CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Curso de Ciências Biológicas Modalidade Médica from Universidade Federal de São Paulo (1975), master's at Microbiology from Universidade Federal de São Paulo (1978) and doctorate at Microbiology from Universidade Federal de São Paulo (1984). Has experience in Immunology, acting on the following subjects: demyelinating diseases, autoimmune disease, encefalomielite experimental autoimune, autoimunidade and autoimmune diseases. (Source: Lattes Curriculum)
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Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system. This is a major socioeconomic problem, since MS affects mainly young adults (18-40 years), in the most productive phase of life.MS is caused by two mechanisms that overlap inflammation and neurodegeneration. Cortical atrophy, observed since the onset of the disease, may be responsible for the symp…
B lymphocytes actively participate in the pathogenesis of multiple sclerosis, mainly in the progressive forms of the disease. Autoantibodies can cause tissue damage in the neurons contributing to neurodegeneration. B lymphocytes are specific antigen-presenting cells, since neuroantigen is recognized by BCR and processed antigen is presented to CD4 autoreactive T cells. Furthermore, B-lym…
The HLA-G molecules either express on cell surface or in the soluble form play an important role in the induction of immunological tolerance.These molecules are express in various cells type and their involvement in the generation of regulatory T lymphocytes was previously described. The aim of this study is to understand the immunoregulatory function of HLA-G express on plasmacytoid dend…
(Only some records are available in English at this moment)
Multiple Sclerosis (MS) is an autoimmune disease of the Central Nervous System (CNS) characterized by inflammation and neurodegeneration. Inflammation can be initiated by transmigration of autoreactive T lymphocytes and other leukocytes through the Blood-Brain Barrier (BBB), resulting in demyelination, degeneration and axonal damage to the white and gray matter of the CNS; 1) MS usually a…
Multiple Sclerosis (MS) is an autoimmune, chronic and demyelinating disease that affects the Central Nervous System (CNS) of young adults. The oral drug Dimethyl Fumarate (DMF; Dimethyl Fumarate; Tecfidera, Biogen) is a treatment option for relapsing/remitting MS (RRMS). This medicine is converted to its active metabolite, Monomethyl Fumarate (MMF), in the intestine. Despite its beneficia…
A significant advance in the treatment of multiple sclerosis (MS) has marked the last two decades. The arrival of chimeric, humanized and currently fully human monoclonal antibodies has contributed to the attempt to decrease the progress of MS. However, due to a number of problems, not all patients adhere to injectable or infusible treatments. Therefore, in recent years there has been an …
Several studies show that both brain function, including human behavior, and inflammatory response are influenced by microbacterial metabolites generated in the gut; Intestinal microbiota products such as small-chain fatty acids (SCFAs), eg butyric acid, actively control the inflammatory response of mammals through their binding to the HCAR2 receptor expressed primarily in dendritic cells…
(Only some records are available in English at this moment)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). The monoclonal antibody Natalizumab (NTZ) is one of the most used treatment for relapsing/remitting MS. It is well described that NTZ acts by stopping leukocytes from infiltrating the CNS and, therefore, avoiding local tissue damage. However, growing pieces of evidence have been showing that par…
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that is currently attributed to self-sustaining autoimmune mechanisms. Most of the knowledge regarding the autoaggressive mechanisms of MS has been obtained through experiments performed in its murine model, the Experimental Autoimmune Encephalomyelitis (EAE). EAE is considered a CD4+ T-cell med…
In the last years, several effective medications were introduced on the market, called disease modifying therapies, e.g. recombinant interferon beta (INF-²) and glatiramer acetate (GA), but they have a partial control on multiple sclerosis (MS). In 2006, a monoclonal humanized antibody (Natalizumab) that binds to alpha-4 subunit of integrins expressed on activated T cells surface showed a…
| 15 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 35 / 16 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 54 / 25 | All research grants and scholarships |
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