CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Biology from Universidade Federal do Rio de Janeiro (1983), master's at Microbiologia from Universidade de São Paulo (1988) and PhD at Molecula Biology from Rijksuniversiteit Gent (1994). He has experience in Genetics, acting on the following subjects: Aspergillus nidulans and Aspergillus fumigatus. (Source: Lattes Curriculum)
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Our consortium proposes a timely project in the context of the current antifungal resistance. The two PIs are internationally recognized in their respective field and we propose to combine our expertise to advance the state-of-the-art research in fungal cell wall biology and biophysics. Several activities will be highly desirable to achieve a strong partnership between the Brazilian and F…
The human pathogenic fungus Aspergillus fumigatus establishes biofilm dual interactions in the lungs with the pathogenic bacterium Pseudomonas aeruginosa. Screening of 21 A. fumigatus null mutants revealed 7 mutants (two GPCRs, three MAPK receptors, a G-alpha protein, and one histidine kinase receptor) with reduced biofilm formation specifically in the presence of P. aeruginosa. We propos…
Invasive Pulmonary Aspergillosis (IPA), mainly caused by Aspergillus fumigatus, is a major infectious complication with mortality rates as high as 90% depending on the immunological status of the host. Azoles are fungicidal drugs for A. fumigatus and the main antifungal agents recommended for IPA. Echinocandins, such as caspofungin (CSP), represent a second line therapy and target the fun…
Fungi are major contributors to human morbidity and mortality but we still know little about the molecular basis of their pathogenicity. Aspergillus-related diseases, collectively known as aspergillosis, are caused by various species in the Aspergillus genus of filamentous fungi. The saprophytic and ubiquitous airborne species Aspergillus fumigatus (section Fumigati) is responsible for mo…
Aspergillus fumigatus is the most important airborne mold pathogen and allergen worldwide. Estimates suggest that over 3 million people have invasive or chronic infections that lead to an excess of 600,000 deaths every year. Only three classes of drugs are currently recommended for the treatment of aspergillosis with the azole class being recommended for primary therapeutic purposes and a…
(Only some records are available in English at this moment)
The pathogenic opportunistic fungus of the genus Aspergillus ssp is the main cause of more than two million infections worldwide. The colonization of fungal strains in the host depends on the regulation, synthesis and remodeling of proteins that organize themselves to constitute the integrity of the cell wall and thus adapt to cellular oxidative stress and ensure its survival. Invasive pu…
It is increasingly observed that the role of the fungal mitochondria goes far beyond energy metabolism. These organelles have been associated with cell differentiation, regulation of hyphal and biofilm growth, drug resistance and virulence. Despite this, the role of the mitochondria of Aspergillus fumigatus, the main pulmonary fungus worldwide, in drug resistance still needs to be clarifi…
Aspergillus fumigatus is the main causative agent of Invasive Aspergillosis (IA), which is considered a serious disease with a high mortality rate, especially in immunocompromised patients. The first drug for treatment is Voriconazole (VRC), which belongs to the azole class. Patients undergoing treatment for AI with VRC are at great risk of A.fumigatus undergoing genetic alterations, whic…
Invasive fungal diseases represent a serious global health problem. Aspergillosis is an opportunistic infection whose etiological agents are filamentous fungi of the genus Aspergillus. More than 60% of aspergillosis cases are caused by Aspergillus fumigatus, while a few other pathogenic species of the genus are responsible for the remainder of cases. Many of these species are closely rela…
(Only some records are available in English at this moment)
Invasive aspergillosis (IA) due to Aspergillus fumigatus causes extensive morbidity and mortality, especially among immunosuppressed patients. Very few classes of antifungal drugs are available for treating this disease and resistance is developing to first line therapeutics. New agents to treat IA are urgently required. When the fungus invades human lungs, it has to adapt to host environ…
Aspergillus fumigatus is a major human pathogen. Several additional species that are genetically distinct but morphologically identical to A. fumigatus can also cause human infection. These so called "cryptic" species are of increasing worldwide concern due to their clinical occurrence and increased antifungal resistance compared to A. fumigatus. Previous analyses of pathogenicity between…
Aspergillus nidulans predominantly causes infections in patients with a genetic immunodeficiency condition named Chronic Granulomatous Disease (CGD). However, it can also infect other immunocompromised patients. Although A. nidulans causes a severe, often fatal disease, especially in CGD patients, little is known about the fungus-host interaction, and how different strains may induce diff…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 60 / 35 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 80 / 35 | Completed scholarships in Brazil |
| 13 / 12 | Completed scholarships abroad |
| 159 / 88 | All research grants and scholarships |
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