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Alexandre Alarcon Steiner

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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Dr. Steiner did his undergraduate and graduate training at the University of Sao Paulo (Brazil), having obtained his PharmD in 1999 and his PhD in Physiology in 2002. He did his postdoctoral training at Joseph?s Hospital & Medical Center (Phoenix, AZ, USA) from 2002 to 2007. His first faculty appointment was as an Assistant Professor at the Albany College of Pharmacy & Health Sciences (Albany, NY, USA), where he stayed until 2012. Since then, Dr. Steiner has been a faculty member in Immunology at the Institute of Biomedical Sciences of the University of Sao Paulo, where he currently occupies an Associate Professor position. The Steiner laboratory studies the multilateral interactions among immune system and physiological systems in life-threatening infections (sepsis) and systemic inflammation. The overall goal is to identify the mechanisms by which these systems cooperate or compete with each other under different contexts. Many, but certainly not all, of the cooperative mechanisms rely on the central nervous system as an integrator of immune, physiological and environmental clues. Currently, Dr. Steiner?s research projects fall in one of three lines of investigation: (i) Tissue-specific functions of resident macrophages, their crosstalk, and their neuroendocrine modulation; (ii) Cost-benefit relationship of fever versus hypothermia in bacterial sepsis and fungal infections; (iii) Hemodynamics of septic shock. E-mail: asteiner@usp.br. (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher
Novel approach to understanding of immune system could lead to personalized therapy against sepsis  
Articles published in other media outlets (29 total):
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Sempre Família: Tratar febre no início da Covid-19 dificulta imunidade de rebanho, diz pesquisador (02/Nov/2020)
Câmara Municipal de São Paulo: Capital fecha a quarta-feira com 13,3 mil mortes e 352,9 mil casos confirmados de Covid-19 (22/Oct/2020)
Saber Atualizado: Cientista da USP critica o combate à febre em estágios iniciais da COVID-19 (21/Oct/2020)
UOL: Em estágios iniciais da covid-19, febre pode ser aliada contra a doença (19/Oct/2020)
NE10: Em estágios iniciais da covid-19, febre pode ser grande aliada contra a doença, afirma estudo (19/Oct/2020)
Jornal da Ciência online: Em estágios iniciais da covid-19, febre pode ser grande aliada contra a doença, afirma estudo (19/Oct/2020)
Agora RN online: Em estágios iniciais da Covid-19, febre pode ser grande aliada contra a doença (19/Oct/2020)
Revista Pará: Em estágios iniciais da Covid-19, febre pode ser grande aliada contra a doença (19/Oct/2020)
ABIPTI - Associação Brasileira das Instituições de Pesquisa Tecnológica e Inovação: Artigo questiona combate à febre em estágios iniciais da COVID-19 (19/Oct/2020)
Portal da Enfermagem: Em estágios iniciais da COVID-19, febre pode ser grande aliada contra a doença, afirma estudo (19/Oct/2020)
Saber Atualizado: Cientistas Brasileiros propõem nova teoria relacionando febre e hipotermia (01/Feb/2020)
Espaço Ecológico no Ar: Combinação de febre e hipotermia pode ajudar a combater a sepse (31/Jan/2020)
Sitios Fuente (México): Revelan por qué una cepa bacteriana es una amenaza en muchos países pero no en Brasil (31/Jan/2020)
UOL: Combinação de febre e hipotermia pode ajudar a combater a sepse (30/Jan/2020)
Planeta Universitário: Combinação de febre e hipotermia pode ajudar a combater a sepse (30/Jan/2020)
Blog Jornal da Mulher: Combinação de febre e hipotermia pode ajudar a combater a sepse (30/Jan/2020)
Portal da Enfermagem: Combinação de febre e hipotermia pode ajudar a combater a sepse (30/Jan/2020)
Central das Notícias: Combinação de febre e hipotermia pode ajudar a combater a sepse (30/Jan/2020)
Brasil CT&I: Combinação de febre e hipotermia pode ajudar a combater a sepse (30/Jan/2020)
Infosalus (Espanha): Un nuevo enfoque del sistema inmune podría llevar a una terapia personalizada contra la sepsis, según un estudio (29/Jan/2020)
Medindia (Índia): New Approach to Treat Sepsis Discovered (28/Jan/2020)
Bajaprogofficial.com: Novel approach to immune system could lead to personalized therapy against sepsis (26/Jan/2020)
News Medical (Austrália): Combination of two immune defense strategies could afford alternative approach to treating sepsis (23/Jan/2020)
Medical Xpress (Reino Unido): Novel approach to immune system could lead to personalized therapy against sepsis (23/Jan/2020)
Science Codex: Novel approach to immune system could lead to personalized therapy against sepsis (23/Jan/2020)
Scienmag Science Magazine (Reino Unido): Novel approach to immune system could lead to personalized therapy against sepsis (23/Jan/2020)
Healthcare: Novel Approach to Immune System Could Lead to Personalized Therapy Against Sepsis (23/Jan/2020)
My Pharmacy News: Novel approach to immune system could lead to personalized therapy against sepsis (23/Jan/2020)
Hekim.pro Doctor (Azerbaijão): Novel approach to immune system could lead to personalized therapy against sepsis (23/Jan/2020)
Research grants
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Scholarships abroad
FAPESP support in numbers * Updated May 01, 2021
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications8
Citations35
Cit./Article4.4
Data from Web of Science

