CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate at Faculty of Pharmacy, Sao Paulo University(1979), Sao Paulo, Brasil, master's at Pharmacology, Sao Paulo University (1982) and pH.D. at Pharmacology at Biomedical Sci. Institute, Sao Paulo University (1990). She is currently scientific researcher at Butantan Institute, Sao Paulo, SP. Has experience in Toxinology and Pharmacology, acting on the following subjects: inflammatory and antiinflammatory effects of animal venoms, venom phospholipases A2 and metalloproteinases, focusing on signaling pathways and molecular mechanisms triggered by venoms and toxins in inflammatory cells. (Source: Lattes Curriculum)
Successful drug development requires a disease target that plays a vital role in the causation and/or progression of the disease phenotype and that can be modulated with a drug molecule. In other words, therapeutically relevant targets are both “disease-modifying” and “druggable”. It has been estimated that around 10% of the entire human genome is involved in disease onset or progression,…
Secreted phospholipases A2 (sPLA2s) are major components of Bothrops snake venoms. These enzymes present high grade of homology with mammalian GIIA-PLA2s, which are markedly increased during inflammatory diseases such as atherosclerosis. Therefore, these snake enzymes constitute valuable tools for studies on the effects of mammalian inflammatory sPLA2s. MT-III, a GII-A Asp49-sFLA2 isola…
Bothrops genus snake venoms contain high amounts of secretory phospholipases A2 (sFLA2) with high grade of structural and functional homology with mammalian sFLA2, which are increased in inflammatory diseases, such as atherosclerosis. We have recently shown that MT-III, a group IIA venom sFLA2 is able to directly induce lipid body formation and ADRP expression in macrophages. ADRP is a ke…
(Only some records are available in English at this moment)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by sustained synovitis. Moreover, this disease is primarily characterized by joint pain, swelling, stiffness, and accompanied by skeletal muscle wasting. Patients with RA suffer from loss of skeletal muscle mass or rheumatoid cachexia, which includes wasting of skeletal muscle tissue. Although the mechanism for the …
Snake venoms of the Viperidae family contain proteinases of the metalloproteinases class, with potent inflammatory activity. These enzymes exhibit structural and functional homology with mammalian metalloproteinases (MMPs) whose levels are elevated in serum and joint fluid of patients with inflammatory arthropathies. Thus, venom metalloproteinases are useful tools for elucidating the acti…
The transcriptional modulation of pain-related genes in co-cultures of 3D neural spheroids (neurons, glial cells and Schwan cells) and 3D mimic of cartilage microenvironment (cultured with chondrocytes, synovicytes and macrophages) will be studied by RT_PCR arrays. The double 3D co-culture model allows for the in vitro modelling of the complex environment of joints and the peripheral noci…
Animal toxins play a singular role in the biomedical sciences. During the evolutionary process, animal toxins suffered a complexification of their chemical structures in response to specific targets of their prey. Thereby, the toxins purified from snake venoms have been used as critical scientific tools to studies of physiological and pathophysiological mechanisms and processes, among oth…
(Only some records are available in English at this moment)
Phospholipases A2 (PLA2s) are abundant in snake venoms and have been widely employed as pharmacological tools to investigate the role of this class of enzymes in diverse pathophysiological processes. MT-III, an Asp49 PLA2 isolated from Bothrops asper snake venom is classified into the group IIA sPLA2s. Mammalian GIIA-PLA2s are highly expressed in vascular smooth muscle cells (VSMCs) and t…
Bothrops venoms contain high concentrations of secreted phospholipases A2 (sPLA2) which have structural and functional homology with mammalian PLA2s, whose levels are increased in inflammatory diseases such as atherosclerosis. We have recently demonstrated that MT-III, a sPLA2 group IIA, induced an increase in lipid body formation and expression of adipofilina (ADRP) or PLIN2, a protein i…
| 1 / 1 | Ongoing research grants |
| 15 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 25 / 8 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 45 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 25 |
| Citations | 171 |
| Cit./Article | 6.8 |
| Data from Web of Science | |
SILVA, CARLOS A.; ZULIANI, JULIANA P.; ASSAKURA, MARINA T.; MENTELE, REINHARD; CAMARGO, ANTONIO C. M.; TEIXEIRA, CATARINA F. P.; SERRANO, SOLANGE M. T.. Activation of alpha(M)beta(2)-mediated phagocytosis by HF3, a P-III class metalloproteinase isolated from the venom of Bothrops jararaca. Biochemical and Biophysical Research Communications, v. 322, n. 3, p. 950-956, Sept. 2004. (98/14307-9)
ZULIANI, JULIANA P.; FERNANDES, CRISTINA M.; ZAMUNER, STELLA R.; GUTIÉRREZ, JOSÉ M.; TEIXEIRA, CATARINA F. P.. Inflammatory events induced by Lys-49 and Asp-49 phospholipases A(2) isolated from Bothrops asper snake venom: role of catalytic activity. Toxicon, v. 45, n. 3, p. 335-346, Mar. 2005.
