CV Lattes
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Associate Professor in the Department of Genetics, Evolution, Microbiology and Immunology of the Biology Institute of the State University of Campinas (Unicamp) from August 1978 to September 2017. Graduated in Biological Sciences by UNICAMP in 1975. Master in Biology (Immunology) by UNICAMP, in 1980. PhD in Sciences (Immunology) by UNICAMP, in 1988. Post-doctorate in Pharmacology by the University of São Paulo (USP / RP), with grants from CNPq, in 1989 and 1991. Postdoctoral fellow at Genentech Inc., San Francisco, CA, with a fellowship from FAPESP, in 1990. Experience in researching the following subjects: Chagas' disease, innate immunity, oral tolerance, experimental arthritis and colitis, monoclonal antibodies. (Source: Lattes Curriculum)
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Rheumatoid arthritis (RA) is an autoimmune disease that affects human cartilage and synovial tissue, due to the activation of T and B lymphocytes reactive to type II collagen present in the joints. Although there is no experimental model that mimics all the features of human disease, the collagen-induced arthritis (CIA) in mice DBA/1 is the main model for study of this disease. Recently i…
Aging is accompanied by a decrease in several physiological functions that make older individuals less responsive to environmental challenges. In this study, we analyzed the immune response of female BALB/c mice (n = 6) of different ages (from 2 to 96 weeks of age) and identified significant age-related alterations. Immunization with hapten-protein (trinitrophenyl-bovine serum albumin, TN…
Rheumatoid arthritis is an autoimmune disease that affects human cartilage and synovial tissue, due to the activation of T and B lymphocytes reactive to type II collagen present in the joints. It is thus a disease with characteristic of cellular and humoral immune response. Although there is not an experimental model that mimics all the features of human disease, the collagen-induced arth…
Intestinal mucosa is a portal of entry for most pathogens that invade the body. The immune response generated in these tissues may present different characteristics, ranging from the elimination of pathogens to the local or systemic tolerance to dietary antigens. The tolerogenic response that follows the intake of proteins is characterized by low levels or absence of either specific antib…
Immune response in gastrointestinal trait usually results in pathogen elimination. However, dietary proteins as well as comensal microrganisms are tolerated antigens. Tolerance acquired by ingestion of proteins seems to depend on the generation of regulatory or supressor T cells, but dendritic cells (DCs) might be deeply involved in this process. Cytokines from Th1 or Th2 cells may influe…
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LEO‚ P.; UCELLI‚ P.; AUGUSTO‚ EFP; OLIVEIRA‚ MS; TAMASHIRO‚ W.. Anti-TNP monoclonal antibodies as reagents for enzyme immunoassay (ELISA). HYBRIDOMA, v. 19, n. 6, p. 473-479, 2000.
THOME, RODOLFO; ROMANI FERNANDES, LUIS GUSTAVO; MINEIRO, MARCELA FRANCO; SIMIONI, PATRICIA UCELLI; JOAZEIRO, PAULO PINTO; DA SILVA CUNHA TAMASHIRO, WIRLA MARIA. Oral tolerance and OVA-induced tolerogenic dendritic cells reduce the severity of collagen/ovalbumin-induced arthritis in mice. Cellular Immunology, v. 280, n. 1, p. 113-123, NOV 2012. (09/05891-5, 09/01838-2)
SIMIONI, PATRICIA U.; FERNANDES, LUIS G. R.; TAMASHIRO, WIRLA M. S. C.. Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, v. 30, n. 1, p. 44-57, MAR 2017. (08/05466-0)
P.U. SIMIONI; E.H. COSTA; W.M.S.C. TAMASHIRO. Aging reduces the primary humoral response and the in vitro cytokine production in mice. Brazilian Journal of Medical and Biological Research, v. 40, n. 8, p. 1111-1120, Ago. 2007.
JUSTO, OSELYS RODRIGUEZ; SIMIONI, PATRICIA UCELLI; GABRIEL, DIRCE LIMA; DA SILVA CUNHA TAMASHIRO, WIRLA MARIA; VIEIRA ROSA, PAULO DE TARSO; MORAES, ANGELA MARIA. Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v. 15, OCT 29 2015. (05/03507-2, 15/21365-2, 05/04496-4)
RUBERTI, MARISTELA; ROMANI FERNANDES, LUIS GUSTAVO; SIMIONI, PATRICIA UCELLI; GABRIEL, DIRCE LIMA; YAMADA, AUREO TATSUMI; DA SILVA CUNHA TAMASHIRO, WIRLA MARIA. Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2012.
(References retrieved automatically from State of São Paulo Research Institutions)
THOMÉ, Rodolfo. Modulação da artrite experimental induzida pela associação de colágeno tipo II e ovalbumina. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/01838-2)
COSTA, Ellen Heidi. Estudo da resposta inflamatoria de camundongos : produção de oxido nitrico e de citocinas no envelhecimento. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (94/04215-9)