Cristoforo Scavone
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Degree in Pharmacy and Biochemistry from University of São Paulo (USP), Master and PhD in Pharmacology from USP, and Post doctorate from the Massachusetts General Hospital - Harvard Medical School, Boston, USA. Associate-Professor at USP (2003) and Member of the São Paulo State Academy of Sciences (2012) and Head of Department of Pharmacology (2013-2017). He is currently Professor of Department of Pharmacology of the Institute of Biomedical Sciences at USP (2009-). Contributed in the field of Pharmacology and Neuroscience with emphasis on aging and signalling cascade linked to degenerative diseases by introducing new knowledge in studies of adaptive responses associated with hormesis and cognition involving cardiotonic steroids, glucocorticoids, Klotho protein, glutamate and intermittent fasting and . Member of Editorial Board of Plos ONe. (Source: Lattes Curriculum)
- Aging and neuroprotection: effects of Klotho protein in energetic metabolism, Na,K-ATPase signaling and adaptative response in central nervous system, AP.TEM
Abstract
The modulation of the glutamate activity via NMDA receptor has a strong influence in the adaptive processes that prevent premature aging, as well as play an important role in cognition and degenerative processes. It is well know that the insulin signaling pathways, mediators of the inflammatory response and Na,K-ATPase acting as enzyme and as a receiver of endogenous steroids (hormones ...
- Effects of ouabain in memory and in response to stress: influence of Na, K-ATPase in the modulation of NF-kB / CREB- Wnt -BDNF glucocorticoids and / corticotropin signaling cascades in the central nervous system, AP.R
Abstract
Evidence has shown that OUA is release in a different time-course when compared to GC during a stress response. In addition, OUA also interferes with the CRH transport into the circulation indicating that this hormone plays an important role in the stress response. However, there is no data about the OUA effects during a chronic unpredictable stress. The present work aims to investigate...
- Influence of TLR2 and TLR4 receptors in behavioral and neurochemical alterations caused by intermitent fasting in knockout mice, AP.R
Abstract
Studies have shown that dietary energy restriction (DER) without malnutrition can increase resistance of neurons to excitotoxic stress and may ameliorate age-related deficits in cognitive function through hormetic mechanisms involving activation of adaptive cellular stress response pathways. Fundamental to the hormetic adaptive response is gene expression regulation. Although different ...
- Neuroinflammatory profile of rats subjected to a chronic cyclosporine treatment and possible neuroprotective action of guanosine, AP.R
Abstract
Cyclosporine (CsA) is an immunosuppressive agent frequently used in the clinic for prevention of allograft rejection and for the treatment of autoimmune diseases. Despite its desired action on the immune system, CsA treatment may present serious adverse effects. Previous resulte from our group demonstrated that chronic treatment with CsA causes endothelial damage associated with dyslipi...
(Only some records are available in English at this moment)
- The role of Klotho in Alzheimer Disease, BP.PD
Abstract
Alzheimer disease (AD) is one of the leading neurodegenerative pathologies in the western world and represents a health and socioeconomic problem. In this context , understanding the mechanisms underlying the pathogenesis of AD would be possible to identify new therapeutic options. The lost of the Endoplasmic Reticulum (ER) calcium homeostasis emerges as a central player in the developm...
- Effects of ±-Klotho protein in TNF-± signaling trought TNFR1 in glia primary culture, BP.IC
Abstract
The highest prevalence of diseases related to aging like Parkinson disease, Alzheimer disease, amyotrophic lateral sclerosis and multiple sclerosis, are a result of the increase in life expectancy. Aging is a complex and multifactorial process in which molecular, cellular and behavior alterations can be observed. Inflammation is a common and important factor between many alterations obs...
- The role of Klotho in the uptake of glutamate in astrocytic primary culture, BP.IC
Abstract
Aging is a complex and multifactorial process, associated with molecular, cellular and behavioral alterations. Oxidative stress, neuroinflammation and excitotoxicity are characteristics common to various neuropathological processes of aging as in Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer's disease. The neuronal damage by excitotoxicity occurs, ...
(Only some records are available in English at this moment)
- Improvements on the unpredictable chronic mild stress (UCMS) model for anti-depressive testing, BP.PD
Abstract
Depression is an incapacitating and hardly treated psychiatric condition so the development of new drugs has been a priority for big pharmaceutical companies and academics. New molecular entities with antagonistic action on CRHR1 and V1b receptors have been developed by Sanofi-Aventis and Pfizer and showed antidepressant activities in pre-clinical models. We investigated the effectivene...