TEIXEIRA, C. F. P.; LANDUCCI, E. C. T.; ANTUNES, E.; CHACUR, M.; CURY, Y.. Inflammatory effects of snake venom myotoxic phospholipases A(2). Toxicon, v. 42, n. 8, p. 947-962, Dec. 2003.
MOREIRA, VANESSA; GUTIERREZ, JOSE MARIA; SOARES, ANDREIMAR MARTINS; ZAMUNER, STELLA REGINA; PURGATTO, EDUARDO; PEREIRA TEIXEIRA, CATARINA DE FATIMA. Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E-2 and D-2 and expression of cyclooxygenases. Toxicon, v. 52, n. 3, p. 428-439, SEP 1 2008. Web of Science Citations: 28.
GIANNOTTI, KARINA CRISTINA; LEIGUEZ, ELBIO; MOREIRA, VANESSA; NASCIMENTO, NEIDE GALVAO; LOMONTE, BRUNO; MARIA GUTIERREZ, JOSE; DE MELO, ROBSON LOPES; TEIXEIRA, CATARINA. A Lys49 Phospholipase A(2), Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region. BIOMED RESEARCH INTERNATIONAL, 2013. Web of Science Citations: 11. (07/03337-5, 11/21341-5, 10/06345-1)
MOREIRA, VANESSA; GUTIERREZ, JOSE MARIA; AMARAL, RAFAELA BACCI; ZAMUNER, STELLA REGINA; PEREIRA TEIXEIRA, CATARINA DE FATIMA. Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, v. 80, n. 2-3, p. 107-114, FEB-MAR 2009. Web of Science Citations: 9.
MOREIRA, VANESSA; DOS-SANTOS, MARIA CRISTINA; NASCIMENTO, NEIDE GALVAO; DA SILVA, HENRIQUE BORGES; FERNANDES, CRISTINA MARIA; D'IMPERIO LIMA, MARIA REGINA; TEIXEIRA, CATARINA. Local inflammatory events induced by Bothrops atrox snake venom and the release of distinct classes of inflammatory mediators. Toxicon, v. 60, n. 1, p. 12-20, JUL 2012. Web of Science Citations: 29. (09/08559-1, 10/51150-4, 07/03337-5)
ZAMUNER‚ S.R.; GUTIÉRREZ‚ J.M.; MUSCARÁ‚ M.N.; TEIXEIRA‚ S.A.; TEIXEIRA‚ C.F.P.. Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo. Toxicon, v. 39, n. 10, p. 1505-1513, 2001.
MOREIRA‚ V.; ZAMUNER‚ S.R.; WALLACE‚ J.L.; TEIXEIRA‚ C.F.P.. Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2‚ and expression of cyclooxygenases. Toxicon, v. 49, n. 5, p. 615-624, 2007.
OLIVO‚ R.A.; TEIXEIRA‚ C.F.P.; SILVEIRA‚ P.F.. Representative aminopeptidases and prolyl endopeptidase from murine macrophages: comparative activity levels in resident and elicited cells. Biochemical Pharmacology, v. 69, n. 10, p. 1441-1450, 2005.
