Graduated in Medicine from the Federal University of Uberlândia (1989), Medical Residency in Pediatrics (1992) with an area of expertise in Pediatric Oncology and Hematology (1993), Master's Degree in Pediatrics-FMRP from the University of São Paulo (1996) and PhD in Pediatrics FMRP-USP from the University of São Paulo (2000), postdoctoral fellow from Fondazione Tettamanti of the University of Milano-Biccoca, Italy (2003). He is currently Full Professor (MS-6) at the Department of Child Care and Pediatrics at the Faculty of Medicine of Ribeirão Preto at the University of São Paulo, coordinator of the Pediatric Oncology and Hematology Division at the Hospital das Clínicas at FMRP-USP and President of the Research Commission and Innovation at FMRP-USP. He has experience in the area of Medicine, with an emphasis on Oncology and Pediatric Hematology, working mainly on the following topics: pediatric oncology, acute leukemia, pediatric solid tumors and pediatric hematology. (Source: Lattes Curriculum)
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Acute lymphoblastic leukemias (ALL) and central nervous system (CNS) tumors represent the largest group of childhood tumors. Despite therapeutic advances, the prognosis of CNS tumors is still poor, and they continue to be the main cause of cancer mortality in children. In ALL, despite a better prognosis, 10-15% of children relapse and in 40% of cases present CNS infiltration. The chemores…
Currently, even with intensive multimodal treatment, 20% of children and adolescents with cancer will still die due to disease and over 40% of survivors develop sequelae that affect the adult quality of life. Therefore, more effective and safer treatment options for children with cancer are still needed to increase cure rates, decrease toxicity and to minimize the risk of long term effect…
Glioblastoma is the most common and aggressive of primary brain tumors. Despite technological advances in the surgical procedure, followed by radiotherapy and chemotherapy, the average survival of patients is 12 to 15 months. This type of tumor has high cellular heterogeneity, with complex genetic alterations that reflect high genomic instability and have persistent malignant progression,…
Differences in the microRNA (miRs) signature and functional studies of genes associated to cancer could help in diagnosis, prognosis and suggest new insights in important pathways that could be used as potential therapeutic targets in human malignancies. The aim of this project is to identify miR signatures in different pediatric tumors (acute lymphoblastic leukemia, central nervous syste…
(Only some records are available in English at this moment)
Adrenocortical tumor (ACT) is a rare neoplasm with a poor prognosis in advanced cases. These tumors exhibit high heterogeneity, and the anatomopathological parameters used, especially in pediatric cases, are considered imprecise. So far, it has not been possible to establish a well-defined prognostic correlation, which results in difficulties in determining disease progression and guiding…
Ependymomas (EPNs) are rare neoplasms that develop from the ependymal cells that line the ventricular system of the brain and the spinal canal. It is the third most common tumor of the central nervous system (CNS) in children and can develop in the supratentorial region (ST), posterior fossa (FP) and spinal cord (SP). Intracranial ependymomas are the most frequent in childhood and are cur…
Medulloblastoma (MB) is a solid malignant tumour of the central nervous system (CNS) located in the cerebellum, which most affects and kills children. The prognosis and survival rate of patients with MB vary according to molecular subgroups: SHH (Sonic Hedgehog), which represents about 30% of cases, separated into tumours with mutated or wild-type TP53 gene; WNT (Wingless), which correspo…
Medulloblastoma (MB) is the most common pediatric malignant tumor of the central nervous system (CNS), representing approximately 20% of CNS tumors in children and adolescents. For these patients, the five-year overall survival (OS) is 40 to 90%, with variations between the molecular subgroups of MB (SHH, WNT, Group 3 and 4), among which Group 3 and SHH with TP53-mutated represent the mos…
Medulloblastomas (MBs) of Groups 3 and 4 are malignant tumors of embryonic origin. Unfortunately, to date, these molecular groups are scarce in the characterization of new biomarkers for therapeutic purposes, which reflects a worse prognosis of the disease and an increase in relapses. In light of the above, we draw attention to the USP2 gene, a putative effector of cross-talks between the…
Pediatric adrenocortical tumor (ACT) is a rare neoplasm with poor prognosis in advanced cases. These tumors have a high heterogeneity, and the anatomopathological parameters used are considered inaccurate and so far, it is not possible to establish a well-defined prognostic correlation, which reflects difficulties in determining the progression of the disease and target-treatment. Complet…
(Only some records are available in English at this moment)
Medulloblastoma (MB) represents ~20% of all pediatric central nervous system malignancies. Group 3 tumors are considered the most aggressive forms of MB and are associated with the worst prognosis. Group 3 tumors also display increased metabolic activity, which is induced by malignant transformation to promote tumor cells' survival. Under conditions of cellular stress in the tumor microen…
The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocorticoids, and adrenal androgens, respectively. Starting shortly after birth, a rapid, dramatic remodeling of adrenal cortex structure takes place, with massive shrinkage of the gland due to apoptosis o…
The treatment of glioblastoma (GBM) remains a major challenge for clinicians since these highly aggressive brain tumors are highly resistant to radio- and chemotherapy, and recurrence is practically inevitable. The poor prognosis of GBM patients is in part due to the presence of a heterogeneous population of glioblastoma stem cells (GSCs) within the tumor, characterized by invasive behavi…
MicroRNAs (miRNAs) are small noncoding single-stranded molecules that function as regulators of mRNAs through translational repression in a manner sequence-specific. Therefore the search for sequence-specific targets of microRNAs is a major area of research, especially in cancer. It is known that some miRNAs (oncomirs) targets oncogenes and its loss enhances the expression of the related …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 14 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 30 / 27 | All research grants and scholarships |
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CV Lattes
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