CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Quimica from Universidade Estadual Paulista Júlio de Mesquita Filho (1984), master's at Biochemistry from Universidade Federal de São Paulo (1991) and Ph.D. at Biochemistry from Universidade Federal de São Paulo (1993). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: insects, ticks, R. microplus, proteinase inhibitor, proteases, phage display, transcriptome, vector-parasite interations. (Source: Lattes Curriculum)
The severe acute respiratory syndrome COVID-19 caused by the coronavirus SARS-CoV-2 is an emerging and highly contagious disease, with which the world is experiencing a pandemic from the end of 2019 to the present day, which has led several countries to bankruptcy public health service, and soon Brazil will reach this situation. Today (13/04/2020) there are already at least 22300 people i…
Neglected diseases are responsible for epidemics with countless deaths each year in many countries, especially in developing countries. Most neglected diseases are transmitted by hematophagous vectors. Over the last decades, our group has been working on the prospection of active molecules produced by hematophagous arthropods, vectors of diseases. In the last project, our group evaluated …
The goal of this application is to initiate collaborative research between the laboratory of Albert Mulenga and Aparecida Tanaka to the advance exchange of ideas and student training between the two laboratories. The TAMU and São Paulo principal investigators work on complementary research lines, to develop transmission blocking vacines to prevent transmission of vector borne disease agen…
The knowledge of the diversity of molecules produced by disease vectors in response to their etiologic agents is an important strategy to identify important targets in these vectors physiology, which could be used in rational design of drugs and pesticides. In attempt to contribute in this research field, this project has as general objective understand the role of protease inhibitors, pr…
(Only some records are available in English at this moment)
The severe acute respiratory syndrome COVID-19 caused by the coronavirus SARS-CoV-2 is an emerging and highly contagious disease, with which the world is experiencing a pandemic from the end of 2019 to the present day, which has led several countries to bankruptcy public health service, and soon Brazil will reach this situation. Today (13/04/2020) there are already at least 22300 people i…
Rhipicephalus (Boophilus) microplus is a tick species present in Brazil and well known to parasite cattle. High levels of parasitism can seriously affect the animals, resulting in reduced milk and meat production and causing substantial economic losses to the livestock. In addition, this species can transmit different etiologic agents to cattle, including those that cause babesiosis and a…
Aedes aegypti females are the main vectors responsible for the transmission of causative agents of Dengue, Yellow Fever, Chikungunya and Zika due to their blood-sucking habits. When mosquitoes ingest infected blood, an immune response begins, and the pathogen induces changes in their protein expressions. However, little is known about which molecules are produced or modulated in Ae. aegyp…
The present propose is included in the thematic project with the following aim: study of the physiological role of proteases and their inhibitors identified in ectoparasites that concern public health and livestock production. Among these vectors, we have been studied: the tick Rhipicephalus (Boophilus) microplus, responsible for the transmission of Babesia bovis protozoa and Anaplasma ma…
The tick R. microplus is consider a parasite of great veterinary importance in tropical and subtropical regions around the world, being responsible for big losses in the production of leather, milk and meat, besides it acts as vector of Babesia sp and Anaplasma sp, which compromise even more the cattle. Until now the tick control has been done by using acaricides, however its improper use…
