚ A.; VIANA‚ MB; DA SILVA‚ MJ; ZAMBALDI‚ LJG; BARATA‚ JT; BRANDALISE‚ SR; YUNES‚ JA. Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. LEUKEMIA, v. 24, n. 1, p. 239-242, . (08/10034-1)

DE VASCONCELLOS, JAIRA FERREIRA; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; TONIN ZANCHIN, NILSON IVO; OTUBO, ROSEMARY; VAZ, THAIS HALINE; CARDOSO, ANGELO ALMEIDA; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. Increased CCL2 and IL-8 in the Bone Marrow Microenvironment in Acute Lymphoblastic Leukemia. PEDIATRIC BLOOD & CANCER, v. 56, n. 4, p. 568-577, . Web of Science Citations: 24. (08/02106-2, 05/02390-4)

MILANI, MATEUS; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; DE VASCONCELLOS, JAIRA FERREIRA; BRANDALISE, SILVIA REGINA; NOWILL, ALEXANDRE EDUARDO; YUNES, JOSE ANDRES. Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice. PLoS One, v. 10, n. 6, . Web of Science Citations: 3. (08/10034-1, 12/12802-1)

MENDES, RUI D.; SARMENTO, LEONOR M.; CANTE-BARRETT, KIRSTEN; ZUURBIER, LINDA; BUIJS-GLADDINES, JESSICA G. C. A. M.; POVOA, VANDA; SMITS, WILLEM K.; ABECASIS, MIGUEL; YUNES, J. ANDRES; SONNEVELD, EDWIN; et al. PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events. Blood, v. 124, n. 4, p. 567-578, . Web of Science Citations: 38. (08/10034-1)

DE VASCONCELLOS, JAIRA FERREIRA; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; LEAL, PAULO C.; BHASIN, MANOJ K.; ZENATTI, PRISCILA PINI; NUNES, RICARDO J.; YUNES, ROSENDO A.; NOWILL, ALEXANDRE E.; LIBERMANN, TOWIA A.; ZERBINI, LUIZ FERNANDO; et al. SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1. PLoS One, v. 10, n. 8, . Web of Science Citations: 5. (05/02390-4, 08/02106-2)

DOS SANTOS, ERIC F. S.; CURY, NATHALIA M.; DO NASCIMENTO, TAINARA A.; RAMINELLI, CRISTIANO; CASAGRANDE, GLEISON A.; PEREIRA, CLAUDIO M. P.; SIMIONATTO, EUCLESIO; YUNES, JOSE A.; PIZZUTI, LUCAS. Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines. Journal of the Brazilian Chemical Society, v. 28, n. 2, p. 217+, . Web of Science Citations: 5. (12/12802-1)

DA SILVA, RODRIGO FERNANDES; CARDOZO, DANIELA MAIRA; LIBANIO RODRIGUES, GISELE OLINTO; DE SOUZA-ARAUJO, CAROLINE NATANIA; MIGITA, NATACHA AZUSSA; LUCCI DE ANGELO ANDRADE, LILIANA APARECIDA; DERCHAIN, SOPHIE; YUNES, JOSE ANDRES; GUIMARAES, FERNANDO. CAISMOV24, a new human low-grade serous ovarian carcinoma cell line. BMC CANCER, v. 17, . Web of Science Citations: 0. (11/14520-0, 16/07822-4, 14/07401-3, 12/12802-1)

DE VASCONCELLOS, JAIRA FERREIRA; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; TONIN ZANCHIN, NILSON IVO; OTUBO, ROSEMARY; VAZ, THAIS HALINE; CARDOSO, ANGELO ALMEIDA; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. Increased CCL2 and IL-8 in the Bone Marrow Microenvironment in Acute Lymphoblastic Leukemia. PEDIATRIC BLOOD & CANCER, v. 56, n. 4, p. 568-577, . Web of Science Citations: 24. (08/02106-2, 05/02390-4)

MANSUR, MARCELA BRAGA; HASSAN, ROCIO; BARBOSA, THAYANA C.; SPLENDORE, ALESSANDRA; JOTTA, PATRICIA Y.; YUNES, JOSE ANDRES; WIEMELS, JOSEPH L.; POMBO-DE-OLIVEIRA, MARIA S.. Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia. BMC CANCER, v. 12, . Web of Science Citations: 23. (08/10034-1)

CAMPOS, LIVIA WEIJENBORG; PISSINATO, LEONARDO GRANATO; YUNES, JOSE ANDRES. Deleterious and Oncogenic Mutations in the IL7RA. CANCERS, v. 11, n. 12, . Web of Science Citations: 0. (12/12802-1, 14/20015-5)

SEIDINGER, ANA L.; CAMINHA, ISABEL P.; MASTELLARO, MARIA J.; GABETTA, CARMEN S.; NOWILL, ALEXANDRE E.; PINHEIRO, VITORIA R. P.; YUNES, JOSE A.. TP53p.Arg337His geographic distribution correlates with adrenocortical tumor occurrence. MOLECULAR GENETICS & GENOMIC MEDICINE, . Web of Science Citations: 0. (11/05657-2)

