Dentist graduated by Universidade Estadual Paulista Júlio de Mesquita Filho (2002). Master and PhD in Pharmacology by Federal University of São Paulo (2005 and 2009). She completed a doctoral sandwich internship in Pharmacology at the University of Virginia (2007). She is currently General Secretary of Experimental Biology Federation (FeSBE) and an Associate Professor 3 in the Department of Pharmacology at the Institute of Biomedical Sciences of the University of São Paulo. Her main line of research is to understand how the central nervous system of mammals regulates respiration, identifying important neural circuitries in rodents using electrophysiological and neuroanatomical methods, and the changes observed in these circuitries in experimental models of neurodegenerative diseases, mainly Parkinson's disease. She is the mother of 2 girls (14 and 10 years old). (Source: Lattes Curriculum)
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Parkinson's disease (PD) is a neurodegenerative disease that affects approximately 1% of the population over 60 years. It is characterized by classic motor symptoms such as bradykinesia, tremors and postural instability. In addition, there are also autonomic non-motor symptoms (constipation, orthostatic hypotension), cognitive and respiratory changes that greatly impair patients' quality …
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra compacta (SNc). The main motor symptoms are tremor at rest, bradykinesia, classic rigidity and postural instability. However, we can observe non-motor symptoms as neuropsychiatric, sleep and breathing disorders. Neuroanatomical studies show that the nu…
Breathing automaticity and chemoreception are inseparable neural processes. The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO2 constant. Additional evidence that RTN neurons have central respiratory chemoreceptor properties is present…
(Only some records are available in English at this moment)
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the accumulation of intracellular protein and the progressive and irreversible loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc), which leads to a decrease in the dopamine in the striatum. The deficiency of this neurotransmitter leads to the classic motor symptoms of PD, such as tremors and p…
Parkinson's Disease (PD) is the second most common neurodegenerative disease observed in the population and is mainly characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and by producing classic symptoms such as tremor, muscle rigidity and bradykinesia. However, PD is also responsible for generating other non-classical symptoms, such as respiratory dysfunction, …
Parkinson's disease (PD) is a neurodegenerative disorder characterized by reduction in the number of dopaminergic neurons in the substantia nigra pars compacta (SNpc). PD patients have classical motor symptoms exemplified by tremors and postural instability, and non-classical symptoms such as sleep disorders and respiratory deficit, that little is known. Recent studies from our laboratory…
Parkinson's disease (PD) is a neurodegenerative disorder known for its progressive loss of dopaminergic neurons in the compact portion of the substantia nigra (SNpc). Much less known, although clinically very important, are the damaging effects on respiration associated with PD. Studies using the 6-hydroxydopamine (6-OHDA) model in rats revealed reduced respiratory rate (fR), central chem…
Parkinson's disease (PD) is a neurodegenerative disorder that is associated with loss of dopaminergic neurons in the substantia nigra compacta (SNpc) leading to a reduction of dopamine in the nigrostriatal pathway. The motor symptoms are characterized by tremor and bradykinesia while the non-motor symptoms include cognitive deficiencies, sleeping and sensorial disturbances and breathing i…
Parkinson's disease (PD) is a debilitating neurological condition that affects approximately 1% of the elderly population. It is characterized by motor symptoms, such as bradykinesia, tremors, and postural instability. In addition, non-motor autonomic symptoms can be present, such as constipation, orthostatic hypotension and respiratory abnormalities. The respiratory symptoms, such as obs…
(Only some records are available in English at this moment)
Parkinson´s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra compacta (SNpc). We can observe non-motor symptoms as neuropsychiatric, sleep and breathing disorders. It was noticed in post-mortem humans brains and in 6-hydroxydopamine (6-OHDA) rat model of PD a significant reduction of neurokinin 1 receptor (NK1r)…
Parkinson's disease (PD) is a disorder characterized by motor and non-motor symptoms, such as respiratory deficits and is associated with loss of dopaminergic neurons in the compact part of the substantia nigra (SNc). However, other brainstem neurons may also be degenerated, contributing to the appearance of non-motor abnormalities. Previous study showed a decrease in the number of phox2b…
| 6 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 14 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 28 / 25 | All research grants and scholarships |
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