CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Instituto Nacional de Farmacologia (INFAR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Medical degree from the Federal University of São Paulo (1968) and a PhD in Biological Sciences (Molecular Biology) from the Federal University of São Paulo (1974). Currently is a senior professor at the Federal University of São Paulo. Currently, he participates in teaching and works in research at AC Camargo Cancer Center, focusing on interinstitutional relations and new developments Has experience in the field of Biochemistry, with emphasis on Proteins, acting mainly on the themes: peptides, proteases. Since 2005 work in the Convergence of Life Science with physics, chemistry and engineering . This initiative establishes in Brazil the concept of CONVERGENCE, which is considered today the future of the life and medical sciences (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Fewer animals, more research |
| Menos animales, más investigación |
| News published in Agência FAPESP Newsletter about the researcher |
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INCiTO-INOTE will continue to support the scientific program previously created by the INCiTO, exploring bench-to-bedside-to-bench concepts, in order to face the challenges that are still limiting cancer prevention, diagnosis and treatment. The Institute will explore its large experience in genetics, epigenetics “comics”, bioinformatics and biomarkers to focus in areas where it can be wor…
The general objective of this project is to isolate, to know, to preserve and characterize microorganisms from the composting facility and water (from the lakes) of the São Paulo Zoological. Preliminary data show that traditional methods of isolation and preservation can be used for prospection of cultivable microorganisms from composting; however, it is estimated that most of the microor…
The project covers developments of organic syntheses focused on the peptides, peptideomimetics and amino acids and libraries of peptides aimed at the study of proteases. In view of the diversity of proteolytic enzymes that we will be dealing with and because of the involvement of the same in different physiological or physiopathological processes and the integration with organic chemistry…
(Only some records are available in English at this moment)
Alternatives for the disposing of organic waste generated by our society are always a necessity. Among this alternatives the Fundação Parque Zoológico de São Paulo (FPZSP) uses organic waste generated daily in the park for production of composting, which is subsequently used inside of the ZOO and also its farm (Unidade de Produção Rural -UPR) where it is produced most of the food consume…
There are little explored in Brazil environments that can be described as sources of biodiversity with potential application in biotechnological processes, which in this context fits into the biomass generated in the composting of animal manure and vegetable waste produced at the Zoo of São Paulo (FPZSP) . Microorganisms have a high genetic diversity with unique functions and essential in…
(Only some records are available in English at this moment)
Alternatives for the disposing of organic waste generated by our society are always a necessity. Among this alternatives the Fundação Parque Zoológico de São Paulo (FPZSP) uses organic waste generated daily in the park for production of composting, which is subsequently used inside of the ZOO and also its farm (Unidade de Produção Rural -UPR) where it is produced most of the food consume…
| 1 / 1 | Ongoing research grants |
| 30 / 16 | Completed research grants |
| 31 / 4 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 64 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 114 |
| Cit./Article | 11.4 |
| Data from Web of Science | |
BITENCOURT, ANA LUISA V.; VALLIM, MARCELO A.; MAIA, DANIELA; SPINELLI, RAFAEL; ANGELONI, RENATA; PRINCIPAL, LUCIANA; SOUZA, ELISANGELA; PASCON, RENATA C.. Core sampling test in large-scale compost cells for microorganism isolation. African Journal of Microbiology Research, v. 4, n. 15, p. 1631-1634, AUG 4 2010. Web of Science Citations: 5.
OLIVEIRA, LILIAN C. G.; SILVA, VINICIUS O.; OKAMOTO, DEBORA N.; KONDO, MARCIA Y.; SANTOS, SAARA M. B.; HIRATA, ISAURA Y.; VALLIM, MARCELO A.; PASCON, RENATA C.; GOUVEA, IURI E.; JULIANO, MARIA A.; et al. Internally quenched fluorescent peptide libraries with randomized sequences designed to detect endopeptidases. Analytical Biochemistry, v. 421, n. 1, p. 299-307, FEB 1 2012. Web of Science Citations: 18.
GADELHA, ARY; MACHADO, MAURICIO F. M.; YONAMINE, CAMILA M.; SATO, JOAO R.; JULIANO, MARIA A.; OLIVEIRA, VITOR; BRESSAN, RODRIGO A.; HAYASHI, MIRIAN A. F.. Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia - A potential biomarker?. JOURNAL OF PSYCHIATRIC RESEARCH, v. 47, n. 5, p. 657-663, MAY 2013. Web of Science Citations: 16. (09/17726-9, 11/50740-5, 10/01394-4)
MARTINS, LAYLA FARAGE; ANTUNES, LUCIANA PRINCIPAL; PASCON, RENATA C.; FRANCO DE OLIVEIRA, JULIO CEZAR; DIGIAMPIETRI, LUCIANO A.; BARBOSA, DEIBS; PEIXOTO, BRUNO MALVEIRA; VALLIM, MARCELO A.; VIANA-NIERO, CRISTINA; OSTROSKI, ERIC H.; et al. Metagenomic Analysis of a Tropical Composting Operation at the Sao Paulo Zoo Park Reveals Diversity of Biomass Degradation Functions and Organisms. PLoS One, v. 8, n. 4, APR 24 2013. Web of Science Citations: 55.