TEIXEIRA‚ CFP; ZAMUNER‚ SR; ZULIANI‚ JP; FERNANDES‚ CM; CRUZ-HOFLING‚ MA; FERNANDES‚ I.; CHAVES‚ F.; GUTIERREZ‚ JM. Neutrophils do not contribute to local tissue damage‚ but play a key role in skeletal muscle regeneration‚ in mice injected with Bothrops asper snake venom. MUSCLE & NERVE, v. 28, n. 4, p. 449-459, 2003.
CASAIS-E-SILVA, LUCIANA LYRA; TEIXEIRA, CATARINA. Neurogenic mediators contribute to local edema induced by Micrurus lemniscatus venom. PLoS Neglected Tropical Diseases, v. 11, n. 11, NOV 2017. Web of Science Citations: 1. (14/18549-1)
ZULIM DE CARVALHO, ANA EDUARDA; GIANNOTTI, KARINA; LEIGUEZ JUNIOR, ELBIO; MATSUBARA, MARCIO; DOS SANTOS, MARIA CRISTINA; FORTES-DIAS, CONSUELO LATORRE; TEIXEIRA, CATARINA. Crotalus durissus ruruima Snake Venom and a Phospholipase A(2) Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, NOV 4 2019. Web of Science Citations: 0. (15/24701-3, 14/18549-1, 18/05637-0, 15/50040-4)
LEIGUEZ, ELBIO; GIANNOTTI, KARMA CRISTINA; VIANA, MARIANA DO NASCIMENTO; MATSUBARA, MARCIO HIDEKI; FERNANDES, CRISTINA MARIA; GUTIERREZ, JOSE MARIA; LOMONTE, BRUNO; TEIXEIRA, CATARINA. A Snake Venom-Secreted Phospholipase A(2) Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis. Mediators of Inflammation, 2018. Web of Science Citations: 0. (11/21341-5, 15/24701-3, 14/18549-1, 13/22610-5, 10/08506-2, 10/06345-1)
MOREIRA, VANESSA; TEIXEIRA, CATARINA; DA SILVA, HENRIQUE BORGES; D'IMPERIO LIMA, MARIA REGINA; DOS-SANTOS, MARIA CRISTINA. The role of TLR2 in the acute inflammatory response induced by Bothrops atrox snake venom. Toxicon, v. 118, p. 121-128, AUG 2016. Web of Science Citations: 5. (13/07140-2, 11/21341-5, 14/00810-5)
VIANA, MARIANA N.; LEIGUEZ, ELBIO; GUTIERREZ, JOSE M.; RUCAVADO, ALEXANDRA; MARKUS, REGINA P.; MARCOLA, MARINA; TEIXEIRA, CATARINA; FERNANDES, CRISTINA M.. A representative metalloprotease induces PGE(2) synthesis in fibroblast-like synoviocytes via the NF-kappa B/COX-2 pathway with amplification by IL-1 beta and the EP4 receptor. SCIENTIFIC REPORTS, v. 10, n. 1, FEB 24 2020. Web of Science Citations: 0. (15/50040-4)
ZULIANI, JULIANA PAVAN; MARIA GUTIERREZ, JOSE; TEIXEIRA, CATARINA. Signaling pathways involved in zymosan phagocytosis induced by two secreted phospholipases A(2) isolated from Bothrops asper snake venom in macrophages. International Journal of Biological Macromolecules, v. 113, p. 575-582, JUL 1 2018. Web of Science Citations: 2.
NASCIMENTO, NEIDE GALVAO; SAMPAIO, MARLOS CORTEZ; OLIVO, RENATA AMARAL; TEIXEIRA, CATARINA. Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. Toxicon, v. 55, n. 2-3, p. 343-352, FEB-MAR 2010. Web of Science Citations: 31.
LEIGUEZ, ELBIO; ZULIANI, JULIANA PAVAN; CIANCIARULLO, AURORA MARQUES; FERNANDES, CRISTINA MARIA; MARIA GUTIERREZ, JOSE; TEIXEIRA, CATARINA. A group IIA-secreted phospholipase A(2) from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A(2) and distinct signaling pathways. Journal of Leukocyte Biology, v. 90, n. 1, p. 155-166, JUL 2011. Web of Science Citations: 13.
