graduate at História Natural from Universidade Estadual Paulista Júlio de Mesquita Filho (1968) and ph.d. at Physiology from Universidade Estadual de Campinas (1973). Has experience in Physiology, focusing on Physiology of Organs ans Systems, acting on the following subjects: secreção de insulina, ilhotas de langerhans, insulin secretion, prolactina and glicose. (Source: Lattes Curriculum)
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Diabetes Mellitus is a chronic metabolic syndrome that affects hundreds of millions of people, and is the direct cause of death for over a million people every year. Severe chronic complications associated to it are the main cause of blindness and visual dysfunctions, limb amputation, kidney failure, neuropathies, and cardiovascular diseases. Maintaining glicemic homeostasis is crucial to…
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
Diabetes mellitus (DM) is a syndrome that affects 380 million people in the world. This syndrome may cause chronic and severe health problems, increasing morbidity and mortality. Among these complications, visual defects and blindness, limb amputation, renal failure, neuropathies and cardiovascular diseases are the most frequent. The two most important forms of diabetes are DM1 (10 - 15%)…
Diabetes Mellitus (DM1 or DM2) is defined as a syndrome of chronic hyperglycemia due to the lack of insulin production that results from the reduction of beta cell mass which, in turn, originated from an increase in cell apoptosis and/or deficient beta cell regeneration. In DM2, reduction of beta cell mass is frequently accompanied by an increase in insulin resistance in muscle, adipose, …
This proposal has the following objectives: 1) study of the mechanisms of pancreatic beta cell destruction during the early phases of type 2 diabetes (the search for strategies to inhibit that process, as well as to recover the cell mass in different animal models); 2) morphofunctional characterization of the pancreatic islets of mice submitted to protein restriction or to a high-lipid di…
(Only some records are available in English at this moment)
The aggregation of amylin or IAPP (Islet Amyloid Polypeptide) in insoluble polymeric protein fibers (or pancreatic amyloid) is among the factors leading to loss of pancreatic beta cell mass observed in Diabetes Mellitus type 2 (DM2). The IDE (Insulin Degrading Enzyme) is the main enzyme responsible for the degradation of IAPP and studies have shown that the expression of the IDE can be mo…
Resistance exercise presents beneficial effects upon glycemic control in diabetic patients. However, most researchers investigate the link between these effects and the adaptations in skeletal muscle. Whereas the effects of resistance exercise on pancreatic beta-cell function remains unclear. Thus, the present study intent to investigate the effects of resistance exercise training upon pa…
Resistance exercise training helps to control the glycemia in type-1 diabetic (T1-D) patients. However, mostly of studies on this matter, focuses on the involvement of skeletal muscle in this context. Whereas the impact of resistance exercises training upon pancreatic beta cell of diabetic animals was neglected. Here, we aim to verify if resistance exercise training promotes positive effe…
(Only some records are available in English at this moment)
The pancreatic beta-cell dysfunction plays an important role on the development of type 2diabetes (DM2), and it is know that genetic and epigenetic factors contribute to the susceptibility of this disease. Epidemiological evidences suggest that exposure to an adverse environment, in early life, is associated with an increased risk of metabolic disorders in adulthood. Overexposure to gluco…
The pancreatic delta cell is the third more abundant cell in pancreatic islet, and inhibits, in a paracrine-fashion, through somatostatin, both insulin and glucagon secretion and, consequently, modulate glucose homeostasis. Recently, it was shown that somatostatin secretion is stimulated by UCN3, which is secreted together with insulin by beta cell. In a preliminary study, we observed tha…
Pancreatic beta cell failure is crucial to type 2 diabetes (T2-D) developments. The insulin resistance in the peripheral tissues is usually linked to this phenomenon. However, most of insulin-resistant obese people do not develop T2-D. It indicates an important role of genetic susceptibility in this context. Nevertheless, less than 10% of genetic variants are associated to the disease. In…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 13 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 48 / 20 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 72 / 38 | All research grants and scholarships |
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CV Lattes
ORCID