- Modulation of Na, K-ATPase through cyclic GMP and nitric oxide pathway in central nervous system of Klotho knockout mice, BP.MS
Abstract
The Klotho protein has anti-aging function, and Klotho knockout mice (Kl-/-) showed a premature aging phenotype syndrome characterized by arteriosclerosis, osteoporosis, skin atrophy, cognitive decline and pulmonary emphysema. This syndrome can be reversed by restoring Klotho levels. Thus, the kl (-/-) is considered as a model of accelerated aging and it can provide important informatio...
- Study of the molecular effect of OUA treatment on the HPA axis of rats exposed to chronic unpredictable stress, BP.DR
Abstract
Ouabain (OUA) is a cardiotonic glycoside protein known to inhibit Na + / K +-ATPase. It is also considered an endogenous hormone and it is produced in hypothalamus and in adrenal gland, but little is known about its physiological role. However, it has been demonstrated the involvement of the OAU in the acute stress response, where physical exercise is capable of increasing its levels in...
(Only some records are available in English at this moment)
- Effects of LPS analysed in mouse models harboring disease-mutations in the 2- or ±3Na+/K+-ATPase, respectively, BE.EP.DR
Abstract
The enzyme Na+,K+-ATPase (Sodium Potassium Adenosine Trisfosfatase) is an integral membrane ion pump, essential to maintain the osmotic balance of cells, by its energy-driven ability to export Na+ and import K+. Its functions are vital to all cells. Of the four ±1-4 subunit isoforms, ±1-3 are expressed in the central nervous system. The ±2 isoform is highly enriched in atrocytes and the...
- Klotho protein and neuronal energy metabolism, BE.EP.DR
Abstract
Aging process was always investigated in C. elegans due to its reproductive cycle (they are hermaphrodites) and short lifespan (they live about 2 months). C. elegans life cycle can be indefinitely expanded once animals enter a phase known as dauer. Several genes altering this stage formation were identified and many of these genes codify proteins associated with the only tyrosine kinase...
- Ouabain as an antiapoptotic drug in neurodegenerative diseases, BE.EP.DR
Abstract
The enzyme Na,K-ATPase (Sodium Potassium Adenosine Trisfosfatase) is an integral membrane protein, highly conserved in eukaryotes, which through hydrolysis of one ATP molecule establishes the electrochemical gradient across the plasma membrane, which is essential to maintain the osmotic balance of cells, the resting membrane potential and the excitatory property of nerve and muscle cell...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 23 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 35 / 22 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 69 / 37 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 23 |
| Citations | 391 |
| Cit./Article | 17.0 |
| Data from Web of Science | |
MUNHOZ, C. D.; GARCIA-BUENO, B.; MADRIGAL, J. L. M.; LEPSCH, L. B.; SCAVONE, C.; LEZA, J. C.. Stress-induced neuroinflammation: mechanisms and new pharmacological targets. Brazilian Journal of Medical and Biological Research, v. 41, n. 12, p. 1037-1046, DEC 2008. Web of Science Citations: 108.
MUNHOZ, CAROLINA DEMARCHI; SORRELLS, SHAWN F.; CASO, JAVIER R.; SCAVONE, CRISTOFORO; SAPOLSKY, ROBERT M.. Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner. JOURNAL OF NEUROSCIENCE, v. 30, n. 41, p. 13690-13698, OCT 13 2010. Web of Science Citations: 77.
MUNHOZ‚ C.D.; GLEZER‚ I.; KAWAMOTO‚ E.M.; ARAÚJO‚ A.P.N.; LEPSCHA‚ L.B.; PLANETA‚ C.S.; DELUCIA‚ R.; SCAVONE‚ C.. Changes in sodium‚ potassium-ATPase induced by repeated fencamfamine: the roles of cyclic AMP-dependent protein kinase and the nitric oxide-cyclic GMP pathway. Neuropharmacology, v. 45, n. 8, p. 1151-1159, 2003.
GLEZER‚ I.; MUNHOZ‚ C.D.; KAWAMOTO‚ E.M.; MARCOURAKIS‚ T.; AVELLAR‚ M.C.W.; SCAVONE‚ C.. MK-801 and 7-Ni attenuate the activation of brain NF-[kappa] B induced by LPS. Neuropharmacology, v. 45, n. 8, p. 1120-1129, 2003. (02/03506-8)
ARAUJO‚ A.P.N.; DELUCIA‚ R.; SCAVONE‚ C.; PLANETA‚ C.S.. Repeated predictable or unpredictable stress: effects on cocaine-induced locomotion and cyclic AMP-dependent protein kinase activity. Behavioural Brain Research, v. 139, n. 1, p. 75-81, 2003.
KAWAMOTO, ELISA MITIKO; MUNHOZ, CAROLINA DEMARCHI; LEPSCH, LUCILIA BROCHADO; LIMA, LARISSA DE SA; GLEZER, ISAIAS; MARKUS, REGINA PEKELMANN; MARTINS DE SILVA, CLAUDIA LUCIA; CAMARINI, ROSANA; MARCOURAKIS, TANIA; SCAVONE, CRISTOFORO. Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity. NEUROBIOLOGY OF AGING, v. 29, n. 11, p. 1712-1720, NOV 2008. Web of Science Citations: 7.
