CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Assistant professor of the Department of Physiology of the Institute of Biosciences of the University of São Paulo since 2010. PhD in Sciences (General Physiology) by the Department of Physiology of the Institute of Biosciences of the University of São Paulo (2009). Bachelor in Biological Sciences by the Institute of Biosciences of the University of São Paulo (2003). Has experience in the areas of General Physiology, Pharmacology, Systems Biology and Immunology. The current research emphasis is on the characterization of neuroimmunoendocrine mechanisms associated with the development of inflammatory processes and tumors. (Source: Lattes Curriculum)
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In the mounting phase of inflammatory responses, the activation of the immune pineal axis facilitates leukocyte migration to peripheral tissues by inhibiting the production of melatonin by the pineal gland, and locally modulates the immune response due to the production of melatonin by peripheral immunocompetent cells and by glial cells of the central nervous system. Restoring the product…
The immune-pineal axis predicts, in one hand, that the melatonin produced by the pineal gland controls, in a time dependent manner, the immune response of tissues in the periphery of the body and, in the other hand, inflammatory modulators, such as cytokines and glucocorticoids, modulate the nocturnal pineal melatonin production. Glucocorticoids exert a dual effect on the pineal function,…
The melatonin produced by the pineal gland during the dark stage of the environment controls the endogenous oscillatory system of mammals, adjusting the activity of various organs, tissues and cells. Nocturnal melatonin decreases, for example, the expression of vascular endothelial adhesion molecules by reducing the migration of immunocompetent cells between the circulation and tissues. D…
Gliomas, the most frequent primary brain tumor in adults, are classified into four (I-IV) histological grades. Gliomas grade IV, known as glioblastomas, are highly aggressive tumors associated with a median survival of only 15 months. In vitro studies have shown that high concentrations of melatonin, a hormone synthesized mainly by the pineal gland, significantly reduce the migration and …
Medulloblastoma is the most common tumor in children, and to be highly aggressive and invasive, is classified as grade IV by the World Health Organization and responsible for a large proportion of infant mortality from tumors. Conventional therapies for treatment are responsible for damaging the brain tissue in children's development and often cause sequelae. Studies have reported a great…
(Only some records are available in English at this moment)
Cellular plasticity and heterogeneity are fundamental features of human tumors and arise as a consequence of genetic and epigenetic mechanisms, as well as environmental signals. Such diversity is considered an important source of treatment failure, as subpopulations of drug-resistant cells may underlie tumor recurrence and metastasis. In the tumor ecosystem, malignant and stromal cells co…
| 3 / 2 | Completed research grants |
| 8 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 8 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 50 |
| Cit./Article | 4.5 |
| Data from Web of Science | |
KINKER, GABRIELA SARTI; THOMAS, ANDREW MALTEZ; CARVALHO, VINICIUS JARDIM; LIMA, FELIPE PRATA; FUJITA, ANDRE. Deletion and low expression of NFKBIA are associated with poor prognosis in lower-grade glioma patients. SCIENTIFIC REPORTS, v. 6, APR 7 2016. Web of Science Citations: 4. (13/03447-6, 14/09576-5, 14/27287-0, 15/01507-7, 15/01587-0)
CORDOBA-MORENO, MARLINA O.; DE SOUZA, EWERTON DA SILVA; QUILES, CAROLINE L.; DOS SANTOS-SILVA, DEBORA; KINKER, GABRIELA S.; MUXEL, SANDRA M.; MARKUS, REGINA P.; FERNANDES, PEDRO A.. Rhythmic expression of the melatonergic biosynthetic pathway and its differential modulation in vitro by LPS and IL10 in bone marrow and spleen. SCIENTIFIC REPORTS, v. 10, n. 1, MAR 16 2020. Web of Science Citations: 0. (13/13691-1, 15/23348-8)