MACHADO, MAURÍCIO F. M.; RIOLI, VANESSA; DALIO, FERNANDA M.; CASTRO, LEANDRO M.; JULIANO, MARIA A.; TERSARIOL, IVARNE L.; FERRO, EMER S.; JULIANO, LUIZ; OLIVEIRA, VITOR. The role of Tyr(605) and Ala(607) of thimet oligopeptidase and Tyr(606) and Gly(608) of neurolysin in substrate hydrolysis and inhibitor binding. Biochemical Journal, v. 404, n. 2, p. 279-288, June 2007.
FARIAS, SHIRLEY L.; GAZARINI, MARCOS L.; MELO, ROBSON L.; HIRATA, IZAURA Y.; JULIANO, MARIA A.; JULIANO, LUIZ; GARCIA, CÉLIA R. S.. Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium. Molecular and Biochemical Parasitology, v. 141, n. 1, p. 71-79, May 2005. (02/06194-7, 03/09994-7)
CARMONA, ADRIANA K.; SCHWAGER, SYLVA L.; JULIANO, MARIA A.; JULIANO, LUIZ; STURROCK, EDWARD D.. A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay. Nature Protocols, v. 1, n. 4, p. 1971-1976, Nov. 2006. (03/09994-7)
PASCHOALIN, THAYSA; MARTENS, ADAM A.; OMORI, ALVARO T.; PEREIRA, FELIPE V.; JULIANO, LUIZ; TRAVASSOS, LUIZ R.; MACHADO-SANTELLI, GLAUCIA M.; CUNHA, RODRIGO L. O. R.. Antitumor effect of chiral organotelluranes elicited in a murine melanoma model. Bioorganic & Medicinal Chemistry, v. 27, n. 12, SI, p. 2537-2545, JUN 15 2019. Web of Science Citations: 0. (09/53840-0)
NAVARRO-MUNOZ, JORGE C.; SELEM-MOJICA, NELLY; MULLOWNEY, MICHAEL W.; KAUTSAR, SATRIA A.; TRYON, JAMES H.; PARKINSON, I, ELIZABETH; DE LOS SANTOS, EMMANUEL L. C.; YEONG, MARLEY; CRUZ-MORALES, PABLO; ABUBUCKER, SAHAR; et al. A computational framework to explore large-scale biosynthetic diversity. Nature Chemical Biology, v. 16, n. 1, p. 60+, JAN 2020. Web of Science Citations: 3. (17/08038-8)
RAMOS, PATRICIA L.; KONDO, MARCIA Y.; SANTOS, SAARA M. B.; DE VASCONCELLOS, SUZAN P.; ROCHA, RAFAEL C. S.; DA CRUZ, JOAO B.; EUGENIO, PATRICIA F. M.; CABRAL, HAMILTON; JULIANO, MARIA A.; JULIANO, LUIZ; et al. A Tropical Composting Operation Unit at SAo Paulo Zoo as a Source of Bacterial Proteolytic Enzymes. Applied Biochemistry and Biotechnology, v. 187, n. 1, p. 282-297, JAN 2019. Web of Science Citations: 2. (11/06548-2, 12/50191-4, 13/12106-8, 14/07037-0)
GADELHA, ARY; MACHADO, MAURICIO F. M.; YONAMINE, CAMILA M.; SATO, JOAO R.; JULIANO, MARIA A.; OLIVEIRA, VITOR; BRESSAN, RODRIGO A.; HAYASHI, MIRIAN A. F.. Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia - A potential biomarker?. JOURNAL OF PSYCHIATRIC RESEARCH, v. 47, n. 5, p. 657-663, MAY 2013. Web of Science Citations: 16. (09/17726-9, 11/50740-5, 10/01394-4)
MARTINS, LAYLA FARAGE; ANTUNES, LUCIANA PRINCIPAL; PASCON, RENATA C.; FRANCO DE OLIVEIRA, JULIO CEZAR; DIGIAMPIETRI, LUCIANO A.; BARBOSA, DEIBS; PEIXOTO, BRUNO MALVEIRA; VALLIM, MARCELO A.; VIANA-NIERO, CRISTINA; OSTROSKI, ERIC H.; et al. Metagenomic Analysis of a Tropical Composting Operation at the Sao Paulo Zoo Park Reveals Diversity of Biomass Degradation Functions and Organisms. PLoS One, v. 8, n. 4, APR 24 2013. Web of Science Citations: 55.
MACHADO, MAURÍCIO F. M.; RIOLI, VANESSA; DALIO, FERNANDA M.; CASTRO, LEANDRO M.; JULIANO, MARIA A.; TERSARIOL, IVARNE L.; FERRO, EMER S.; JULIANO, LUIZ; OLIVEIRA, VITOR. The role of Tyr(605) and Ala(607) of thimet oligopeptidase and Tyr(606) and Gly(608) of neurolysin in substrate hydrolysis and inhibitor binding. Biochemical Journal, v. 404, n. 2, p. 279-288, June 2007.
(References retrieved automatically from State of São Paulo Research Institutions)
JÚDICE, Wagner Alves de Souza. Propriedades hidrolíticas de cisteíno-peptidases recombinantes de tripanossomatídeos. xi,133 f. Tese (Doutorado) - Escola Paulista de Medicina. Universidade Federal de São Paulo (UNIFESP). São Paulo. (99/11153-3)
GOUVEA, Iuri Estrada. Propriedades hidrolíticas de Cisteíno peptidase 3C de picornavírus. 63 f. Dissertação (Mestrado) - Escola Paulista de Medicina. Universidade Federal de São Paulo (UNIFESP). São Paulo. (02/10656-6)