Assistant professor of the Department of Physiology of the Institute of Biosciences of the University of São Paulo since 2010. PhD in Sciences (General Physiology) by the Department of Physiology of the Institute of Biosciences of the University of São Paulo (2009). Bachelor in Biological Sciences by the Institute of Biosciences of the University of São Paulo (2003). Has experience in the areas of General Physiology, Pharmacology, Systems Biology and Immunology. The current research emphasis is on the characterization of neuroimmunoendocrine mechanisms associated with the development of inflammatory processes and tumors. (Source: Lattes Curriculum)
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Changes in the Bone Marrow (BM) microenvironment, via inadequate production of immune/hormonal mediators and dysregulated interactions between hematopoietic and mesenchymal cells, are associated with the development of Acute Myeloid Leukemia (AML). Medullary TNF induces the local production of melatonin, which regulates self-renewal and retention of hematopoietic stem cells in BM. Althoug…
In the mounting phase of inflammatory responses, the activation of the immune pineal axis facilitates leukocyte migration to peripheral tissues by inhibiting the production of melatonin by the pineal gland, and locally modulates the immune response due to the production of melatonin by peripheral immunocompetent cells and by glial cells of the central nervous system. Restoring the product…
The immune-pineal axis predicts, in one hand, that the melatonin produced by the pineal gland controls, in a time dependent manner, the immune response of tissues in the periphery of the body and, in the other hand, inflammatory modulators, such as cytokines and glucocorticoids, modulate the nocturnal pineal melatonin production. Glucocorticoids exert a dual effect on the pineal function,…
The melatonin produced by the pineal gland during the dark stage of the environment controls the endogenous oscillatory system of mammals, adjusting the activity of various organs, tissues and cells. Nocturnal melatonin decreases, for example, the expression of vascular endothelial adhesion molecules by reducing the migration of immunocompetent cells between the circulation and tissues. D…
Gliomas, the most frequent primary brain tumor in adults, are classified into four (I-IV) histological grades. Gliomas grade IV, known as glioblastomas, are highly aggressive tumors associated with a median survival of only 15 months. In vitro studies have shown that high concentrations of melatonin, a hormone synthesized mainly by the pineal gland, significantly reduce the migration and …
Medulloblastoma is the most common tumor in children, and to be highly aggressive and invasive, is classified as grade IV by the World Health Organization and responsible for a large proportion of infant mortality from tumors. Conventional therapies for treatment are responsible for damaging the brain tissue in children's development and often cause sequelae. Studies have reported a great…
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Cellular plasticity and heterogeneity are fundamental features of human tumors and arise as a consequence of genetic and epigenetic mechanisms, as well as environmental signals. Such diversity is considered an important source of treatment failure, as subpopulations of drug-resistant cells may underlie tumor recurrence and metastasis. In the tumor ecosystem, malignant and stromal cells co…
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 8 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 9 | All research grants and scholarships |
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CV Lattes
ORCID