HARA, TOSHIRO; CHANOCH-MYERS, RONY; MATHEWSON, NATHAN D.; MYSKIW, CHAD; ATTA, LYLA; BUSSEMA, LILLIAN; EICHHORN, STEPHEN W.; GREENWALD, ALISSA C.; KINKER, GABRIELA S.; RODMAN, CHRISTOPHER; et al. Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. CANCER CELL, v. 39, n. 6, p. 779+, JUN 14 2021. Web of Science Citations: 7. (14/27287-0, 17/24287-8)
MONTEIRO DE ASSIS, LEONARDO VINICIUS; KINKER, GABRIELA SARTI; MORAES, MARIA NATHALIA; MARKUS, REGINA P.; FERNANDES, PEDRO AUGUSTO; DE LAURO CASTRUCCI, ANA MARIA. Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma. FRONTIERS IN ONCOLOGY, v. 8, JUN 12 2018. Web of Science Citations: 6. (12/50214-4, 14/27287-0, 13/24337-4, 14/16412-9)
BARBOSA LIMA, LEILA ELIZA; MUXEL, SANDRA MARCIA; KINKER, GABRIELA S.; CARVALHO-SOUSA, CLAUDIA EMANUELE; CRUZ-MACHADO, SANSERAY DA SILVEIRA; MARKUS, REGINA P.; CARLOS MAGNO FERNANDES, PEDRO AUGUSTO. STAT1-NF kappa B crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production. Journal of Pineal Research, v. 67, n. 3, OCT 2019. Web of Science Citations: 1. (10/52687-1, 12/09622-1, 13/13691-1)
MARKUS, REGINA P.; FERNANDES, PEDRO A.; KINKER, GABRIELA S.; CRUZ-MACHADO, SANSERAY DA SILVEIRA; MARCOLA, MARINA. Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. British Journal of Pharmacology, v. 175, n. 16, SI, p. 3239-3250, AUG 2018. Web of Science Citations: 12. (15/04557-5, 14/27287-0, 10/52687-1, 13/13691-1)
FERNANDES, PEDRO A.; TAMURA, EDUARDO K.; D'ARGENIO-GARCIA, LETICIA; MUXEL, SANDRA M.; CRUZ-MACHADO, SANSERAY DA SILVEIRA; MARCOLA, MARINA; CARVALHO-SOUSA, CLAUDIA E.; CECON, ERIKA; FERREIRA, ZULMA S.; MARKUS, REGINA P.. Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis. Neuroendocrinology, v. 104, n. 2, p. 126-134, 2017. Web of Science Citations: 11. (10/52687-1, 13/13691-1)
KINKER, GABRIELA S.; OBA-SHINJO, SUELI M.; CARVALHO-SOUSA, CLAUDIA E.; MUXEL, SANDRA M.; MARIE, SUELY K. N.; MARKUS, REGINA P.; FERNANDES, PEDRO A.. Melatonergic system-based two-gene index is prognostic in human gliomas. Journal of Pineal Research, v. 60, n. 1, p. 84-94, JAN 2016. Web of Science Citations: 8. (10/52687-1, 13/13691-1)
KINKER, GABRIELA S.; GREENWALD, ALISSA C.; TAL, ROTEM; ORLOVA, ZHANNA; CUOCO, MICHAEL S.; MCFARLAND, JAMES M.; WARREN, ALLISON; RODMAN, CHRISTOPHER; ROTH, JENNIFER A.; BENDER, SAMANTHA A.; et al. Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nature Genetics, v. 52, n. 11, p. 1208+, NOV 2020. Web of Science Citations: 0. (17/24287-8, 14/27287-0)
KINKER, G. S.; OSTROWSKI, L. H.; RIBEIRO, P. A. C.; CHANOCH, R.; MUXEL, S. M.; TIROSH, I.; SPADONI, G.; RIVARA, S.; MARTINS, V. R.; SANTOS, T. G.; et al. MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 99, n. 2, JAN 2021. Web of Science Citations: 1. (13/13691-1, 17/24287-8, 14/50943-1, 15/23348-8, 14/23830-1, 14/27287-0)
HARA, TOSHIRO; CHANOCH-MYERS, RONY; MATHEWSON, NATHAN D.; MYSKIW, CHAD; ATTA, LYLA; BUSSEMA, LILLIAN; EICHHORN, STEPHEN W.; GREENWALD, ALISSA C.; KINKER, GABRIELA S.; RODMAN, CHRISTOPHER; et al. Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. CANCER CELL, v. 39, n. 6, p. 779+, JUN 14 2021. Web of Science Citations: 7. (14/27287-0, 17/24287-8)
MONTEIRO DE ASSIS, LEONARDO VINICIUS; KINKER, GABRIELA SARTI; MORAES, MARIA NATHALIA; MARKUS, REGINA P.; FERNANDES, PEDRO AUGUSTO; DE LAURO CASTRUCCI, ANA MARIA. Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma. FRONTIERS IN ONCOLOGY, v. 8, JUN 12 2018. Web of Science Citations: 6. (12/50214-4, 14/27287-0, 13/24337-4, 14/16412-9)
BARBOSA LIMA, LEILA ELIZA; MUXEL, SANDRA MARCIA; KINKER, GABRIELA S.; CARVALHO-SOUSA, CLAUDIA EMANUELE; CRUZ-MACHADO, SANSERAY DA SILVEIRA; MARKUS, REGINA P.; CARLOS MAGNO FERNANDES, PEDRO AUGUSTO. STAT1-NF kappa B crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production. Journal of Pineal Research, v. 67, n. 3, OCT 2019. Web of Science Citations: 1. (10/52687-1, 12/09622-1, 13/13691-1)
(References retrieved automatically from State of São Paulo Research Institutions)
FERNANDES, Pedro Augusto Carlos Magno. Regulação da produção hormonal da glândula pineal de ratos por moduladores do processo inflamatório. Tese (Doutorado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (04/10922-3)