NOVAES, LEONARDO S.; DOS SANTOS, NILTON BARRETO; BATALHOTE, RAFAELA F. P.; MALTA, MARILIA BRINATI; CAMARINI, ROSANA; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala. Neuropharmacology, v. 113, n. A, p. 457-466, FEB 2017. Web of Science Citations: 17. (10/13843-8, 12/24727-4, 16/03572-3)
YSHII, LIDIA M.; GEBAUER, CHRISTINA M.; PIGNOLET, BEATRICE; MAURE, EMILIE; QUERIAULT, CLEMENCE; PIERAU, MANDY; SAITO, HIROMITSU; SUZUKI, NOBORU; BRUNNER-WEINZIERL, MONIKA; BAUER, JAN; et al. CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model. BRAIN, v. 139, n. 11, p. 2923-2934, NOV 2016. Web of Science Citations: 12. (13/22196-4)
CARARO-LOPES, MARINA MINTO; YOKOYAMA MAZUCANTI, CAIO HENRIQUE; SCAVONE, CRISTOFORO; KAWAMOTO, ELISA MITIKO; BERWICK, DANIEL CHARLES. The relevance of alpha-KLOTHO to the central nervous system: Some key questions. AGEING RESEARCH REVIEWS, v. 36, p. 137-148, JUL 2017. Web of Science Citations: 10. (13/10787-8, 14/14199-6, 11/21308-8, 16/07427-8)
CABRAL-COSTA, J. V.; ANDREOTTI, D. Z.; MELLO, N. P.; SCAVONE, C.; CAMANDOLA, S.; KAWAMOTO, E. M.. Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice. SCIENTIFIC REPORTS, v. 8, JUN 5 2018. Web of Science Citations: 0. (16/22996-9, 13/20594-2, 15/25491-2, 11/21308-8, 14/18689-8)
KINOSHITA, PAULA F.; YSHII, LIDIA M.; ORELLANA, ANA MARIA M.; PAIXAO, AMANDA G.; VASCONCELOS, ANDREA R.; LIMA, LARISSA DE SA; KAWAMOTO, ELISA M.; SCAVONE, CRISTOFORO. Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells. SCIENTIFIC REPORTS, v. 7, JUL 7 2017. Web of Science Citations: 2. (11/04327-9, 14/05026-0, 16/07376-4, 11/22844-0, 11/21308-8, 11/10303-5, 11/12255-8)
DE MOLLO, NATALIA PRUDENTE; ORELLANA, ANA MARIA; MAZUCANTI, CAIO HENRIQUE; LIMA, GEOVANNI DE MORALS; SCAVONE, CRISTOFORO; KAWAMOTO, ELISE MITIKO. Insulin and Autophagy in Neurodegeneration. FRONTIERS IN NEUROSCIENCE, v. 13, MAY 22 2019. Web of Science Citations: 0. (16/22996-9, 16/07427-8)
KAWAMOTO, E. M.; LIMA, L. S.; MUNHOZ, C. D.; YSHII, L. M.; KINOSHITA, P. F.; AMARAL, F. G.; PESTANA, R. R. F.; ORELLANA, A. M. M.; CIPOLLA-NETO, J.; BRITTO, L. R. G.; et al. Influence of N-methyl-D-aspartate receptors on ouabain activation of nuclear factor-kappa B in the rat hippocampus. Journal of Neuroscience Research, v. 90, n. 1, p. 213-228, JAN 2012. Web of Science Citations: 23.