Rhipicephalus microplus tick is the major ectoparasite in tropical and sub-tropical regions of the globe. Its hematophagous habit cause severe anemia, reduction in the production of meat and milk and can transmit pathogens such as Anaplasma and Babesia. The complex R. microplus-Babesia has a major impact in livestock production, although little is known about the mechanism of invasion and…
(Only some records are available in English at this moment)
The Rhicepicephalus microplus tick is the major bovine ectoparasite in the tropical and sub-tropical regions of the world and is responsible for several losses in the livestock production. Moreover the tick acts as vector for two bovine pathogens the protozoan Babesia and the bacteria Anaplasma, which can cause further cattle damage. Although the R. microplus-Babesia is considered one of …
| 3 / 3 | Ongoing research grants |
| 14 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 33 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 54 / 25 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 29 |
| Citations | 215 |
| Cit./Article | 7.4 |
| Data from Web of Science | |
LU, STEPHEN; DA ROCHA, LETICIA A.; TORQUATO, RICARDO J. S.; VAZ JUNIOR, ITABAJARA DA SILVA; FLORIN-CHRISTENSEN, MONICA; TANAKA, APARECIDA S.. A novel type 1 cystatin involved in the regulation of Rhipicephalus microplus midgut cysteine proteases. TICKS AND TICK-BORNE DISEASES, v. 11, n. 3, MAY 2020. Web of Science Citations: 0. (15/09268-1, 12/03657-8, 17/25609-9)
GOMES, CICERA MARIA; DE MORAIS-ZANI, KAREN; LU, STEPHEN; BUARQUE, DIEGO DE SOUZA; CARDOSO BRAZ, GLORIA REGINA; GREGO, KATHLEEN FERNANDES; TANAKA, APARECIDA SADAE; TANAKA-AZEVEDO, ANITA MITICO. Differential transcript profile of inhibitors with potential anti-venom role in the liver of juvenile and adult Bothrops jararaca snake. PeerJ, v. 5, APR 27 2017. Web of Science Citations: 2. (13/05357-4, 14/11108-0, 12/03657-8)
BUARQUE, DIEGO S.; GOMES, CICERA M.; ARAUJO, RICARDO N.; PEREIRA, MARCOS H.; FERREIRA, ROBERTA C.; GUARNERI, ALESSANDRA A.; TANAKA, APARECIDA S.. A new antimicrobial protein from the anterior midgut of Triatoma infestans mediates Trypanosoma cruzi establishment by controlling the microbiota. Biochimie, v. 123, p. 138-143, APR 2016. Web of Science Citations: 6. (12/00723-0, 12/03657-8)
SOARES, TATIANE S.; BUARQUE, DIEGO S.; QUEIROZ, BRUNA R.; GOMES, CICERA M.; BRAZ, GLORIA R. C.; ARAUJO, RICARDO N.; PEREIRA, MARCOS H.; GUARNERI, ALESSANDRA A.; TANAKA, APARECIDA S.. A Kazal-type inhibitor is modulated by Trypanosoma cruzi to control microbiota inside the anterior midgut of Rhodnius prolixus. Biochimie, v. 112, p. 41-48, MAY 2015. Web of Science Citations: 13. (12/00723-0, 12/03657-8)
LU, STEPHEN; SOARES, TATIANE S.; VAZ JUNIOR, ITABAJARA S.; LOVATO, DIOGO V.; TANAKA, APARECIDA S.. Rmcystatin3, a cysteine protease inhibitor from Rhipicephalus microplus hemocytes involved in immune response. Biochimie, v. 106, p. 17-23, NOV 2014. Web of Science Citations: 7. (05/03514-9, 09/17589-1, 12/03657-8)
CAMPOS, I. T. N.; SOUZA, T. A. C. B.; TORQUATO, R. J. S.; DE MARCO, R.; TANAKA-AZEVEDO, A. M.; TANAKA, A. S.; BARBOSA, J. A. R. G.. The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v. 68, n. 6, p. 695-702, JUN 2012. Web of Science Citations: 16. (01/07535-0, 05/03514-9)
DE MARCO, RENATO; AZZOLINI, SIMONE S.; LOVATO, DIOGO V.; TORQUATO, RICARDO J. S.; AMINO, ROGERIO; DE MIRANDA, ANTONIO; TANAKA, APARECIDA S.. Validation of a Phage Display Method for Protease Inhibitor Selection Using SFTI and HiTI Synthetic Hybrid Peptides. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, v. 13, n. 9, p. 829-835, NOV 2010. Web of Science Citations: 2. (05/03514-9)
LOVATO‚ D.V.; NICOLAU DE CAMPOS‚ I.T.; AMINO‚ R.; TANAKA‚ A.S.. The full-length cDNA of anticoagulant protein infestin revealed a novel releasable Kazal domain‚ a neutrophil elastase inhibitor lacking anticoagulant activity. Biochimie, v. 88, n. 6, p. 673-681, 2006.
MALAVAZI-PIZA‚ K.C.; ARAÚJO‚ M.S.; GODINHO‚ R.O.; TANAKA‚ A.S.. Effect of invertebrate serine proteinase inhibitors on carrageenan-induced pleural exudation and bradykinin release. International Immunopharmacology, v. 4, n. 10, p. 1401-1408, 2004.
