Virginia Picanço e Castro
CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Hemocentro de Ribeirão Preto (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the University of São Paulo (1999) and Ph.D. in Applied Sciences the medical field by FMRP-USP (2006) Sandwich PhD at the University of Frankfurt, Germany (2004), in the production of recombinant coagulation factors. Has a postdoctoral internship abroad at the University of Indianapolis, IUPUI, USA (2008), in the generation of induced pluripotent stem cells (iPS). During the period of one year was Senior Researcher in a Biotechnology Company located in at USP-Campus, Vertias Life Science. Currently, is a CTC-USP researcher at the Blood Center of Ribeirão Preto.I have experience in molecular biology, with emphasis on expression of recombinant proteins and Cell Biology, with an emphasis on the cultivation of mammalian cells and embryonic stem cells and iPS (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Patent mining indicates promising routes for research |
- Purification, formulation and preclinical testing of recombinant FVIII produced in human cells, AP.R
Abstract
Hemophilia is a genetic disorder linked to the X chromosome which results in deficiency or abnormality of factor VIII protein (FVIII). The replacement therapy using protein derived from human plasma or recombinant produced in hamster cell lines (CHO and / or BHK) are the only treatment options available. However, one of the largest replacement therapy problems is the formation of inhibi...
- Modification of t cells with anti-CD19 chimeric antigen receptor, BP.MS
Abstract
Immunotherapy with modified T cells to express chimeric antigen receptor (CAR) has been proven effective in remission of acute lymphoblastic leukemia (ALL) in children and young adults. The CAR possess an extracellular domain derived from antibody variable regions, and intracellular domains of T cell costimulation. CD19 protein has been shown to be an ideal target for therapies with CAR...
- Obtaintion of erythrocytes from induced pluripotent stem cells in feeder-free culture with xeno-free culture medium, BP.MS
Abstract
Hematopoiesis is the process of formation of blood cellular components from the differentiation of hematopoietic stem cells (HSC). The HSCs are found in adult human bone marrow cells at a ratio of 1 in every 10^6 cells. The difficulty in obtaining these cells and determining a protocol for ex vivo expansion leads us to seek alternative sources for the production of mature blood cells. I...
- Determination of the Oct4 pluripotency gene targets on human mesenchymal stem cells, BP.IC
| 1 / 1 | Completed research grants |
| 7 / 3 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 9 / 4 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 2 |
| Citations | 7 |
| Cit./Article | 3.5 |
| Data from Web of Science | |
PASSOS‚ G.A.S.; PROENÇA PICANÇO‚ V.. Frequency of the δ< i> ccr 5 deletion allele in the urban Brazilian population. Immunology Letters, v. 61, n. 2, p. 205-207, 1998.
CORREA DE FREITAS, MARCELA CRISTINA; BOMFIM, ALINE DE SOUSA; MIZUKAMI, AMANDA; PICANCO-CASTRO, VIRGINIA; SWIECH, KAMILLA; COVAS, DIMAS TADEU. Production Of coagulation factor VII in human cell lines Sk-Hep-1 and HBK-11. Protein Expression and Purification, v. 137, p. 26-33, SEP 2017. Web of Science Citations: 1. (16/02433-0, 11/01736-5, 13/08135-2)
MARTINS FERNANDES PAES, BARBARA CRISTINA; MOCO, PABLO DIEGO; PEREIRA, CRISTIANO GONCALVES; PORTO, GECIANE SILVEIRA; DE SOUSA RUSSO, ELISA MARIA; JUNQUEIRA REIS, LUIZA CUNHA; COVAS, DIMAS TADEU; PICANCO-CASTRO, VIRGINIA. Ten years of iPSC: clinical potential and advances in vitro hematopoietic differentiation. CELL BIOLOGY AND TOXICOLOGY, v. 33, n. 3, p. 233-250, MAY 2017. Web of Science Citations: 6. (16/08373-9, 14/22500-8, 16/08374-5, 13/08135-2)