CV Lattes
Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Farmácia e Bioquímica from Universidade de São Paulo (1970) and doctorate at Farmacologia from Instituto de Ciências BiomédicasUniversidade de São Paulo (1979). Has experience in Medicine, acting on the following subjects: diabetes mellitus, insulina, microcirculação mesentérica, inflamação and microscopia intra-vital. (Source: Lattes Curriculum)
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A functional microvascular system is essential for adequate tissue oxygenation, particularly in solid organs used for transplantation. Recent studies have shown that microvascular damage seems to be an important cause of early and long-term lung graft failure. Experimental evidence indicates that brain death triggers a persistent mesenteric hypoperfusion, endothelial activation and leukoc…
Tissue ischaemia determines a set of metabolic changes that may lead to cellular death. Although essential to prevent tissue damage, the restoration of blood flow itself may aggravate ischaemic injury, phenomenon which is entitled ischemia/reperfusion injury. Regarding aortic reconstructive surgery, the supraceliac aortic occlusion may compromise the blood flow of either the organs close …
It has been previously shown that brain death itself induces hypoperfusion at mesenteric microcirculation associated to a pronounced reduction in endogenous corticosterone levels leading to increased local inflammation and organ dysfunction in a rat model of brain death. These events occur paradoxically associated with induced leucopenia after brain damage. This study aims to investigate …
(Only some records are available in English at this moment)
The integrity of the microcirculation is essential for adequate tissue oxygenation, particularly after organ transplantation. Experimental evidence indicates that brain death determines microcirculatory alterations, including mesenteric hypoperfusion, endothelial activation and leukocyte migration associated with reduced serum concentrations of endogenous corticosterone. Hormonal changes …
Elder and immunossupressed patients exposed to trauma and hemorrhage are more prone to develop sepsis, septic shock, and systemic inflammatory response syndrome. Early goal directed therapy is critical for tissue perfusion associated to systemic microcirculatory dysfunction. Experimental evidences show that small volumes of hypertonic saline solution (7.5%) induce blood volume expansion, …
Clinical studies in patients with chronic obstructive pulmonary disease (COPD) showed that structural and functional alterations of the lung microcirculation are major factors for the development of pulmonary hypertension and right ventricular hypertrophy during COPD-associated hypoxemia. In addition, pulmonary microcirculatory dysfunctions associated with diabetes mellitus increase the g…
| 12 / 7 | Completed research grants |
| 15 / 3 | Completed scholarships in Brazil |
| 27 / 10 | All research grants and scholarships |
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