ABREU, PATRICIA A.; SOARES, TATIANE S.; BUARQUE, DIEGO S.; TORQUATO, RICARDO S.; TANAKA, APARECIDA S.. RmKK, a tissue kallikrein inhibitor from Rhipicephalus microplus eggs. Biochemical and Biophysical Research Communications, v. 449, n. 1, p. 69-73, JUN 20 2014. Web of Science Citations: 3. (05/03514-9, 12/03657-8)
WATANABE, RENATA M. O.; TANAKA-AZEVEDO, ANITA M.; ARAUJO, MARIANA S.; JULIANO, MARIA A.; TANAKA, APARECIDA S.. Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type inhibitor from Aedes aegypti with anticoagulant activity. Biochimie, v. 93, n. 3, p. 618-623, 2011. Web of Science Citations: 13. (05/03514-9)
SASAKI‚ S. D.; AZZOLINI‚ S. S. A.; HIRATA‚ I. Y.; ANDREOTTI‚ R.; TANAKA‚ A. S.. Boophilus microplus tick larvae‚ a rich source of Kunitz type serine proteinase inhibitors. Biochimie, v. 86, n. 9/10, p. 643-649, Sept.-Oct. 2004.
SOARES, TATIANE SANCHES; SOARES TORQUATO, RICARDO JOSE; ALVES LEMOS, FRANCISCO JOSE; TANAKA, APARECIDA SADAE. Selective inhibitors of digestive enzymes from Aedes aegypti larvae identified by phage display. Insect Biochemistry and Molecular Biology, v. 43, n. 1, p. 9-16, JAN 2013. Web of Science Citations: 5. (05/03514-9, 09/05405-3)
BUARQUE, DIEGO S.; SPINDOLA, LETICIA M. N.; MARTINS, RAFAEL M.; BRAZ, GLORIA R. C.; TANAKA, APARECIDA S.. Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruzi. Biochemical and Biophysical Research Communications, v. 413, n. 2, p. 241-247, SEP 23 2011. Web of Science Citations: 9. (05/03514-9)
WATANABE, RENATA M. O.; SOARES, TATIANE S.; MORAIS-ZANI, KAREN; TANAKA-AZEVEDO, ANITA M.; MACIEL, CERES; CAPURRO, MARGARETH L.; TORQUATO, RICARDO J. S.; TANAKA, APARECIDA S.. A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity. Biochimie, v. 92, n. 8, p. 933-939, AUG 2010. Web of Science Citations: 20. (05/03514-9)
SOARES‚ T.S.; WATANABE‚ R.M.O.; LEMOS‚ F.J.A.; TANAKA‚ A.S.. Molecular characterization of genes encoding trypsin-like enzymes from< i> Aedes aegypti larvae and identification of digestive enzymes. GENESIS, v. 489, n. 2, p. 70-75, 2011. (05/03514-9)
SOARES, TATIANE S.; WATANABE, RENATA M. O.; LEMOS, FRANCISCO J. A.; TANAKA, APARECIDA S.. Molecular characterization of genes encoding trypsin-like enzymes from Aedes aegypti larvae and identification of digestive enzymes. Gene, v. 489, n. 2, p. 70-75, DEC 10 2011. Web of Science Citations: 18. (05/03514-9)
KARLA A. OLIVEIRA; RICARDO J. S. TORQUATO; DANIELA C. G. GARCIA LUSTOSA; TALES RIBEIRO; BRUNO W. L. NASCIMENTO; LILIAN C. G. DE OLIVEIRA; MARIA A. JULIANO; THAYSA PASCHOALIN; VIRGINIA S. LEMOS; RICARDO N. ARAUJO; et al. Proteolytic activity of Triatoma infestans saliva associated with PAR-2 activation and vasodilation. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, p. -, 2021. Web of Science Citations: 0. (12/03657-8)
SOARES, TATIANE S.; OLIVEIRA, FELIPE; TORQUATO, RICARDO J. S.; SASAKI, SERGIO D.; ARAUJO, MARIANA S.; PASCHOALIN, THAYSA; TANAKA, APARECIDA S.. BmTI-A, a Kunitz type inhibitor from Rhipicephalus microplus able to interfere in vessel formation. Veterinary Parasitology, v. 219, p. 44-52, MAR 30 2016. Web of Science Citations: 7. (05/03514-9, 12/03657-8)
TORQUATO, RICARDO J. S.; LU, STEPHEN; MARTINS, NADIA HELENA; TANAKA, APARECIDA S.; BARBOSA PEREIRA, PEDRO JOSE. High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 73, n. 8, p. 469-475, AUG 2017. Web of Science Citations: 1. (12/03657-8)
