CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate at Licenciatura em Ciências Biológicas from Universidade Federal do Espírito Santo (1996), master's at Genetics from Universidade Estadual de Campinas (2000) and ph.d. at Genetics from Universidade Estadual de Campinas (2004). Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: pituitary tumors, genetics and epigenetics, and Kallmann syndrome. (Source: Lattes Curriculum)
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Prolactin-secreting pituitary tumors (PRL) (prolactinomas) are the most prelevant pituitary tumors and its first line treatment are dopaminergic agonists (DA), being effective in about 80% of cases. However, the remaining 20% partial or total resistance to these drugs require alternative treatment. PRL binds to its receptor (PRLR), a member of the cytokine receptor family and activates si…
Clinically nonfunctioning pituitary adenomas (ACNF) represent about 30% of pituitary tumors. Are diagnosed early as incidentalomas sellar or later, when they reach sufficient size to cause compressive symptoms neuroftalmológicos and / or hypopituitarism. Macroadenomas (> 1 cm), treatment of choice for most patients is surgical resection. Although surgery can improve the visual change and …
Multinodular goiter (MNG) is defined as an enlargement of the thyroid gland that is characterized by heterogeneity in growth and function of thyroid follicular cells. It is a benign and very common disease. Constitutive activation of the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway, including PTEN loss of expression, in follicular cells has been frequently involved in …
(Only some records are available in English at this moment)
Multinodular goiter (MNG) is defined as an enlargement of the thyroid gland that is characterized by heterogeneity in growth and function of thyroid follicular cells. It is a benign and very common disease. Constitutive activation of the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway, including PTEN loss of expression, in follicular cells has been frequently involved in …
Nonfunctioning pituitary adenomas (NFPA) are the most frequent pituitary tumors. These tumors received this definition because they do not result in anterior pituitary hormonal hypersecretion or a clinical hormone-excess syndrome, and their diagnosis rests on the clinical recognition of compressive symptoms. Somatostatin (SRIF) and dopamine (DA) are two critical regulators of pituitary ce…
Pheochromocytomas (PHEOs) are neuroendocrine catecholamine-producing tumors that shown hypertension as the most common medical complication. Usually, PHEOS are sporadic and about 30% of these tumors harbor germinative mutations in genes like RET, VHL, SDHB, SDHC e SDHD. The von Hippel-Lindau disease is caused by mutations in VHL gene. The proteins codified by SDHB, SDHC e SDHD genes are m…
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 7 / 3 | Completed scholarships in Brazil |
| 12 / 8 | All research grants and scholarships |
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