Pedro Augusto Carlos Magno Fernandes
CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Assistant professor of the Department of Physiology of the Institute of Biosciences of the University of São Paulo since 2010. PhD in Sciences (General Physiology) by the Department of Physiology of the Institute of Biosciences of the University of São Paulo (2009). Bachelor in Biological Sciences by the Institute of Biosciences of the University of São Paulo (2003). Has experience in the areas of General Physiology, Pharmacology, Systems Biology and Immunology. The current research emphasis is on the characterization of neuroimmunoendocrine mechanisms associated with the development of inflammatory processes and tumors. (Source: Lattes Curriculum)
- Evaluation of the therapeutic potential of modulating the of immune-pineal axis in an animal model of lethal systemic inflammation, AP.R
Abstract
In the mounting phase of inflammatory responses, the activation of the immune pineal axis facilitates leukocyte migration to peripheral tissues by inhibiting the production of melatonin by the pineal gland, and locally modulates the immune response due to the production of melatonin by peripheral immunocompetent cells and by glial cells of the central nervous system. Restoring the produ...
- Characterization of the role of adrenal/pineal interaction in the immune-pineal axis context, AP.R
Abstract
The immune-pineal axis predicts, in one hand, that the melatonin produced by the pineal gland controls, in a time dependent manner, the immune response of tissues in the periphery of the body and, in the other hand, inflammatory modulators, such as cytokines and glucocorticoids, modulate the nocturnal pineal melatonin production. Glucocorticoids exert a dual effect on the pineal functio...
- Characterization of the melatonergic system of human gliomas and its implication on tumor aggressiveness and invasiveness, BP.DD
Abstract
Gliomas, the most frequent primary brain tumor in adults, are classified into four (I-IV) histological grades. Gliomas grade IV, known as glioblastomas, are highly aggressive tumors associated with a median survival of only 15 months. In vitro studies have shown that high concentrations of melatonin, a hormone synthesized mainly by the pineal gland, significantly reduce the migration an...
- Comparison of activation of the pineal-immune axis between lethal and non-lethal systemic inflammatory processes, BP.IC
Abstract
The melatonin produced by the pineal gland during the dark stage of the environment controls the endogenous oscillatory system of mammals, adjusting the activity of various organs, tissues and cells. Nocturnal melatonin decreases, for example, the expression of vascular endothelial adhesion molecules by reducing the migration of immunocompetent cells between the circulation and tissues....
- Role of melatonine on proliferation and cellular migration in line of human medulloblastoma, BP.IC
Abstract
Medulloblastoma is the most common tumor in children, and to be highly aggressive and invasive, is classified as grade IV by the World Health Organization and responsible for a large proportion of infant mortality from tumors. Conventional therapies for treatment are responsible for damaging the brain tissue in children's development and often cause sequelae. Studies have reported a gre...
- Determination of the effects of interleukin-10 on the biosynthetic pathway of melatonin of cultured rat pineal glands, BP.IC
Abstract
The pineal gland is a neuroendocrine organ that transduces the photic environmental information to the rest of the body through the nocturnal production of melatonin. Our group and others have been demonstrating that, besides the chronobiological effects, the pineal gland is also actively involved in the mounting and in the resolution of an inflammatory response. In the context of this ...
(Only some records are available in English at this moment)
- The role of tumor microenvironment elements in malignant cell plasticity and heterogeneity, BE.EP.DD
Abstract
Cellular plasticity and heterogeneity are fundamental features of human tumors and arise as a consequence of genetic and epigenetic mechanisms, as well as environmental signals. Such diversity is considered an important source of treatment failure, as subpopulations of drug-resistant cells may underlie tumor recurrence and metastasis. In the tumor ecosystem, malignant and stromal cells ...
*Updated May 18, 2019
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 11 / 8 | All Research Grants and Scholarships |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 5 |
| Citations | 27 |
| Cit./Article | 5.4 |
| Data from Web of Science | |
FERNANDES, PEDRO A.; TAMURA, EDUARDO K.; D'ARGENIO-GARCIA, LETICIA; MUXEL, SANDRA M.; CRUZ-MACHADO, SANSERAY DA SILVEIRA; MARCOLA, MARINA; CARVALHO-SOUSA, CLAUDIA E.; CECON, ERIKA; FERREIRA, ZULMA S.; MARKUS, REGINA P.. Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis. Neuroendocrinology, v. 104, n. 2, p. 126-134, 2017. Web of Science Citations: 9. (10/52687-1, 13/13691-1)
KINKER, GABRIELA S.; OBA-SHINJO, SUELI M.; CARVALHO-SOUSA, CLAUDIA E.; MUXEL, SANDRA M.; MARIE, SUELY K. N.; MARKUS, REGINA P.; FERNANDES, PEDRO A.. Melatonergic system-based two-gene index is prognostic in human gliomas. Journal of Pineal Research, v. 60, n. 1, p. 84-94, JAN 2016. Web of Science Citations: 7. (10/52687-1, 13/13691-1)
KINKER, GABRIELA SARTI; THOMAS, ANDREW MALTEZ; CARVALHO, VINICIUS JARDIM; LIMA, FELIPE PRATA; FUJITA, ANDRE. Deletion and low expression of NFKBIA are associated with poor prognosis in lower-grade glioma patients. SCIENTIFIC REPORTS, v. 6, APR 7 2016. Web of Science Citations: 3. (15/01507-7, 14/27287-0, 13/03447-6, 15/01587-0, 14/09576-5)
MONTEIRO DE ASSIS, LEONARDO VINICIUS; KINKER, GABRIELA SARTI; MORAES, MARIA NATHALIA; MARKUS, REGINA P.; FERNANDES, PEDRO AUGUSTO; DE LAURO CASTRUCCI, ANA MARIA. Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma. FRONTIERS IN ONCOLOGY, v. 8, JUN 12 2018. Web of Science Citations: 1. (14/27287-0, 13/24337-4, 14/16412-9, 12/50214-4)
MARKUS, REGINA P.; FERNANDES, PEDRO A.; KINKER, GABRIELA S.; CRUZ-MACHADO, SANSERAY DA SILVEIRA; MARCOLA, MARINA. Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. British Journal of Pharmacology, v. 175, n. 16, SI, p. 3239-3250, AUG 2018. Web of Science Citations: 7. (10/52687-1, 13/13691-1, 15/04557-5, 14/27287-0)