ORELLANA, ANA MARIA; LEITE, JACQUELINE ALVES; KINOSHITA, PAULA FERNANDA; VASCONCELOS, ANDREA RODRIGUES; ANDREOTTA, DIANA ZUKAS; LIMA, LARISSA DE SA; XAVIER, GILBERTO FERNANDO; KAWAMOTO, ELISA MITIKO; SCAVONE, CRISTOFORO. Ouabain increases neuronal branching in hippocampus and improves spatial memory. Neuropharmacology, v. 140, p. 260-274, SEP 15 2018. Web of Science Citations: 0. (16/07427-8, 11/22844-0)
NOVAES, LEONARDO SANTANA; DOS SANTOS, NILTON BARRETO; DRAGUNAS, GUILHERME; PERFETTO, JULIANO GENARO; CARLOS LEZA, JUAN; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats. Neuroscience, v. 393, p. 273-283, NOV 21 2018. Web of Science Citations: 3. (10/13843-8, 12/24727-4, 16/03572-3, 12/24002-0)
CRUNFLI, FERNANDA; MAZUCANTI, CAIO HENRIQUE; MACEDO DE MORAES, RUAN CARLOS; COSTA, ANDRESSA PEREIRA; RODRIGUES, ALICE CRISTINA; SCAVONE, CRISTOFORO; TORRAO, ANDREA DA SILVA. NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance. JOURNAL OF ALZHEIMER'S DISEASE, v. 65, n. 4, p. 1427-1443, 2018. Web of Science Citations: 1. (14/06372-0, 10/14090-3, 16/07427-8)
VASCONCELOS, ANDREA RODRIGUES; DOS SANTOS, NILTON BARRETO; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders. FRONTIERS IN PHARMACOLOGY, v. 10, FEB 4 2019. Web of Science Citations: 0. (12/24727-4, 16/07427-8)
RAVELLI, KATHERINE GARCIA; RAMOS, ADRIANA DE TOLEDO; GONCALVES, LUANA BARACHO; MAGNOLI, FABIO CARLOS; PAOLO TRONCONE, LANFRANCO RANIERI. Phoneutria nigriventer spider toxin Tx2-6 induces priapism in mice even after cavernosal denervation. Toxicon, v. 130, p. 29-34, MAY 2017. Web of Science Citations: 1. (15/08098-5)
LEPSCH, LUCILIA B.; PLANETA, CLEOPATRA S.; SCAVONE, CRITOFORO. Cocaine Causes Apoptotic Death in Rat Mesencephalon and Striatum Primary Cultures. BIOMED RESEARCH INTERNATIONAL, 2015. Web of Science Citations: 10.
RAMOS, ADRIANA T.; TUFIK, SERGIO; TRONCONE, LANFRANCO R. P.. Control of Stress-Induced ACTH Secretion by Vasopressin and CRH: Additional Evidence. NEUROPSYCHOBIOLOGY, v. 73, n. 3, p. 184-190, 2016. Web of Science Citations: 2. (98/14303-3, 13/18897-7, 15/08098-5)
KAWAMOTO, E. M.; GLEICHMANN, M.; YSHII, L. M.; DE SA LIMA, L.; MATTSON, M. P.; SCAVONE, C.. Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. Brazilian Journal of Medical and Biological Research, v. 45, n. 1, p. 58-67, JAN 2012. Web of Science Citations: 12. (06/59722-1)
DEGASPARI, SABRINA; TZANNO-MARTINS, CARMEN BRANCO; FUJIHARA, CLARICE KAZUE; ZATZ, ROBERTO; BRANCO-MARTINS, JOAO PAULO; VIEL, TANIA ARAUJO; BUCK, HUDSON DE SOUZA; MARQUES ORELLANA, ANA MARIA; BOEHMER, ANA ELISA; LIMA, LARISSA DE SA; et al. Altered KLOTHO and NF-kappa B-TNF-alpha Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats. PLoS One, v. 10, n. 5, MAY 11 2015. Web of Science Citations: 21.
VASCONCELOS, ANDREA RODRIGUES; KINOSHITA, PAULA FERNANDA; YSHII, LIDIA MITIKO; MARQUES ORELLANA, ANA MARIA; BOEHMER, ANA ELISA; LIMA, LARISSA DE SA; ALVES, ROSANA; ANDREOTTI, DIANA ZUKAS; MARCOURAKIS, TANIA; SCAVONE, CRISTOFORO; et al. Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus. NEUROBIOLOGY OF AGING, v. 36, n. 5, p. 1914-1923, MAY 2015. Web of Science Citations: 12. (11/10303-5)
YSHII, LIDIA; GEBAUER, CHRISTINA; BERNARD-VALNET, RAPHAEL; LIBLAU, ROLAND. Neurons and Tcells: Understanding this interaction for inflammatory neurological diseases. European Journal of Immunology, v. 45, n. 10, p. 2712-2720, OCT 2015. Web of Science Citations: 11. (13/22196-4)
YSHII, LIDIA M.; DENADAI-SOUZA, ALEXANDRE; VASCONCELOS, ANDREA R.; AVELLAR, MARIA CHRISTINA W.; SCAVONE, CRISTOFORO. Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells. JOURNAL OF NEUROINFLAMMATION, v. 12, OCT 26 2015. Web of Science Citations: 5. (09/12375-3, 11/12255-8, 11/10303-5)
VASCONCELOS, ANDREA R.; YSHII, LIDIA M.; VIEL, TANIA A.; BUCK, HUDSON S.; MATTSON, MARK P.; SCAVONE, CRISTOFORO; KAWAMOTO, ELISA M.. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment. JOURNAL OF NEUROINFLAMMATION, v. 11, MAY 6 2014. Web of Science Citations: 57. (09/11915-4, 06/57729-9)