CARDOSO, THYAGO H. S.; LU, STEPHEN; GONZALEZ, BORIS R. G.; TORQUATO, RICARDO J. S.; TANAKA, APARECIDA S.. Characterization of a novel cystatin type 2 from Rhipicephalus microplus midgut. Biochimie, v. 140, p. 117-121, SEP 2017. Web of Science Citations: 1. (11/09340-3, 12/03657-8)
SOARES, TATIANE SANCHES; RODRIGUEZ GONZALEZ, BORIS LUIS; SOARES TORQUATO, RICARDO JOSE; ALVES LEMOS, FRANCISCO JOSE; COSTA-DA-SILVA, ANDRE L.; CAPURRO GUIMARAES, MARGARETH DE LARA; TANAKA, APARECIDA SADAE. Functional characterization of a serine protease inhibitor modulated in the infection of the Aedes aegypti with dengue virus. Biochimie, v. 144, p. 160-168, JAN 2018. Web of Science Citations: 4. (12/15191-3, 12/03657-8)
OLIVEIRA, FELIPE A. A.; BURI, MARCUS V.; RODRIGUEZ, BORIS L.; COSTA-DA-SILVA, ANDRE L.; ARAUJO, HELENA R. C.; CAPURRO, MARGARETH L.; LU, STEPHEN; TANAKA, APARECIDA S.. The first characterization of a cystatin and a cathepsin L-like peptidase from Aedes aegypti and their possible role in DENV infection by the modulation of apoptosis. International Journal of Biological Macromolecules, v. 146, p. 141-149, MAR 1 2020. Web of Science Citations: 0. (13/16609-4, 12/03657-8)
LU, S.; PARIZI, L. F.; TORQUATO, R. J. S.; VAZ JUNIOR, I. S.; TANAKA, A. S.. Novel pseudo-aspartic peptidase from the midgut of the tick Rhipicephalus microplus. SCIENTIFIC REPORTS, v. 9, JAN 24 2019. Web of Science Citations: 0. (15/09268-1, 12/03657-8)
SOARES, TATIANE SANCHES; SOARES TORQUATO, RICARDO JOSE; GONZALEZ, YAMILE GONZALEZ; ALVES LEMOS, FRANCISCO JOSE; TANAKA, APARECIDA SADAE. Production of serine protease inhibitors by mutagenesis and their effects on the mortality of Aedes aegypti L. larvae. PARASITES & VECTORS, v. 8, OCT 6 2015. Web of Science Citations: 1. (12/03657-8, 05/03514-9, 09/05405-3, 09/06003-6)
ANDREOTTI‚ R.; GOMES‚ A.; MALAVAZI-PIZA‚ K.C.; SASAKI‚ S.D.; SAMPAIO‚ C.A.M.; TANAKA‚ A.S.. BmTI antigens induce a bovine protective immune response against Boophilus microplus tick. International Immunopharmacology, v. 2, n. 4, p. 557-563, 2002.
AZZOLINI‚ S.S.; SANTOS‚ J.; SOUZA‚ A.F.; TORQUATO‚ R.J.S.; HIRATA‚ I.Y.; ANDREOTTI‚ R.; TANAKA‚ A.S.. Purification‚ characterization‚ and cloning of a serine proteinase inhibitor from the ectoparasite Haematobia irritans irritans(Diptera: Muscidae). Experimental Parasitology, v. 106, n. 3, p. 103-109, 2004.
DE MORAIS-ZANI, KAREN; GREGO, KATHLEEN F.; TORQUATO, RICARDO J. S.; SILVA, CAROLINE S.; TANAKA, APARECIDA S.; TANAKA-AZEVEDO, ANITA M.. Cloning, Characterization and Anti-Inflammatory Properties of Bothrops jararaca Snake Antithrombin. PROTEIN AND PEPTIDE LETTERS, v. 22, n. 5, p. 410-418, 2015. Web of Science Citations: 1. (11/21558-4, 09/53844-6, 09/03484-3)
BUARQUE, DIEGO S.; BRAZ, GLORIA R. C.; MARTINS, RAFAEL M.; TANAKA-AZEVEDO, ANITA M.; GOMES, CICERA M.; OLIVEIRA, FELIPE A. A.; SCHENKMAN, SERGIO; TANAKA, APARECIDA S.. Differential Expression Profiles in the Midgut of Triatoma infestans Infected with Trypanosoma cruzi. PLoS One, v. 8, n. 5, MAY 2 2013. Web of Science Citations: 14. (05/03514-9, 12/00723-0, 12/03657-8)
DE MARCO, RENATO; LOVATO, DIOGO V.; TORQUATO, RICARDO J. S.; CLARA, RENAN O.; BUARQUE, DIEGO S.; TANAKA, APARECIDA S.. The first pacifastin elastase inhibitor characterized from a blood sucking animal. Peptides, v. 31, n. 7, p. 1280-1286, JUL 2010. Web of Science Citations: 11. (05/03514-9)
LOVATO‚ D.V.; NICOLAU DE CAMPOS‚ I.T.; AMINO‚ R.; TANAKA‚ A.S.. The full-length cDNA of anticoagulant protein infestin revealed a novel releasable Kazal domain‚ a neutrophil elastase inhibitor lacking anticoagulant activity. Biochimie, v. 88, n. 6, p. 673-681, 2006.
