Abstract
Rheumatoid arthritis (RA) is an autoimmune disease that affects human cartilage and synovial tissue, due to the activation of T and B lymphocytes reactive to type II collagen present in the joints. Although there is no experimental model that mimics all the features of human disease, the collagen-induced arthritis (CIA) in mice DBA/1 is the main model for study of this disease. Recently i…