graduate at Ciências Biológicas from Universidade de São Paulo (1977), graduate at Odontologia from Universidade de São Paulo (1981), master's at Pharmacology from Universidade de São Paulo (1988) and ph.d. at Reabilitação Oral from Universidade de São Paulo (1994). Has experience in Odontology, focusing on Odontology, acting on the following subjects: cultura de células, osteoblastos, titânio, osteogênese and biocompatibilidade. (Source: Lattes Curriculum)
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Bone exhibits high healing potential but depending on the damage extension additional treatments are needed to assure tissue repair. Therapies based on cells produce meaningful bone formation; however, without inducing the complete bone regeneration. Based on evidences that modifications of cells enhance their capacity to regenerate tissues, the aim of this project is to regenerate bone u…
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
(Only some records are available in English at this moment)
Bone has a high regenerative capacity, but in some cases the extension of the lesion prevents tissue repair. In this context, cell therapy has been the focus of several research groups as an alternative to the current treatments. However, several molecular, cellular and tissue aspects were not addressed by the literature and need to be investigated in order to make cell therapy an effecti…
Tissue engineering is an interdisciplinary science based on the combination of scaffolds, cells and growth factors aiming at repairing lost or damage tissues. Tissue engineering strategies as therapy for the treatment of bone defects resulting from trauma, infections and pathologic processess are of major intereste in oral and maxillofacial and orthopedic fields. Some preliminar results s…
The bone tissue supports and protects the most soft and fragile tissues in the human body, thus requiring resistance without excessive weigh that would overburden the muscles. In order to achieve this goal efficiently, complex mechanisms of bone remodeling and repair are orchestrated by hormones and immune cytokines; such interaction has been ultimately nominated Osteoimmunology. Recently…
(Only some records are available in English at this moment)
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
Extracellular Vesicles (EVs) take part in sophisticated intercellular communication mechanisms relevant to the Regenerative Medicine field based on cellular therapy using Mesenchymal Stem Cells (MSCs) because these cells are able to generate and release EVs to the extracellular milieu. This study will test the hypothesis that EVs combined with MSCs induce the bone regeneration of rat calv…
Bone tissue shows great regeneration capacity when injured by trauma, inflammation or neoplasms. However, in many situations the damage exceeds its regeneration capacity. For these cases, some additional treatments are needed, including pharmacological therapy based on anabolic drugs to bone tissue and cell therapy based on local cell injections. For pharmacological therapy, two clinicall…
(Only some records are available in English at this moment)
Osteoporosis (OP) is a bone metabolic disease which is considered a global health problem. Literature data have shown that patients taking antiresorptive drugs, such as bisphosphonates (BP), have an increased risk of developing atypical femoral fracture (AFF). The pathogenesis of AFF remains unknown, but studies in patients with OP who suffered AFFs have revealed that there is a mutation …
Particular interest in the areas of maxillofacial surgery and orthopedics is the treatment of non-union fractures. Among the myriad of available treatments, cell therapy has emerged as a promising approach but according to our results, not enough to get bone regeneration. Thus, we propose the use of gene therapy to fulfill and improve this still unmet need. For this, we selected genes inv…
Bone tissue engineering uses the combination of cells, biochemical factors and scaffolds to replace bone tissue and recover its biological functions. Among the biomaterials that have been employed as scaffolds, bioactive glasses emerge as a promising alternative, due to their ability to stimulate in vitro osteogenesis. This process may be regulated by post-transcriptional mechanisms invol…
| 4 / 4 | Ongoing research grants |
| 22 / 11 | Completed research grants |
| 38 / 24 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 68 / 42 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID