CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate at Faculty of Pharmacy, Sao Paulo University(1979), Sao Paulo, Brasil, master's at Pharmacology, Sao Paulo University (1982) and pH.D. at Pharmacology at Biomedical Sci. Institute, Sao Paulo University (1990). She is currently scientific researcher at Butantan Institute, Sao Paulo, SP. Has experience in Toxinology and Pharmacology, acting on the following subjects: inflammatory and antiinflammatory effects of animal venoms, venom phospholipases A2 and metalloproteinases, focusing on signaling pathways and molecular mechanisms triggered by venoms and toxins in inflammatory cells. (Source: Lattes Curriculum)
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Successful drug development requires a disease target that plays a vital role in the causation and/or progression of the disease phenotype and that can be modulated with a drug molecule. In other words, therapeutically relevant targets are both “disease-modifying” and “druggable”. It has been estimated that around 10% of the entire human genome is involved in disease onset or progression,…
Secreted phospholipases A2 (sPLA2s) are major components of Bothrops snake venoms. These enzymes present high grade of homology with mammalian GIIA-PLA2s, which are markedly increased during inflammatory diseases such as atherosclerosis. Therefore, these snake enzymes constitute valuable tools for studies on the effects of mammalian inflammatory sPLA2s. MT-III, a GII-A Asp49-sFLA2 isola…
Bothrops genus snake venoms contain high amounts of secretory phospholipases A2 (sFLA2) with high grade of structural and functional homology with mammalian sFLA2, which are increased in inflammatory diseases, such as atherosclerosis. We have recently shown that MT-III, a group IIA venom sFLA2 is able to directly induce lipid body formation and ADRP expression in macrophages. ADRP is a ke…
(Only some records are available in English at this moment)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by sustained synovitis. Moreover, this disease is primarily characterized by joint pain, swelling, stiffness, and accompanied by skeletal muscle wasting. Patients with RA suffer from loss of skeletal muscle mass or rheumatoid cachexia, which includes wasting of skeletal muscle tissue. Although the mechanism for the …
Snake venoms of the Viperidae family contain proteinases of the metalloproteinases class, with potent inflammatory activity. These enzymes exhibit structural and functional homology with mammalian metalloproteinases (MMPs) whose levels are elevated in serum and joint fluid of patients with inflammatory arthropathies. Thus, venom metalloproteinases are useful tools for elucidating the acti…
The transcriptional modulation of pain-related genes in co-cultures of 3D neural spheroids (neurons, glial cells and Schwan cells) and 3D mimic of cartilage microenvironment (cultured with chondrocytes, synovicytes and macrophages) will be studied by RT_PCR arrays. The double 3D co-culture model allows for the in vitro modelling of the complex environment of joints and the peripheral noci…
Animal toxins play a singular role in the biomedical sciences. During the evolutionary process, animal toxins suffered a complexification of their chemical structures in response to specific targets of their prey. Thereby, the toxins purified from snake venoms have been used as critical scientific tools to studies of physiological and pathophysiological mechanisms and processes, among oth…
(Only some records are available in English at this moment)
Phospholipases A2 (PLA2s) are abundant in snake venoms and have been widely employed as pharmacological tools to investigate the role of this class of enzymes in diverse pathophysiological processes. MT-III, an Asp49 PLA2 isolated from Bothrops asper snake venom is classified into the group IIA sPLA2s. Mammalian GIIA-PLA2s are highly expressed in vascular smooth muscle cells (VSMCs) and t…
Bothrops venoms contain high concentrations of secreted phospholipases A2 (sPLA2) which have structural and functional homology with mammalian PLA2s, whose levels are increased in inflammatory diseases such as atherosclerosis. We have recently demonstrated that MT-III, a sPLA2 group IIA, induced an increase in lipid body formation and expression of adipofilina (ADRP) or PLIN2, a protein i…
| 1 / 1 | Ongoing research grants |
| 15 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 25 / 8 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 45 / 17 | All research grants and scholarships |
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