CURY, NATHALIA MORENO; MUEHLETHALER, TOBIAS; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; CANEVAROLO, RAFAEL RENATINO; ZENATTI, PRISCILA PINI; LUCENA-AGELL, DANIEL; BARASOAIN, ISABEL; SONG, CHUNHUA; SUN, DONGXIAO; DOVAT, SINISA; et al. Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. ISCIENCE, v. 21, p. 95+, . Web of Science Citations: 0. (14/08247-8, 17/14737-6)

GIUSTI, GUILHERME NAVARRO NILO; JOTTA, PATRICIA YOSHIOKA; LOPES, CAROLINE DE OLIVEIRA; GANAZZA, MONICA APARECIDA; AZEVEDO, AMILCAR CARDOSO; BRANDALISE, SILVIA REGINA; MEIDANIS, JOAO; YUNES, JOSE ANDRES. Test trial of spike-in immunoglobulin heavy-chain (IGH) controls for next generation sequencing quantification of minimal residual disease in acute lymphoblastic leukaemia. British Journal of Haematology, v. 189, n. 4, . Web of Science Citations: 0. (18/00031-7, 17/03942-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MILANI, Mateus. Desenvolvimento de modelo animal de leucemia linfóide aguda pediátrica : teste ELISA para monitorar a progressão da leucemia. Dissertação (Mestrado) -  Instituto de Biologia.  Universidade Estadual de Campinas.  (11/01725-3

CAMINHA, Isabel Pereira. Prevalência da mutação germinativa TP53 p.R337H na região metropolitana de Campinas e cidades circunvizinhas. Tese (Doutorado) -  Instituto de Biologia.  Universidade Estadual de Campinas.  (11/05657-2

JOTTA, Patricia Yoshioka. Mutações de PTEN nas leucemias linfóides agudas T. Tese (Doutorado) -  Instituto de Biologia.  Universidade Estadual de Campinas (UNICAMP).  (07/00926-0

VASCONCELLOS, Jaíra Ferreira de. Identificação e estudo de genes diferencialmente expressos pelo estroma da medula ossea leucemica. Tese (Doutorado) -  Faculdade de Ciências Médicas.  Universidade Estadual de Campinas (UNICAMP).  (06/01158-3

CANEVAROLO, Rafael Renatino. Metabolômica da resistência ao metotrexato na leucemia linfóide aguda. Dissertação (Mestrado) -  Faculdade de Ciências Médicas.  Universidade Estadual de Campinas (UNICAMP).  (09/04167-1

LARANJEIRA, Angelo Brunelli Albertoni. Participação do IGFBP7 na interação leucemia-estroma e na resistência a quimioterapia. Tese (Doutorado) -  Instituto de Biologia.  Universidade Estadual de Campinas (UNICAMP).  (08/02106-2

CANEVAROLO, Rafael Renatino. Resistência ao metotrexato está diretamente associada à concentração de glutationa em linhagens de leucemia linfoide aguda. Tese (Doutorado) -  Universidade Estadual de Campinas, Faculdade de Ciências Médicas.  (12/11952-0

RODRIGUES, Gisele Olinto Libanio. Identificação de mutações funcionalmente associadas ao mutante IL7R'alfa' na LLA-T : Identification of mutations functionally associated with IL7R'alpha' mutant in T-ALL. Tese (Doutorado) -  Universidade Estadual de Campinas, Instituto de Biologia.  (12/10284-3

Patent applications

SEQUÊNCIAS DE DNA, KIT E USO PARA DETECÇÃO DA MUTAÇÃO TP53 R337H BR1020120311828 - Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB); Universidade Estadual de Campinas (UNICAMP). José Andres Yunes; Isabel Pereira Caminha; Ana Luiza Ongaro Seidinger Conte; Carmen Sílvia Gabetta - December 2012, 07

ACIL-HIDRAZONAS COMO PROTÓTIPO DE NOVOS FÁRMACOS PARA LEUCEMIA LINFÓIDE AGUDA (LLA) PI1107312-8 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Taisa Regina Stumpf; Paulo César Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; Rosendo A. Yunes; Ângelo Bruneli Albertoni Laranjeira - November 2011, 25

ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF CA2869807 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Taisa Regina Stumpf; Paulo César Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; Rosendo A. Yunes; Ângelo Bruneli Albertoni Laranjeira - November 2012, 26

ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF CN201280063518 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26

ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF EP20120851308 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26

ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF JP2014542646 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26

ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF PCT/BR2012/000480 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26

PROCESSO DE CONVERSÃO EM PLANTAS DE PRÓ-PEPTÍDEOS EM PEPTÍDEOS BIOATIVOS, ATRAVÉS DE ATIVIDADE PROTEOLÍTICA CONTROLADA, UTILIZANDO VETOR E CASSETE PARA EXPRESSÃO DE UMA ENZIMA CAPAZ DE REALIZAR ESTA CONVERSÃO, PLANTAS TRANSGÊNICAS E HÍBRIDOS DERIVADOS, CONTENDO CASSETES DE EXPRESSÃO E USO E COMPOSIÇÃO FARMACÊUTICA DAS PROTEÍNAS RECOMBINANTES ASSIM PRODUZIDAS PI0405361-3 - Universidade Estadual de Campinas (UNICAMP). Mário Del Giúdice Paniago; Adilson Leite - November 2004, 26

ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF RU2014125519 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26

ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF US14/360,279 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26

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