Beatriz da Costa Aguiar Alves Reis in research grants and scholarships supported by FAPESP.
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The continued growth and progression of tumor cell requires a high bioenergetics expenditure. The more efficient cellular process to generate energy is glucose metabolism; despite adequate glucose uptake, not all cells have an adequate supply of oxygen available for their metabolism. Hypoxia is the term used to describe the deficiency of oxygen in some tissues. Tumor cells are particularl…
Background: Patients with breast cancer-the deadliest cancer among women-are at constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of tumor cells that can proliferate even in a resultant metabolic acidosis. Despite the low extracellular pH, intracellular pH of tumor cells remains relatively normal, or even more alkaline due to the action of a membrane …
Breast cancer is the leading cause of cancer mortality among women and these patients are under the risk of developing metastases. The heterogeneous nature of these metastases makes it difficult not only the definition of healing, as well as the risk factors for its development. Currently, some prognostic markers already assist clinical practice, and the most used are hormone receptors (E…
In neoplasms, ROS act as signaling molecules contributing to tumorigenesis. The antioxidant response is mediated by the Keap1-NRF2-ARE complex, negatively regulated by the BACH1 gene. In breast cancer, elevated BACH1 expression is linked to increased recurrence, while its decrease reduces the risk of metastasis. BACH1 also influences IRE1±, crucial in endoplasmic reticulum (ER) homeostasi…
Breast cancer is the most frequent and the major cause of death from this disease among women, especially in view of the possibility of metastasis. Thus, the severity of this disease is evident, becoming a reason for global concern, emphasizing the need for greater attention at various levels of disease management, from screening to diagnosis, treatment and prognosis. Tumor development de…
The maintenance of growth and progression of the tumor cell requires high bioenergetics expenditure. The most efficient cellular process of energy generation is glucose metabolism; despite proper glucose uptake, not all cells have at their disposal the adequate supply of oxygen for their metabolism. Hypoxia is the term used to describe oxygen deficiency in some tissues. Tumor cells are pa…
Breast cancer is the leading cause of cancer mortality among women and these patients are under the risk of developing metastases. The heterogeneous nature of these metastases makes it difficult not only the definition of healing, as well as the risk factors for its development. Currently, some prognostic markers already assist clinical practice, and the most used are hormone receptors (E…
| 5 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 3 | Completed scholarships in Brazil |
| 11 / 7 | All research grants and scholarships |
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