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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Hemocentro de Ribeirão Preto (Institutional affiliation for the last research proposal) Birthplace: Brazil
Virginia Picanço e Castro in research grants and scholarships supported by FAPESP.
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The Nucleus of Cellular Therapy - NuTeC will be founded on the union of the Regional Blood Center of Ribeirão Preto (Hemocentro RP) and Butantan. Hemocentro RP expertise in cellular therapy will be added to Butantan excellence in the development and production of health applied products to develop CAR T cell therapy. The activities to be conducted by NuTeC are aligned with the scope of th…
In recent years, enormous advances have been made in genetic engineering of effector immune cells for cancer therapy. Although chimeric antigen receptors (CARs) have been widely used to redirect autologous T cell specificity against haematological malignancies, yielding impressive clinical results, studies with CAR-modified natural killer (NK) cells are still restricted to preclinical stu…
Hemophilia is a genetic disorder linked to the X chromosome which results in deficiency or abnormality of factor VIII protein (FVIII). The replacement therapy using protein derived from human plasma or recombinant produced in hamster cell lines (CHO and / or BHK) are the only treatment options available. However, one of the largest replacement therapy problems is the formation of inhibito…
The development of chimeric antigen receptor T cells (CAR-T) therapy brought significant advances in hematological cancers treatment. It combines the cytotoxic activity of autologous T cells with antibody specificity. For refractory or relapsed B-cell malignancies, the CD19 antigen has been the main target explored, as it is expressed mainly in B cells. Despite an increase in remission ra…
Immunotherapy with modified T cells to express chimeric antigen receptor (CAR) has been proven effective in remission of acute lymphoblastic leukemia (ALL) in children and young adults. The CAR possess an extracellular domain derived from antibody variable regions, and intracellular domains of T cell costimulation. CD19 protein has been shown to be an ideal target for therapies with CAR b…
Hematopoiesis is the process of formation of blood cellular components from the differentiation of hematopoietic stem cells (HSC). The HSCs are found in adult human bone marrow cells at a ratio of 1 in every 10^6 cells. The difficulty in obtaining these cells and determining a protocol for ex vivo expansion leads us to seek alternative sources for the production of mature blood cells. Ind…
| 2 / 2 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 3 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 12 / 7 | All research grants and scholarships |
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