CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Bacharelado em Química from Universidade de São Paulo (2005) and doctorate at Biochemistry from Universidade de São Paulo (2010). , acting on the following subjects: bacterial motility, pilz, xanthomonas, c-digmp and eal domain. (Source: Lattes Curriculum)
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In this work, we will be working with two bacteria: the plant pathogen Xanthomonas citri (X. citri) and the human pathogen Leptospira interrogans (Lic). X. citri causes citrus canker in citrus crops, causing significant damage to Brazilian agriculture. It is a bacterium that uses an extracellular appendage, the type IV pilus (T4P), to move around (twitching). This filament is assembled th…
The CEPID B3 is a network with research hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) that will collaborate to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interaction…
Our research group, in collaboration with researcher Dr. Edison Durigon of ICB USP, is developing a fast diagnostic tests to detect COVID-19. For this, we have already clone and express 4 fragments of the SARS-CoV-2 surface protein spike and have shown to be immonogenic against the serum of a human patient. For the production of the fast diagnostic test, proteins were produced on a large …
The goals of the project are the study of proteins of the human pathogen Leptospira interrogans. This bacterium is the causative agent of leptospirosis, a re-emerging infectious disease considered a zoonosis worldwide that affects several animals including humans. More than 500,000 cases of severe leptospirosis are reported per year, and in severe cases the patient ends up dying. Due to t…
Bacterial macromolecular protein secretion systems are large (multi-mega Dalton) multiprotein complexes that transport effector proteins through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells. These systems also mediate the horizontal transfer of genetic material (conjugation) between bacterial cells and specialized homologous forms of these …
(Only some records are available in English at this moment)
Bacteria use different horizontal transfer mechanisms to spread genetic information among themselves, the most common one being conjugation, a process mediated by the type IV secretion system (T4SS). T4SS nanomachines are used not only in conjugation, a process in which ssDNA or dsDNA are translocated from a recipient cell to a donor cell, but also during pathogenesis to translocate prote…
The bacterial flagellum is a macromolecular complex essential for the motility and virulence of several bacteria. In spirochetes, such as Leptospira interrogans, the flagellum has a unique structure and location, being periplasmic and presenting a specific component called "P-collar" (FlbD). The FliL protein also plays an important role in generating torque in the flagellar motor, interac…
Staphylococcus aureus is a Gram-positive pathogenic bacterium associated with various human infections, including pneumonia and bacteremia. It is notorious for its antibiotic resistance, complicating the treatment of diseases caused by this bacterium. The project focuses on the structure of proteins in the type IV secretion system (T4SS), an essential machinery for genetic transfer and th…
(Only some records are available in English at this moment)
In an era of increasing antimicrobial resistance and the emergence of multi-resistant bacteria, the transfer of plasmids through conjugation is of significant relevance. This process, long characterized as mediated by a specialized type IV secretion system (T4SS), has been relatively less explored in Gram-positive bacteria. Recently, bioinformatics analyses conducted by our research group…
Bacteria of the genus Leptospira are renowned for causing a disease called Leptospirosis, which poses a substantial public health problem and is grossly neglected. Consequently, due to both the challenges associated with manipulating these bacteria in a laboratory environment and the lack of attention given to them, many fundamental aspects remain inadequately explored. One such aspect pe…
Leptospirosis is a zoonosis caused by bacteria of the genus Leptospira, a gram-negative spirochaete of translational motility. L. interrogans is the main cause of leptospirosis in humans, being characterized by varied virulence mechanisms such as tissue invasion, biofilm formation, adhesion to several types of cell lines, and secretion of enzymatic effectors which establish pathogenesis. …
(Only some records are available in English at this moment)
Bacteria and some eukaryotic organelles have nanomachines formed by large protein complexes that act in the process of secretion, in most of the cases, of macromolecules to the extracellular medium or directly into the host cell. These systems are called secretion systems and until now, were identified seven general classes of secretion systems and the chaperona/Usher system. There is a g…
| 2 / 2 | Ongoing grants |
| 5 / 4 | Completed research grants |
| 10 / 10 | Ongoing scholarships in Brazil |
| 18 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 36 / 33 | All research grants and scholarships |
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