Graduate at Farmácia e Bioquímica from Universidade Estadual Paulista Júlio de Mesquita Filho (1998), master's at General Biology from Universidade Estadual Paulista Júlio de Mesquita Filho (2001) and ph.d. at Fisiologia Humana from Universidade de São Paulo (2007). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: eIF5A. (Source: Lattes Curriculum)
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The amino acid hypusine was first identified in 1971 from bovine brain extract. Later, this amino acid was found in liver, kidney, muscle and blood of other mammals. In addition, hypusine is a substrate to synthesise the ±-(³-aminobutyryl)-hypusine (GABA-hypusine) dipeptide. The GABA is the most representative inhibitory neurotransmitter of the central nervous system. It is noted that the…
The eukaryotic translation initiation factor 5A (eIF5A) protein is highly conserved, been produced by archaea and eukaryotes. This factor possesses a particular amino acid residue named hypusine that is not found in others proteins. The hypusine is essential for its activity and is formed by a post translational modification, using spermidine as substrate, called hypusination. The eIF5A p…
(Only some records are available in English at this moment)
The use of macrophyte type aquatic plants for phytoremediation of environmental contaminants represents a platform with great potential for removal of eutrophic compounds, nitrogen (N) and phosphorus (P), as well as other pollutants. In this context, phytoremediation can efficiently reduce environmental contaminants, and the aquatic plant behaves as a photosynthetic pump capable of adsorb…
The Leukocyte Secretory Protease Inhibitor (SLPI) is a non-glycosylated cationic protein with action against serine protease, serving to control the excessive release of secreted proteases such as trypsin, chymotrypsin, elastase and cathepsin G from mammal. In addition to its antiprotease activity, SLPI has been shown to express antibacterial, antiviral, antifungal and anti-inflammatory p…
The amino acid hypusine was first described in 1971, from bovine brain. Later, the hypusine was found in other mammalian tissues, like liver, kidney, muscle, and blood. In addition to being found in its free form, the hypusine is an amino acid residue present in eukaryotic translation initiation factor 5A (eIF5A). The eIF5A is the unique protein described that contains hypusine, produced …
The eukaryotic translation initiation factor 5A (EIF5A) protein is highly conserved in eukaryotes. Some studies have showed that EIF5A has important roles in cell proliferation control and HIV-1 replication. EIF5A possesses a particular amino acid residue named hypusine that is not found in others proteins. The hypusine is essential for its activity and is produced by a post-translational…
(Only some records are available in English at this moment)
The amino acid hypusine was first identified in 1971 from bovine brain extract. Later, this amino acid was found in the liver, kidney, muscle, and blood of other mammals. Hypusine is formed from a post-translational modification that occurs at the eukaryotic translation initiation factor 5A (eIF5A) and the free form results from the degradation of this protein. The eIF5A protein is the on…
Algae are a promising platform for producing a broad range of bio-products including recombinant proteins for animal feed supplements or pharmaceutical applications. Scalable and low-cost production platforms are of growing importance for the development of affordable recombinant proteins, especially proteins that require large dosing regimens and/or have large patient populations. Curren…
The eukaryotic translation initiation factor 5A (eIF5A) is highly conserved in archaea and eukaryotes, and is the only protein containing the amino acid residue hypusine, which is required for its activity. eIF5A has been involved in different points of the gene expression control, such as transcription, nuclear pore transport, nonsense-mediated decay (NMD), and translation. In addition, …
| 4 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 11 / 7 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 19 / 15 | All research grants and scholarships |
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CV Lattes
ORCID