LEIGUEZ, ELBIO; GIANNOTTI, KARINA CRISTINA; MOREIRA, VANESSA; MATSUBARA, MARCIO HIDEKI; MARIA GUTIERREZ, JOSE; LOMONTE, BRUNO; PABLO RODRIGUEZ, JUAN; BALSINDE, JESUS; TEIXEIRA, CATARINA. Critical Role of TLR2 and MyD88 for Functional Response of Macrophages to a Group IIA-Secreted Phospholipase A(2) from Snake Venom. PLoS One, v. 9, n. 4, APR 9 2014. Web of Science Citations: 5. (11/21341-5, 10/06345-1)
LEIGUEZ, ELBIO; ZULIANI, JULIANA PAVAN; CIANCIARULLO, AURORA MARQUES; FERNANDES, CRISTINA MARIA; MARIA GUTIERREZ, JOSE; TEIXEIRA, CATARINA. A group IIA-secreted phospholipase A(2) from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A(2) and distinct signaling pathways. Journal of Leukocyte Biology, v. 90, n. 1, p. 155-166, JUL 2011. Web of Science Citations: 13.
NASCIMENTO, NEIDE GALVAO; SAMPAIO, MARLOS CORTEZ; OLIVO, RENATA AMARAL; TEIXEIRA, CATARINA. Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. Toxicon, v. 55, n. 2-3, p. 343-352, FEB-MAR 2010. Web of Science Citations: 31.
ZULIM DE CARVALHO, ANA EDUARDA; GIANNOTTI, KARINA; LEIGUEZ JUNIOR, ELBIO; MATSUBARA, MARCIO; DOS SANTOS, MARIA CRISTINA; FORTES-DIAS, CONSUELO LATORRE; TEIXEIRA, CATARINA. Crotalus durissus ruruima Snake Venom and a Phospholipase A(2) Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, NOV 4 2019. Web of Science Citations: 0. (15/24701-3, 14/18549-1, 18/05637-0, 15/50040-4)
LEIGUEZ, ELBIO; GIANNOTTI, KARMA CRISTINA; VIANA, MARIANA DO NASCIMENTO; MATSUBARA, MARCIO HIDEKI; FERNANDES, CRISTINA MARIA; GUTIERREZ, JOSE MARIA; LOMONTE, BRUNO; TEIXEIRA, CATARINA. A Snake Venom-Secreted Phospholipase A(2) Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis. Mediators of Inflammation, 2018. Web of Science Citations: 0. (11/21341-5, 15/24701-3, 14/18549-1, 13/22610-5, 10/08506-2, 10/06345-1)
CASAIS-E-SILVA, LUCIANA LYRA; TEIXEIRA, CATARINA. Neurogenic mediators contribute to local edema induced by Micrurus lemniscatus venom. PLoS Neglected Tropical Diseases, v. 11, n. 11, NOV 2017. Web of Science Citations: 1. (14/18549-1)
ZULIANI, JULIANA PAVAN; MARIA GUTIERREZ, JOSE; TEIXEIRA, CATARINA. Signaling pathways involved in zymosan phagocytosis induced by two secreted phospholipases A(2) isolated from Bothrops asper snake venom in macrophages. International Journal of Biological Macromolecules, v. 113, p. 575-582, JUL 1 2018. Web of Science Citations: 2.
MOREIRA, VANESSA; DOS-SANTOS, MARIA CRISTINA; NASCIMENTO, NEIDE GALVAO; DA SILVA, HENRIQUE BORGES; FERNANDES, CRISTINA MARIA; D'IMPERIO LIMA, MARIA REGINA; TEIXEIRA, CATARINA. Local inflammatory events induced by Bothrops atrox snake venom and the release of distinct classes of inflammatory mediators. Toxicon, v. 60, n. 1, p. 12-20, JUL 2012. Web of Science Citations: 29. (10/51150-4, 09/08559-1, 07/03337-5)
MOREIRA, VANESSA; GUTIERREZ, JOSE MARIA; AMARAL, RAFAELA BACCI; ZAMUNER, STELLA REGINA; PEREIRA TEIXEIRA, CATARINA DE FATIMA. Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, v. 80, n. 2-3, p. 107-114, FEB-MAR 2009. Web of Science Citations: 9.