MALAVAZI-PIZA‚ K.C.; ARAÚJO‚ M.S.; GODINHO‚ R.O.; TANAKA‚ A.S.. Effect of invertebrate serine proteinase inhibitors on carrageenan-induced pleural exudation and bradykinin release. International Immunopharmacology, v. 4, n. 10, p. 1401-1408, 2004.
ABREU, PATRICIA A.; SOARES, TATIANE S.; BUARQUE, DIEGO S.; TORQUATO, RICARDO S.; TANAKA, APARECIDA S.. RmKK, a tissue kallikrein inhibitor from Rhipicephalus microplus eggs. Biochemical and Biophysical Research Communications, v. 449, n. 1, p. 69-73, JUN 20 2014. Web of Science Citations: 3. (05/03514-9, 12/03657-8)
WATANABE, RENATA M. O.; TANAKA-AZEVEDO, ANITA M.; ARAUJO, MARIANA S.; JULIANO, MARIA A.; TANAKA, APARECIDA S.. Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type inhibitor from Aedes aegypti with anticoagulant activity. Biochimie, v. 93, n. 3, p. 618-623, 2011. Web of Science Citations: 13. (05/03514-9)
SASAKI‚ S. D.; AZZOLINI‚ S. S. A.; HIRATA‚ I. Y.; ANDREOTTI‚ R.; TANAKA‚ A. S.. Boophilus microplus tick larvae‚ a rich source of Kunitz type serine proteinase inhibitors. Biochimie, v. 86, n. 9/10, p. 643-649, Sept.-Oct. 2004.
SOARES, TATIANE SANCHES; SOARES TORQUATO, RICARDO JOSE; ALVES LEMOS, FRANCISCO JOSE; TANAKA, APARECIDA SADAE. Selective inhibitors of digestive enzymes from Aedes aegypti larvae identified by phage display. Insect Biochemistry and Molecular Biology, v. 43, n. 1, p. 9-16, JAN 2013. Web of Science Citations: 5. (05/03514-9, 09/05405-3)
BUARQUE, DIEGO S.; SPINDOLA, LETICIA M. N.; MARTINS, RAFAEL M.; BRAZ, GLORIA R. C.; TANAKA, APARECIDA S.. Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruzi. Biochemical and Biophysical Research Communications, v. 413, n. 2, p. 241-247, SEP 23 2011. Web of Science Citations: 9. (05/03514-9)
WATANABE, RENATA M. O.; SOARES, TATIANE S.; MORAIS-ZANI, KAREN; TANAKA-AZEVEDO, ANITA M.; MACIEL, CERES; CAPURRO, MARGARETH L.; TORQUATO, RICARDO J. S.; TANAKA, APARECIDA S.. A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity. Biochimie, v. 92, n. 8, p. 933-939, AUG 2010. Web of Science Citations: 20. (05/03514-9)
SOARES‚ T.S.; WATANABE‚ R.M.O.; LEMOS‚ F.J.A.; TANAKA‚ A.S.. Molecular characterization of genes encoding trypsin-like enzymes from< i> Aedes aegypti larvae and identification of digestive enzymes. GENESIS, v. 489, n. 2, p. 70-75, 2011. (05/03514-9)
SOARES, TATIANE S.; WATANABE, RENATA M. O.; LEMOS, FRANCISCO J. A.; TANAKA, APARECIDA S.. Molecular characterization of genes encoding trypsin-like enzymes from Aedes aegypti larvae and identification of digestive enzymes. Gene, v. 489, n. 2, p. 70-75, DEC 10 2011. Web of Science Citations: 18. (05/03514-9)
USO DE INIBIDORES DE PROTEASES ISOLADOS DO TRIATOMA INFESTANS PI0602496-3 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade Federal de São Paulo (UNIFESP). Ivan Torres Nicolau de Campos; Aparecida Sadae Tanaka - July 2006, 03