CV Lattes
Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Farmacia e Bioquimica from Universidade de São Paulo (1978), master's at Pharmacy from Universidade de São Paulo (1981) and ph.d. at Biochemistry from Universidade de São Paulo (1988). Has experience in Biochemistry, focusing on Metabolism and Bioenergetics, acting on the following subjects: atherosclerosis, cardiovascular risk biomarkers and modified lipoproteins. (Source: Lattes Curriculum)
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In order to identify those microRNAs involved in the modulation of angiogenesis-related genes that was observed after treatment with polyphenols from propolis, different cell types participating in the formation of atherosclerotic plaque will be used. In macrophages, endothelial cells and smooth muscle cells, the expression of pro-angiogenic factors and microRNAs modulated by treatment wi…
Propolis has attracted attention in recent years due to its beneficial effects, whichmake it a potential preventive and therapeutic agent as well as a useful additivein foods and cosmetics. The aim of this review is to discuss the growing evidencethat propolis may, via a diverse array of biological actions, assist in theprevention of some inflammation-mediated pathologies including cardio…
(Only some records are available in English at this moment)
Introduction: Among the various modified forms of low density lipoprotein (LDL), electronegative LDL [LDL (-)] is an endogenously modified subfraction that contributes to the atherosclerotic process, modulating the inflammatory response. Considering that the protein portion of LDL (ApoB-100) is targeted by autoantibodies, peptides derived from this antigen have been investigated for the d…
Thiazolidinediones (TZDs) comprise a class of hypoglycemic drugs which reduce insulin resistance in peripheral tissues. Evidences indicate that TZDs hypoglycemic effects is peroxisome proliferator-activated receptors (PPARs) mediated, on its gamma, alpha and/or beta/delta isoforms. Initially, three TZDs were approved to clinical use: troglitazone, rosiglitazone and pioglitazone. Recently,…
Atherosclerosis is a chronic inflammatory disease induced by modification of low density lipoproteins (LDL). LDL particles are spherical with a core of nonpolar cholesterol esters and triglycerides surrounded by phospholipids and unesterified cholesterol and a molecule of apolipoprotein B - 100. The modification of LDL occurs by various processes leading to profiles modifications since el…
(Only some records are available in English at this moment)
The tryptophan metabolism through the kynurenine pathway is pivotal to the polarization of regulatory T cell. Not only tryptophan but also other metabolic pathways such as glycolysis have been shown to modulate immune cell responses. It is our aim to investigate whether tryptophan modulation and the energy metabolism on immune cells can act as "natural adjuvants" and improve anti-atherosc…
The thiazolidinediones (TZDs) class comprises drugs with hypoglycemic effects by activation of alpha/gamma peroxisome proliferator-activated receptor isoforms (PPAR±, PPAR³ and PPAR ²/´). Besides insulin sensitizer effect, some clinical studies have linked TZDs treatment to anti-inflammatory potential probably due to PPAR³ agonism. Although these beneficial effects, prolonged use of TZDs …
The thiazolidinediones (TZDs) class comprises drugs with hypoglycemic effects by activation of alpha/gamma peroxisome proliferator-activated receptor isoforms (PPAR±, PPAR³ and PPAR ²/´). Besides insulin sensitizer effect, some clinical studies have linked TZDs treatment to anti-inflammatory potential probably due to PPAR³ agonism. Although these beneficial effects, prolonged use of TZDs …
(Only some records are available in English at this moment)
| 21 / 11 | Completed research grants |
| 43 / 9 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 71 / 27 | All research grants and scholarships |
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