- Research Grants
Full Professor of the Department of Cell Biology and Development, Institute of Biomedical Sciences (ICB), University of São Paulo (USP), graduated in Medicine from the Faculty of Medicine of Ribeirão Preto - University of São Paulo (1980) and obtained the degrees of Master (1991) and Doctorate (1994) in Medicine (Clinical Endocrinology) at the Paulista School of Medicine - Unifesp and Associate Professor (2005) at ICB-USP. She is member of the Latin American Thyroid Society (LATS), the American Thyroid Association (ATA), the American Association for Cancer Research (AACR), the European Society for Paediatric Endocrinology (ESPE), the Brazilian Cellular Biology Society (SBBC) and the Brazilian Society of Endocrinology and Metabology (SBEM). She served as members of board of directors of LATS and SBEM-Thyroid, and as chair of SBEM-Thyroid Department (2009-2010). She was editor-in-chief (2007 -2010) of the Archives of Endocrinology & Metabolism (AE&M) - formely Arquivos Brasileiros de Endocrinologia e Metabologia (ABE&M). Currently she contributes to the the editorial board of THYROID (EUA), AE&M (Brazil), Brazilian J Med & Biol Research (Brazil). The field of her research covers the understanding of Thyroid and Goiter Cancer tumorigenesis, with emphasis on the signaling pathways MAPK (BRAF), TGFbeta, iodine and microRNA using in vitro and in vivo models that include techniques of molecular biology, histology, cell biology, genomics, gene editing and animal model. She has been mentored undergraduate, graduate students and pos-doctoral fellows, and some of them presently are scientists in Brazil and abroad. For her contribution to the thyroid research she was awarded with the LATS Prize by the Latin American Thyroid Society in 2009 and the EBT-2016 Prize by the Department of Thyroid - SBEM. (Source: Lattes Curriculum)
Global incidence of thyroid cancer has increased in the last years, stating this type of cancer as the most common of the endocrine system. Although having a good prognosis, a fraction of thyroid cancers becomes refractory to conventional therapy of radioiodine ablation after thyroid tumor resection due to a more aggressive behavior. Despite the well characterized role for MAPK signalin...
Papillary thyroid cancer (PTC) is the most common histotype of thyroid cancer whose incidence has been rising progressively in the last decade. The most prevalent genetic alteration in PTC is BRAF mutation (BRAFT1799A), detected in more than 45% of patients. This mutation activates constitutively MAPK pathway, and moreover, amplify other signaling pathways involved in cell proliferation...
(Only some records are available in English at this moment)
Genetic alterations in BRAF, RAS or RET genes are associated to thyroid cancer oncogenesis, being BRAFT1799A (BRAFV600E) mutation the most frequent and associated with greater aggressiveness and poor prognosis. Aggressive thyroid carcinomas show loss of cell differentiation and improved capacity of invasion and migration, due to the activation of epithelial-mesenchymal transition proces...
Genetic alterations in oncogenes and tumor supressor genes deregulate signaling pathways involved in proliferation, apoptosis and cell survival. Recently, microRNAs (miRNAs), small endogenous RNA that negatively regulate specific target mRNAs translation, have been implicated in oncogenesis, The expression of some miRNAs is associated to more aggressive cancers such as the cluster of mi...
MicroRNAs (miRNA) are small endogenous non-coding RNAs that negatively regulate protein expression and biological processes such as proliferation, differentiation and apoptosis. The miRNA biogenesis consists of multistep events of RNA synthesis and processing that begin within the nucleus and end in the cytoplasm. Some miRNAs, called oncomiRs, participate in the tumorigenesis by inhibit...
(Only some records are available in English at this moment)
Thyroid cancer is the most frequent endocrine neoplasia and fifth most incident cancer in women. Papillary thyroid cancer (PTC) comprises 90% of thyroid cancer cases and presents good prognosis and curative treatment options. However, undifferentiated PTC and anaplastic thyroid cancer (ATC) are marked by loss of differentiation, i.e. loss of thyroid markers such as NIS, TPO, Tg and TSHR...
miRNA deregulation is an important step in oncogenesis associated with activation of oncogenic pathway and inhibition of tumor-suppressor genes. During tumor progression, a complex network of miRNAs and its targets are modulated which is likely to contribute to metastatic phenotype and tumor spreading. Metastases are the main cause of cancer-related death, particularly lung cancer, whic...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
MARTINS, Luciane. A galectina-3 na fisiologia e no câncer de tiróide: identificação de SNPs no gene LGALS3 e estudo funcional de galectina-3 in vitro e in vivo. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (02/12772-3)
FUZIWARA, Cesar Seigi. Influência do MicroRNA let-7 e miR-17-92 como oncomiRs no câncer.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (08/51739-8)
DZIK, Luciana Machado. A influência do microRNA miR-21 no câncer de tiróide.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/04499-4)
GERALDO, Murilo Vieira. Regulação da via de sinalização de TGF-b pelo microRNA miR- 146b-5p no câncer de tiróide.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (07/51927-6)
FIORE, Ana Paula Zen Petisco. Influência do excesso de iodo na ativação do oncogene RET/PTC3 na linhagem PCCL3 de tiróide de rato.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/57957-9)
REZENDE, Eloiza de. Estudo da expressão de Arkadia, proteína E3 de ubiquitinação, em tumores de tiróide e sua relação com a via de sinalização de TGF-Beta.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (06/53797-0)
FUZIWARA, Cesar Seigi. O cluster de microRNAs miR-17-92 e seus alvos na oncogênese tiroidiana: influência de BRAFT1799A e de iodo.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/51704-0)
OLIVÉ, Aline Nogueira. Influência de Lin28 na expressão de let-7f no câncer papilífero de tiroide.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (12/14325-6)