SILVA, CARLOS A.; ZULIANI, JULIANA P.; ASSAKURA, MARINA T.; MENTELE, REINHARD; CAMARGO, ANTONIO C. M.; TEIXEIRA, CATARINA F. P.; SERRANO, SOLANGE M. T.. Activation of alpha(M)beta(2)-mediated phagocytosis by HF3, a P-III class metalloproteinase isolated from the venom of Bothrops jararaca. Biochemical and Biophysical Research Communications, v. 322, n. 3, p. 950-956, Sept. 2004. (98/14307-9)
ZULIANI, JULIANA P.; FERNANDES, CRISTINA M.; ZAMUNER, STELLA R.; GUTIÉRREZ, JOSÉ M.; TEIXEIRA, CATARINA F. P.. Inflammatory events induced by Lys-49 and Asp-49 phospholipases A(2) isolated from Bothrops asper snake venom: role of catalytic activity. Toxicon, v. 45, n. 3, p. 335-346, Mar. 2005.
ZAMUNER‚ S.R.; GUTIÉRREZ‚ J.M.; MUSCARÁ‚ M.N.; TEIXEIRA‚ S.A.; TEIXEIRA‚ C.F.P.. Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo. Toxicon, v. 39, n. 10, p. 1505-1513, 2001.
MOREIRA‚ V.; ZAMUNER‚ S.R.; WALLACE‚ J.L.; TEIXEIRA‚ C.F.P.. Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2‚ and expression of cyclooxygenases. Toxicon, v. 49, n. 5, p. 615-624, 2007.
OLIVO‚ R.A.; TEIXEIRA‚ C.F.P.; SILVEIRA‚ P.F.. Representative aminopeptidases and prolyl endopeptidase from murine macrophages: comparative activity levels in resident and elicited cells. Biochemical Pharmacology, v. 69, n. 10, p. 1441-1450, 2005.
TEIXEIRA, C. F. P.; LANDUCCI, E. C. T.; ANTUNES, E.; CHACUR, M.; CURY, Y.. Inflammatory effects of snake venom myotoxic phospholipases A(2). Toxicon, v. 42, n. 8, p. 947-962, Dec. 2003.
MOREIRA, VANESSA; GUTIERREZ, JOSE MARIA; SOARES, ANDREIMAR MARTINS; ZAMUNER, STELLA REGINA; PURGATTO, EDUARDO; PEREIRA TEIXEIRA, CATARINA DE FATIMA. Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E-2 and D-2 and expression of cyclooxygenases. Toxicon, v. 52, n. 3, p. 428-439, SEP 1 2008. Web of Science Citations: 28.
GIANNOTTI, KARINA CRISTINA; LEIGUEZ, ELBIO; MOREIRA, VANESSA; NASCIMENTO, NEIDE GALVAO; LOMONTE, BRUNO; MARIA GUTIERREZ, JOSE; DE MELO, ROBSON LOPES; TEIXEIRA, CATARINA. A Lys49 Phospholipase A(2), Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region. BIOMED RESEARCH INTERNATIONAL, 2013. Web of Science Citations: 11. (11/21341-5, 07/03337-5, 10/06345-1)
VIANA, MARIANA N.; LEIGUEZ, ELBIO; GUTIERREZ, JOSE M.; RUCAVADO, ALEXANDRA; MARKUS, REGINA P.; MARCOLA, MARINA; TEIXEIRA, CATARINA; FERNANDES, CRISTINA M.. A representative metalloprotease induces PGE(2) synthesis in fibroblast-like synoviocytes via the NF-kappa B/COX-2 pathway with amplification by IL-1 beta and the EP4 receptor. SCIENTIFIC REPORTS, v. 10, n. 1, FEB 24 2020. Web of Science Citations: 0. (15/50040-4)
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVO, Renata Do Amaral. Caracterização de atividades de aminopeptidases e da prolil oligopeptidase em macrófagos murinos e suas alterações induzidas pelos venenos de serpentes Bothrops jararaca (VBj) e Crotalus durissus terrificus (VCdt): estudos in vivo e in vitro. 86 f. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (02/10861-9)