Guilherme Giannini Artioli

• Abstract

  Carnosine (ß-alanyl-L-histidine) is a dipeptide abundantly found in skeletal and cardiac muscles as well as in excitable tissues, although the physiological roles played by carnosine and its methylated analogues are still poorly understood. Evidence indicates that carnosine acts as a physico-chemical buffer during intense efforts, which is corroborated by the performance improvements obse…

  Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism, AP.JP

• Abstract

  Carnosine is a cytoplasmic dipeptide found in high concentrations in the skeletal muscle of both vertebrates and non-vertebrates, and is associated with muscle buffering, sensitivity of calcium release channels and/or calcium sensitivity of the contractile apparatus and scavenging of reactive oxygen species. It has been shown that the elevation of muscle carnosine concentrations through t…

  Carnosine metabolism in skeletal muscle: a multi-approach study, AP.TEM

• Abstract

  Based on the potential of HMB supplementation to optimize strength and muscle mass gains from strength training, which may have important applications in the context of sport and health, and based on uncertainties regarding the pharmacological form with better bioavailability, This research project aims to analyze the bioavailability, absorption kinetics and clearance of blood HMB, as wel…

  Evaluation of bioavailability and absorption kinetics of different forms of B-hydroxy-B-methylbutyrate (HMB), BP.IC

• Abstract

  Increasing and maintaining muscle mass has been of great interest to many populations, which can be achieved through strength training and potentiated through dietary strategies such as increased/adequate protein intake and supplement intake. Phosphatidic Acid (PA) is a lipid messenger that has been shown to increase muscle protein synthesis due to stimulation of PI3K/AKT/mTOR signaling. …

  Effects of phosphatidic acid supplementation on muscular force and hypertrophy in response to strenght training, BP.IC

• Abstract

  Muscle strength is an important capacity for health and sports performance. It is well known that strength training (ST) is an important way to improve muscle strength and promote hypertrophy. Recent studies show that responses to ST are highly variable between subjects, as participants of similar characteristics undergoing the same training regimen display remarkably variability in stren…

  Polygenic profile associated to response to strength training, BP.IC

(Only some records are available in English at this moment)