CV Lattes
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at História Natural from Universidade Estadual Paulista Júlio de Mesquita Filho (1965) and ph.d. at Biologia from Universidade Estadual de Campinas (1975). Has experience in Zoology, focusing on Morphology of the Recent Groups, acting on the following subjects: phoneutria nigriventer, figado, veneno de cobra, rato and rat. (Source: Lattes Curriculum)
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We have previously demonstrated that Phoneutria nigriventer venom (PNV) causes blood-brain barrier (BBB) breakdown, swelling of astrocytes end-feet and fluid permeation into brain interstitium in rats. Caveolae and water channels respond to BBB alterations by co-participation in shear stress response and edema formation/resolution. Herein, we showed post-natal developmental-related change…
Myotoxins present in Bothrops venom disrupt the sarcolemma of muscle fibers 25 leading to the release of sarcoplasmic proteins and loss of muscle homeostasis. Myonecrosis 26 and tissue anoxia induced by vascularization impairment can lead to amputation or motor 27 functional deficit. The objective of this study was to investigate the dynamic behavior of 28 motor function in mice subjected…
Phoneutria nigriventer spider accidental envenomation provokes neurotoxic manifestations, which when critical, results in epileptic-like episodes. In rats, P. nigriventer venom (PNV) causes blood-brain barrier breakdown (BBBb). The PNV-induced excitotoxicity results from disturbances on Na+, K+ and Ca2+ channels and glutamate handling. The vascular endothelial growth factor (VEGF), beyond…
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Pharmacological treatments of neurological disorders are often complicated due to the inability of the drugs to cross the blood brain barrier (BBB). The BBB, although essential for the maintenance of homeostasis of central nervous system (CNS), is the greatest obstacle to the access of therapeutic drugs in the neural microenvironment since it has structural and molecular characteristics t…
In general, the accidents caused by Bothrops snakes affect the skin and muscular soft tissues of the inferior limbs of the victims. The botropic venom presents myotoxic, hemorrhagic and proteolytic effects that are widely known. Experimental data show that the local alterations caused by venom develop very fast due both to a direct action of myotoxins and indirectly by tissue anoxia cause…
It has been shown that the NO-cGMP signaling pathway regulates ion channels opening, protein phosphorylation and expression of transcription factors. In the CNS, NO-cGMP pathway seems to be involved in several events such as synaptic plasticity, increased neuronal coupling and excitability, neuroinflamatory responses, regulation of vascular tone and blood vessels permeability (hence in th…
The blood-brain barrier (BBB) is a complex physical and functional barrier that protects the central nervous system (CNS) from physical and chemical insults. Nevertheless, it also constitutes a barrier against therapeutics for treating CNS diseases. In this context, nanomedicine is a promising field of study to help to overcome this problem. In a previous study, we have demonstrated the d…
The blood-brain barrier (BBB) restricts the access of substances to the central nervous system (CNS). Among the cellular components of the BBB the astrocytes have been specially studied since these glial cells induce and maintain the barrier phenotype typical of the brain endothelium. Moreover, the astrocytes are influenced by endothelium signaling and respond to changes in the neural mic…
| 32 / 17 | Completed research grants |
| 11 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 45 / 22 | All research grants and scholarships |
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