Abstract
Changes in the Bone Marrow (BM) microenvironment, via inadequate production of immune/hormonal mediators and dysregulated interactions between hematopoietic and mesenchymal cells, are associated with the development of Acute Myeloid Leukemia (AML). Medullary TNF induces the local production of melatonin, which regulates self-renewal and retention of hematopoietic stem cells in BM. Althoug…