graduate at Medicina from Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (1981) and ph.d. at Phd Of Philosophy Em Farmacologia from University of London (1986). Has experience in Pharmacology, focusing on Clinical Farmacology, acting on the following subjects: nitric oxide, bioavailability, bradykinin, edrf and endothelin-1. (Source: Lattes Curriculum)
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The endothelium is an organ capable of regulating vascular tone through the release of endothelium-derived relaxing factors such as nitric oxide, prostacyclin, etc., or endothelium-derived contracting factors as endothelins, prostanoid. In addition, the current physiological concept poses that such regulation can also occur through the release of exclusively neural-derived catecholamines.…
The endothelium is an organ capable of regulating vascular tone through the release of endothelium-derived relaxing factors (nitric oxide and prostacyclin - PGI2) and endothelium-derived contracting factors (endothelin - ET1 and prostanoid - PGH2). In addition, the current physiological concept poses that such regulation can also occur through the release of exclusively neural-derived cat…
Reptiles are the first amniotes to develop an intromitent penis, however until now the mechanisms involved in the electrical field stimulation-induced contraction on corpora cavernosa isolated from Crotalus durissus terrificus were not investigated. Crotalus and rabbit corpora cavernosa were mounted in 10 mL organ baths for isometric tension recording. Electrical field stimulation (EFS)-i…
For several years we have been designing, developing and testing novel NSAIDs for treatment of diseases such as osteoarthritis and rheumatoid arthritis. Linking an H2S-releasing moiety to an NSAID, in the majority of cases, yields a drug with comparable anti-inflammatory potency to the 'parent' NSAID, but one which produces substantially less damage and bleeding in the stomach and small i…
(Only some records are available in English at this moment)
Endothelial cells modulate vascular reactivity through the release of mediators such as nitric oxide and endothelin. The current dogma is that catecholamines modulate vascular tonus, cardiac chronotropism and inotropism through their release from adrenergic terminals, and with action on a and b adrenergic receptors. Using mass spectrometry, we identified basal release of endothelium-depen…
Introduction: It is well established that endothelial cells modulate vascular reactivity through the release of mediators such as prostacyclin (Moncada et al., 1976), nitric oxide (Furchgott and Zawadzki, 1980) and endothelin (Yanagisawa et al., 1988). Catecholamines modulate vascular tone through actions on ±- and ²-adrenergics (Ahlquist, 1948); meanwhile, the production and release of c…
6-nitrocatecholamines are a class of nitrated catecholamine-derived molecules, which includes 6-nitrodopamine, 6-nitroadrenaline and 6-nitronadrenaline. Current evidence indicates that those molecules are endogenously synthesized and constitute important modulators of cell signaling in different tissues. Vas deferens is one of those tissues whose function is potentialy modulated by 6-nitr…
(Only some records are available in English at this moment)
Electric field stimulation (EFS) is a technique in which an electrical stimulus is applied uniformly to isolated tissue in short-wave pulses. Depending on the mediators released by the EFS, tissue contraction or relaxation may occur. Initially, our research group demonstrated that stimulated contractions of human umbilical cord vessels (HUCV) depend on the presence of the endothelium and …
In electric field stimulation (EFS) an electrical stimulus is applied uniformly to an isolated tissue in short-wave pulses. Depending on the mediators released by the EFS, tissue contraction or relaxation may occur. Initially, our research group demonstrated that the stimulated contractions of human umbilical cord vessels (HUCV) depend on the presence of the endothelium and are not affect…
In developing/underdeveloped countries, or in places where natural disasters or armed conflicts occur, high rates of mortality are observed related to complications in cases of diarrhea, leading to the death of about 2 and a half million children every year, mainly caused by the infection with enterotoxigenic strains of Escherichia coli. The recommended treatments involve: (1) oral hydrat…
(Only some records are available in English at this moment)
In therapy with immunosuppressant drugs, therapeutic drug monitoring (TDM) is essential to treatment success. Therefore, analytical methods with higher precision, accuracy, sensitivity, selectivity and speed are demanding. This project aims to develop an improved sample-preparation protocol for simultaneous quantification of sirolimus, everolimus, tacrolimus and ciclosporin in whole blood…
The phosphorylation of endothelial nitric oxide (NO) synthase (eNOS) on Tyr81 was shown to increase NO production and blood vessel relaxation in response to agonist stimulation. Although Src has been initially reported to phosphorylate this tyrosine residue, the regulation of the phosphorylation of this site remains largely unexplored. Preliminary work at the Institute for Vascular Signal…
Aspirin, often together with a P2Y12 receptor blocker, is used as anti-thrombotic protection for patients at risk of heart attacks and strokes. However, despite these drugs many patients still have an elevated risk of thrombosis. Aspirin and the most widely used P2Y12 receptor blockers are pharmacokinetically short-lived but permanently inhibit circulating platelets. In healthy individual…
| 1 / 1 | Ongoing research grants |
| 34 / 22 | Completed research grants |
| 11 / 11 | Ongoing scholarships in Brazil |
| 69 / 20 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 118 / 57 | All research grants and scholarships |
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CV Lattes
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