Bachelor of Biological Sciences Medical Modality from Escola Paulista de Medicina (1979), he did a master's and doctorate in Microbiology and Immunology from Escola Paulista de Medicina (1983 and 1988, respectively), with part of the work having been conducted at New York University Medical School ( 1982) and the Center for Vaccine Development (Baltimore, USA) (1986). She was a Postgraduate Adjunct Coordinator at the Dean of Postgraduate Studies and Research at the Federal University of São Paulo (03/2013-04/2017). She was Head of the Discipline of Microbiology at UNIFESP (and a member of the Postgraduate Committee of the Postgraduate Program in Microbiology and Immunology at UNIFESP. She is currently a Full Professor at the Federal University of São Paulo. She is also a member of the Committee on Boards and the Commission for Accreditation and Re-accreditation of the Graduate and Research Chamber of the Escola Paulista de Medicina, UNIFESP. She is Associate Editor of the Brazilian Journal of Microbiology, a scientific journal edited by the Brazilian Society of Microbiology; she is the Review Editor of Frontiers in Cellular in Infection Microbiology. She is a reviewer for several national and international journals. Member of the Advisory Committee on Microbiology and Parasitology CNPq (07/2022 to 06/2025). She has experience in Microbiology, with emphasis on genetic diversity, bacterial pathogenicity, and epidemiology, acting mainly on the following topics: adherence, invasion, diarrhea, and urinary tract infection. Escherichia coli enteropathogenic, enteroaggregative E. coli, uropathogenic E.coli, and Escherichia albertii. (Source: Lattes Curriculum)
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Classically, pathogenic strains of Escherichia coli were thought to cause intestinal infections (II) or extraintestinal infections (IEI). However, several recent reports have demonstrated the occurrence of E. coli strains causing II and IEI in the same patient. Typical enteroaggregative E. coli (EAEC), one of the intestinal pathogenic E. coli pathotypes, is characterized by harboring a v…
Escherichia coli are characterized by harboring both commensal and / or symbiotic strains, as well as strains that are pathogenic to the intestinal and extraintestinal sites of humans and warm-blooded animals. This plurality of behavior is due, on the one hand, to the fact that most of its virulence determinants are encoded in mobile genetic elements and, on the other hand, the extreme pe…
Some adapted clones of Escherichia coli carry genes that encode properties that allow them to colonize different host sites, favoring the establishment of intestinal or extraintestinal infections. Intestinal infections are caused by different diarrheogenic E. coli (DEC) pathotypes, while the extraintestinal infections are caused by strains of extraintestinal pathogenic E. coli (ExPEC). Ex…
Enteropathogenic Escherichia coli (EPEC) produce characteristic intestinal lesions (attaching/effacing lesions, A/E), being identified by the production of the localized adherence (LA+) pattern in HeLa cells. LA+ EPEC strains of the O119:H6 serotype constituted, for many decades, one of the most frequent childhood diarrheal agents in our environment. Curiously, we have identified O119:H6 …
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Infection of the intestinal epithelium by certain enteropathogens results in a modification in the expression of genes encoding pro-inflammatory cytokines and the production of mucins. Our group demonstrated that some strains of atypical enteropathogenic Escherichia coli (aEPEC) significantly increase mucus production when inoculated into ligated rabbit ileal loops in vivo. In the same st…
Escherichia coli is a globally distributed bacterium that colonizes the gut. E. coli strains can be divided into three groups: commensals, which are harmless to the host; diarrheagenic (diarrheagenic E. coli-DEC), which cause intestinal diseases; and those which cause extraintestinal infections (extraintestinal pathogenic E. coli-ExPEC). ExPEC strains are classified according to the site …
Some Escherichia coli strains present virulence factors that contribute to colonization, invasion and, consequently, the establishment of disease in different parts of the human body. E. coli strains capable of causing intestinal infections are called diarrheagenic E. coli (DEC) while those that cause extraintestinal infections are named extraintestinal pathogenic E. coli (ExPEC). The lat…
Escherichia coli is a gram-negative bacillus that can be classified into commensal strains and disease-causing strains. Diarrheogenic E. coli (DEC) are classified in five distinct pathotypes. One of these pathotypes, denominated enteropathogenic E. coli (EPEC), has two subdivisions, which are based on the presence (typical EPEC) or absence (atypical EPEC) of the EAF (EPEC adherence factor…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 21 / 11 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 21 / 9 | Completed scholarships in Brazil |
| 45 / 23 | All research grants and scholarships |
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