Fernando Morgan de Aguiar Correa

• Abstract

  Hypertension is a major health problem. The two kidney, one clip model of hypertension elicits significant activation of the renin angiotensin system and promotes vascular remodeling associated with oxidative stress and activation of matrix metalloproteinases (MMPs). These enzymes are regulated by oxidative stress. Statins (cholesterol lowering drugs) and sildenafil (a phosphodiesterase 5…

  Effects of drugs that activate the nitric oxide-GMPc pathway on the vascular alterations associated with renovascular hypertension, AP.R

• Abstract

  Several pieces of evidence, including those originated from our group in Ribeirão Preto in the last 30 years, indicate that typical (glutamate, GABA and serotonin) and atypical (nitric oxide, NO) neurotransmitters are involved in anxiety, mood, psychotic and related motor disorders. More recently the endocannabinoid system was also related to these disorders. The main goal of the present …

  Typical and atypical neurotransmitters in neuropsychiatric disorders, AP.TEM
• The lateral septal area is involved in pressor response to noradrenaline injection within the cingulate cortex in unanesthetized rats., AR.EXT

(Only some records are available in English at this moment)

• Abstract

  Stress is an organism's condition in response to exposure to adverse environmental situations, involving essential adaptive responses for survival. The activation of the hypothalamus adrenal-axis, autonomic nervous system and brain structures (eg.: brainstem and amygdala), have an important role in stress, and consequently also in the related pathophysiological process. Oxytocin can be a …

  Cardiovascular, behavioral, neuroendocrine and morphofunctional effects evoked by acute restraint in rats: involvement of the oxytocinergic pathway, BP.DR

• Abstract

  The supraoptic nucleus of the hypothalamus (SON) has been implicated in the central cardiovascular control. Furthermore, The SON has neural connections with several limbic structures involved with both autonomic and behavioral controls during defensive situations. It was shown that exposure of animals to acute restraint stress (ER) causes neuronal activation of the SON, suggesting that th…

  Function of the supraoptic nucleus of the hypothalamus in the cardiovascular and neuroendocrine responses observed in rats submitted to acute restraint stress in rats, BP.PD

• Abstract

  The control of metabolism and eating behavior is highly complex and is regulated by neurotransmitters and neuromodulators present in the central nervous system (CNS).The hypothalamus is the main structure involved in the regulation of food intake, however, this structure is modulated by other areas of the CNS, especially, limbic strutures that are involved in the control of emotions and b…

  Study of the involvement of endocannabinoid system into the prefrontal medial córtex on food intake of rats., BP.PD

(Only some records are available in English at this moment)

• Abstract

  Stress is a situation common in life and demands physiological and behavioral changes to reestablish homeostatic equilibrium. Stressor exposure may cause stressor-dependent responses including behavioral and neuroendocrine responses as activation of the HPA axis and the oxytocin (OXT) system. OXT secretion into the blood has been observed in response to acute psychological and social stre…

  Effects of acute versus chronic social and non-social stress on social fear conditioning and the regulatory role of neuropeptides in male mice, BE.EP.DR

• Abstract

  Cardiovascular diseases such as hypertension are associated with increased activation of matrix metalloproteinases (MMPs). MMPs are calcium-dependent endopeptidases, expressed in various cells and tissues including vascular smooth muscle cells, endothelial cells, fibroblasts and inflammatory cells. These enzymes can be regulated by various processes, and an increase in activation of these…

  Effects of drugs activating the NO-cGMP pathway on the production of MMPs in cell culture, BE.EP.DR

• Abstract

  The paraventricular nucleus of the hypothalamus (PVN) is involved in control of autonomic, neuroendocrine and behavioral responses. In previous study, we observed that PVN pretreatment with synaptic inhibitor reduced the pressor response, the fall in tail skin temperature and increase in plasma corticosterone induced by restraint stress (RS). Despite evidence of the involvement of the PVN…

  Study of the involvement of the nitric oxide-guanylate cyclase mechanism in the paraventricular nucleus of hypothalamus on local neuronal activation and hypothalamic-pituitary-adrenal stimulation induced by restraint stress in rats, BE.EP.PD

(Only some records are available in English at this moment)