CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Licenciatura Em Ciências Biológicas from Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (1976), master's at Pós Graduação em Genética from Faculdade de Medicina de Ribeirão Preto - USP (1980) and doctorate at Pós graduação em Genética from Faculdade de Medicina de Ribeirão Preto - USP (1986). She is currently associate professor at Universidade de São Paulo. Has experience in Genetics, focusing on Mutagenesis, acting on the following subjects: apoptosis, ionizing radiation, gene expression profiles studied by DNA microarrays. (Source: Lattes Curriculum)
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Alzheimer's disease (AD) is a chronic and complex disease, characterized by progressive and irreversible degeneration of neurons and the dysregulation of multiple cellular pathways. There are still no effective treatments for patients with this disease, with large gaps regarding the molecular mechanisms involved in its development, which require elucidation. Due to the central role of the…
Currently, there are no effective treatments for patients with neurodegenerative diseases. Acetylcholinesterase (AChE) inhibitors are the main drugs used in the clinic for the treatment of Alzheimer's disease (AD), but the drugs presently in use have several limitations. There remains an immense challenge regarding the development of effective compounds with lower cytotoxicity and side ef…
The equipment will be used for a considerable part of the project by several researchers in the group, for analysis of individual genes or gene sets (PCR arrays), as well as by researchers from other laboratories of the Biology department and Genetics department, and also other units of the Campus USP-Ribeirão Preto. There is no similar device in the Lab. of Cytogenetics and Mutagenesis; …
(Only some records are available in English at this moment)
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia caused primarily by insulin resistance (IR) in tissues. In the early stages of the disease, symptoms are often imperceptible, and as chronic hyperglycemia develops with age, various complications and comorbidities arise, including an increased risk (2 to 5 times) for patients to develop Alzheimer's dise…
Alzheimer's disease (AD), characterized by a progressive episodic memory loss, is a cerebral disorder caused by the B-amyloid peptide (AB) deposits (senile plaques) and abnormal tau protein phosphorylation (neurofibrillary tangles) in the brain and therefore, loss of cholinergic function of the central nervous system. It is well known that the impairment of this function due to AB neuroto…
Glioblastoma (GBM) is an aggressive tumor with a discouraging prognosis. The main chemotherapy protocol includes the alkylating agent temozolomide (TMZ). DNA repair pathways, as the one mediated by the MGMT (O6-methylguanine-DNA methyltransferase) enzyme and the Base Excision Repair (BER), promote resistance to base lesions induced by TMZ, constituting a major obstacle to reach therapeuti…
Glioblastoma multiforme (GBM) is a lethal tumor and radiation therapy remains one of the main treatments. New strategies are needed to overcome the resistance to treatment; one of which is based on the inhibition of transcription factors (TFs) activity. There is evidence that E2F family members may be promising targets for anti-cancer therapy due to their functions related to proliferatio…
(Only some records are available in English at this moment)
Glioblastoma (GBM) is a malignant brain tumor with poor outcome and is very resistant to treatment. Glioma stem cell (GSC) presents an enhanced antioxidant defense compared to their serum-differentiated counterparts and is resistant to chemo- and radio- therapy. We propose to analyze some of the most important antioxidant proteins/expressed genes (e.g. gluthathione, glutathione peroxidase…
Oxidative stress seems to be strictly correlated with the development and progression of neurodegenerative diseases and also with the aging process itself. It has been reported that oxidative stress plays a role in the development of Alzheimer's disease (AD), which is a neurodegenerative disease with large impact on public health. Since base excision repair (BER) seems to be the main mech…
| 1 / 1 | Ongoing grants |
| 20 / 11 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 32 / 11 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 56 / 26 | All research grants and scholarships |
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