CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina Veterinária e Zootecnia (FMVZ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Veterinary Medicine from the School of Veterinary Medicine and Animal Science (FMVZ) - Sao Paulo State University (Unesp - campus Botucatu - Brazil, 1991), Residency in Large Animal Internal Medicine (1992-1993) with specialization in Veterinary Neurology, Master's degree (1997) and PhD (2002) in Veterinary Clinic by FMVZ-Unesp. Postdoctoral degree in cell therapy at the Veterinary Institute for Regenerative Cures - University of California, Davis - USA. He works with Veterinary Neurology and cell-based therapy. (Source: Lattes Curriculum)
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Inflammatory injuries of the central nervous system (CNS) are particularly disabling for both human and domestic animals. Multiple Sclerosis (MS) in humans and Meningoencephalomyelitis of Unknown Origin (MUO) in dogs are the most common neuroimmune diseases. The Experimental Autoimmune Encephalomyelitis (EAE) in mice, as animal model for MS, has contributed to the understanding of the pat…
Researches with mesenchymal stem cells (MSCs) and tissue engineering have shown that prospects will likely benefit the health of both humans and domestic animals, among them performance horses. The high differentiation potential of MSCs in different cell types, it's easy expansion in culture and the possibility of transplants have led to increased research into these cells. The therapeuti…
Horses with immune-mediated or autoimmune diseases have an exacerbated inflammatory response that is difficult to control, with a prognosis reserved, generating significant expenses with medications. The conventional treatment with the use of steroidal or non-steroidal anti-inflammatory drugs, has high potential to cause gastrointestinal and renal adverse effects. Asalternative treatment,…
The Endocannabinoid System constitutes a complex set of signaling pathways whose functions range from presynaptic neuronal inhibition to immunomodulation. The system's endogenous messengers are lipids synthesized on demand (anandamide and 2-arachidonoyl glycerol) that interact with G protein-coupled receptors (CB1 and CB2). CB1 receptors are found primarily in the central nervous system (…
Obesity is a growing disease in the human population and in the canine population. Data indicate that about 20% of dogs in industrialized countries are obese. The etiology of this disease is directly related to an energy imbalance, in which the animal obtains more energy than it actually needs, causing accumulation of it. The energetic excess is stored in the form of lipids in the adipose…
Canine Meningoencephalomyelitis of unknown origin (MUO) is a common, highly debilitating neuroinflammatory disease, and likely of an immune-mediated origin. Affected dogs require aggressive immunosuppressive treatment in the long-term, however, treatment failure and severe adverse effects usually occur. MUO has pathophysiological, clinical and histopathological similarities to Multiple Sc…
Functional recovery after complete peripheral nerve transection is poor and incomplete, occurring axonal degeneration, wich is characterized by myelin fragmentation and separation. Although the peripheral nervous system presents an inherent capacity for regeneration, severe injuries do not allow nerve stumps reconnection. For proper nerve regeneration is essential to maintain a permissive…
(Only some records are available in English at this moment)
Over the past decade, stem cell therapy has become a corner stone in translational and regenerative medicine for many diseases. However, brain and spinal cord diseases represent a challenge in stem cell based therapy. Stem cells therapies for CNS injury can be driven either with cell replacement by transplanted stem cells or by stimulation of endogenous CNS stem cells; and by the improvem…
Mesenchymal stem cells (MSCs) are a promising tool for treatment of a variety of injuries and disorders because of their secretion of numerous bioactive molecules leading to tissue regeneration. The central nervous system (CNS) has a limited capacity for regeneration. As such, MSCs are being evaluated as a cell therapy for a number of chronic degenerative and inflammatory neurological con…
| 3 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 8 / 6 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 15 / 12 | All research grants and scholarships |
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