KOMEGAE, EVILIN N.; FONSECA, MONIQUE T.; CRUZ-MACHADO, SANSERAY DA SILVEIRA; TURATO, WALTER M.; FILGUEIRAS, LUCIANO R.; MARKUS, REGINA P.; STEINER, ALEXANDRE A.. Site-Specific Reprogramming of Macrophage Responsiveness to Bacterial Lipopolysaccharide in Obesity. FRONTIERS IN IMMUNOLOGY, v. 10, . Web of Science Citations: 0. (12/03831-8, 18/03418-0, 14/03719-9, 13/13691-1, 15/04557-5, 16/04921-1, 17/13350-0, 14/17407-9)

BARROS, MICHELE S.; LARA, PRISCILA G.; FONSECA, MONIQUE T.; MORETTI, EDUARDO H.; FILGUEIRAS, LUCIANO R.; MARTINS, JOILSON O.; CAPURRO, MARGARETH L.; STEINER, ALEXANDRE A.; SA-NUNES, ANDERSON. Aedes aegypti saliva impairs M1-associated proinflammatory phenotype without promoting or affecting M2 polarization of murine macrophages. PARASITES & VECTORS, v. 12, . Web of Science Citations: 1. (17/11540-7, 15/22934-0, 13/12467-0, 16/04921-1)

CARVALHO, VANESSA F. M.; SALATA, GIOVANNA C.; DE MATOS, JENYFFER K. R.; COSTA-FERNANDEZ, SANDRA; CHORILLI, MARLUS; STEINER, ALEXANDRE A.; DE ARAUJO, GABRIEL L. B.; SILVEIRA, EDILBERTO R.; COSTA-LOTUFO, V, LETICIA; LOPES, LUCIANA B.. Optimization of composition and obtainment parameters of biocompatible nanoemulsions intended for intraductal administration of piplartine (piperlongumine) and mammary tissue targeting. International Journal of Pharmaceutics, v. 567, . Web of Science Citations: 2. (18/18813-1, 13/16617-7, 17/04174-4, 17/23213-0, 18/13877-1, 18/03418-0)

FLATOW, ELIZABETH A.; KOMEGAE, EVILIN N.; FONSECA, MONIQUE T.; BRITO, CAMILA F.; MUSTEATA, FLORIN M.; ANTUNES-RODRIGUES, JOSE; STEINER, ALEXANDRE A.. Elucidating the role of leptin in systemic inflammation: a study targeting physiological leptin levels in rats and their macrophages. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 313, n. 5, p. R572-R582, . Web of Science Citations: 5. (13/09799-1, 12/03831-8, 14/03719-9, 16/04921-1)

FONSECA, MONIQUE T.; RODRIGUES, ABNER C.; CEZAR, LUANA C.; FUJITA, ANDRE; SORIANO, FRANCISCO G.; STEINER, ALEXANDRE A.. Spontaneous hypothermia in human sepsis is a transient, self-limiting, and nonterminal response. Journal of Applied Physiology, v. 120, n. 12, p. 1394-1401, . Web of Science Citations: 10. (09/15530-0, 14/09576-5, 12/03831-8, 13/00506-1, 11/50761-2)

DANTONIO, VALTER; BATALHAO, MARCELO E.; FERNANDES, MARCIA H. M. R.; KOMEGAE, EVILIN N.; BUQUI, GABRIELA A.; LOPES, NORBERTO P.; GARGAGLIONI, LUCIANE H.; CARNIO, EVELIN C.; STEINER, ALEXANDRE A.; BICEGO, KENIA C.. Nitric oxide and fever: immune-to-brain signaling vs. thermogenesis in chicks. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 310, n. 10, p. R896-R905, . Web of Science Citations: 3. (12/19966-0, 13/13386-4, 14/50265-3, 14/13586-6, 12/03831-8)

STEINER, ALEXANDRE A.; FLATOW, ELIZABETH A.; BRITO, CAMILA F.; FONSECA, MONIQUE T.; KOMEGAE, EVILIN N.. Respiratory gas exchange as a new aid to monitor acidosis in endotoxemic rats: relationship to metabolic fuel substrates and thermometabolic responses. PHYSIOLOGICAL REPORTS, v. 5, n. 1, . Web of Science Citations: 1. (12/03831-8, 14/03719-9, 16/04921-1)

CORRIGAN, JOSHUA J.; FONSECA, MONIQUE T.; FLATOW, ELIZABETH A.; LEWIS, KEVIN; STEINER, ALEXANDRE A.. Hypometabolism and hypothermia in the rat model of endotoxic shock: independence of circulatory hypoxia. JOURNAL OF PHYSIOLOGY-LONDON, v. 592, n. 17, p. 3901-3916, . Web of Science Citations: 13. (12/03831-8)

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