CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at MEDICINA from Universidade de São Paulo (1959) and ph.d. at Medicina from Faculdade de Medicina de Ribeirão Preto - USP (1962). Has experience in Physiology, focusing on Endocrinal Physiology, acting on the following subjects: anp, ocitocina, nitric oxide, oxytocin and atrial natriuretic peptide. (Source: Lattes Curriculum)
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The endocrine and nervous systems interact reciprocally with peripheral organ and tissues in the regulation of several body functions. Homeostatic responses are activated by peripheral signals, such as metabolic factors, glucose, FFA, electrolytes, hormones, cytokines, and myokines that interact with neuronal and non-neuronal circuitries for the maintenance of internal milieu. Besides its…
Aging has systemic consequences that can be classified into four processes: body composition, balance between availability and energy demand, network of signs that control homeostasis and neurodegeneration. The characteristic of the normal aging process is a decline in the physiological reserve in many regulatory systems of the body, including those involved in the maintenance of fluid ba…
(Only some records are available in English at this moment)
The hypothalamus plays a central role in controlling energy, water and electrolyte homeostasis, reproduction, sexual maturation, circadian rhythms, sleep cycle, and stress. The molecular regulation within the hypothalamic nuclei spans multiple pathways, but of particular importance is the gene expression and its transcriptional and translational regulations. Data analysis from the entire …
Ghrelin is an orexigenic hormone produced by the stomach. Our previous studies showed that ghrelin affects neurons in the hypothalamic paraventricular nucleus (PVN) and that ghrelin activates GABAergics neurons in the PVN that, in turn, inhibit anorexigenic neurons, such as the neurons that express corticotropin releasing hormone (CRH). The present study aims to assess the participation o…
The prevalence of Obesity worldwide has increased significantly in the last decades, in the diverse age groups of the development. Obesity is characterized by the presence of excess body adiposity, being an independent risk factor for Coronary Artery Disease and for the development of the Metabolic Syndrome. Nutritional changes that occur during the developmental period of the individual …
(Only some records are available in English at this moment)
A novel reproductive peptide was recently described and named Phoenixin (PHXN). The novel neuropeptide PHXN, discovered in 2013 by Yosten et al., and its receptor, GPR173, were identified in magnocellular neurons of the paraventricular nucleus (PVN) and supraoptic nucleus (SON) suggesting a functional importance of PHXN on the control of the hydromineral homeostasis and a modulation on th…
It has been known that heme oxygenase (HO) inhibition compromises not only the carbon monoxide (CO) production but also biliverdin, one of the most important brain antioxidant, and iron, which its homeostasis is implicated with the gene expression. The increased angiotensin II (ANG II) in dehydrated animals (as previous demonstrated by this and several other studies) activates its recepto…
Obesity is a multisystemic disorder characterized by increased percentage of white adipose tissue, and generally associated to peripheral and central resistance to insulin and leptin. These hormones act on the brain, especially in the paraventricular (PVN) and arcuate (ARH) hypothalamic nuclei, regulating energy metabolism and sympathetic tonus (including arterial pressure changes). Thus,…
| 1 / 1 | Ongoing grants |
| 30 / 17 | Completed research grants |
| 55 / 20 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 90 / 41 | All research grants and scholarships |
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