Maria Tereza Nunes in research grants and scholarships supported by FAPESP.
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Thyroid hormones (TH) play essential roles in complex biological processes by regulating the expression of genes/proteins involved in metabolism, growth and development; these actions are known as genomic. However, some TH actions, known as nongenomic, occur in the presence of inhibitors of gene transcription, are rapidly triggered, and are elicited by T2 and rT3, classically considered a…
Iodine is essential for the thyroid hormones (TH) synthesis. Its uptake occurs via the Na+/I- Symporter (NIS), and its efflux to the follicular lumen, where it is oxidized and organified, occurs via Pendrina, a protein expressed along the apical plasma membrane of the thyrocytes. However, it is known that the chronic ingestion of high doses of iodide can be harmful for thyroid function, b…
(Only some records are available in English at this moment)
Diabetes Mellitus (DM) is the main metabolic disease nowadays, being characterized by hyperglycemia resulting either from the lack of insulin or from peripheral resistance to its action. In addition to a chronic subclinical inflammation that is well studied in the literature and responsible for several deleterious effects, DM also courses with thyroid dysfunction, being the hypothyroidism…
Diabetes mellitus (DM) is an endocrinopathy that occurs due to impairments in the secretion/action of insulin, which is mainly characterised by hyperglycaemia. In the central nervous system (CNS), insulin deficiency impairs several processes, like the cognitive ones, which are related to the hippocampal formation (HF). DM is also associated to inflammation and thyroid disfunctions, mainly…
Introduction: Triiodothyronine (T3) exerts important effects on heart and glycidic metabolism. We demonstrated that alloxan-induced diabetes mellitus (DM) rats have hypothyroidism, a condition in which cardiac activity is reduced, and that their treatment with T3 promoted a reduction in blood glucose and insulin resistance, and cardiac hypertrophy without changes in blood pressure, systol…
Nowadays, Diabetes Mellitus (DM) is considered the most prevalent endocrinopathy worldwide. It has been demonstrated that changes in glucose metabolism and insulin deficiency and/or resistance in central nervous system (CNS) are related to neurodegenerative diseases. It is known that the induction of DM1 leads to hypothyroidism, and that thyroid hormones (TH), besides being essential for …
Diabetes mellitus (DM) is the most prevalent endocrinopathy around the world. Recently, many studies have indicated a positive correlation between DM and thyroid dysfunctions. Indeed, studies in our laboratory have detected primary hypothyroidism in rats with alloxan-induced type 1 diabetes. The triiodothyronine (T3) treatment promoted enhancement of insulin sensitivity and reduced glycem…
(Only some records are available in English at this moment)
The anterior pituitary gland occupies a central position in the hypothalamus-pituitary-gland/tissues axes, regulating the synthesis/secretion of hormones related to reproduction, growth and metabolism. The plasma concentration of pituitary hormones fluctuates over 24 h. The generation/maintenance of circadian rhythmicity, central or peripheral, is determined by a set of genes called clock…
Hypothalamus is a well known portion of the central nervous system which modulates hormone concentration in responses to metabolism balance feedback. Alteration in lactacidemia informs neurons located in this region that energy demand has increased, triggering counter regulatory actions. As we are showing in our PhD study, lactate stimulates numerous hypothalamic neurons and they could co…
Both iodine deficiency (ID) and excess (IE) impair thyroid hormones synthesis, causing serious consequences especially during fetal/neonatal periods. Our previous data indicated that pregnant rats exposed to IE induced hypothyroidism in the adult male rats offspring through epigenetic mechanisms. This study aims to investigate the effects of IE exposure on the development and differentiat…
(Only some records are available in English at this moment)
| 18 / 12 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 41 / 17 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 68 / 38 | All research grants and scholarships |
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