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Aparecida Sadae Tanaka

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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

graduate at Quimica from Universidade Estadual Paulista Júlio de Mesquita Filho (1984), master's at Biochemistry from Universidade Federal de São Paulo (1991) and Ph.D. at Biochemistry from Universidade Federal de São Paulo (1993). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: insects, ticks, R. microplus, proteinase inhibitor, proteases, phage display, transcriptome, vector-parasite interations. (Source: Lattes Curriculum)

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Scholarships abroad
FAPESP support in numbers * Updated April 03, 2021
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Most frequent collaborators in research granted by FAPESP
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Use this Research Supported by FAPESP (BV/FAPESP) channel only to send messages referring to FAPESP-funded scientific projects.


 

 

 

 

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (40)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications29
Citations215
Cit./Article7.4
Data from Web of Science

LU, STEPHEN; DA ROCHA, LETICIA A.; TORQUATO, RICARDO J. S.; VAZ JUNIOR, ITABAJARA DA SILVA; FLORIN-CHRISTENSEN, MONICA; TANAKA, APARECIDA S.. A novel type 1 cystatin involved in the regulation of Rhipicephalus microplus midgut cysteine proteases. TICKS AND TICK-BORNE DISEASES, v. 11, n. 3, . Web of Science Citations: 0. (15/09268-1, 12/03657-8, 17/25609-9)

GOMES, CICERA MARIA; DE MORAIS-ZANI, KAREN; LU, STEPHEN; BUARQUE, DIEGO DE SOUZA; CARDOSO BRAZ, GLORIA REGINA; GREGO, KATHLEEN FERNANDES; TANAKA, APARECIDA SADAE; TANAKA-AZEVEDO, ANITA MITICO. Differential transcript profile of inhibitors with potential anti-venom role in the liver of juvenile and adult Bothrops jararaca snake. PeerJ, v. 5, . Web of Science Citations: 2. (13/05357-4, 14/11108-0, 12/03657-8)

BUARQUE, DIEGO S.; GOMES, CICERA M.; ARAUJO, RICARDO N.; PEREIRA, MARCOS H.; FERREIRA, ROBERTA C.; GUARNERI, ALESSANDRA A.; TANAKA, APARECIDA S.. A new antimicrobial protein from the anterior midgut of Triatoma infestans mediates Trypanosoma cruzi establishment by controlling the microbiota. Biochimie, v. 123, p. 138-143, . Web of Science Citations: 6. (12/00723-0, 12/03657-8)

SOARES, TATIANE S.; BUARQUE, DIEGO S.; QUEIROZ, BRUNA R.; GOMES, CICERA M.; BRAZ, GLORIA R. C.; ARAUJO, RICARDO N.; PEREIRA, MARCOS H.; GUARNERI, ALESSANDRA A.; TANAKA, APARECIDA S.. A Kazal-type inhibitor is modulated by Trypanosoma cruzi to control microbiota inside the anterior midgut of Rhodnius prolixus. Biochimie, v. 112, p. 41-48, . Web of Science Citations: 13. (12/00723-0, 12/03657-8)

LU, STEPHEN; SOARES, TATIANE S.; VAZ JUNIOR, ITABAJARA S.; LOVATO, DIOGO V.; TANAKA, APARECIDA S.. Rmcystatin3, a cysteine protease inhibitor from Rhipicephalus microplus hemocytes involved in immune response. Biochimie, v. 106, p. 17-23, . Web of Science Citations: 7. (05/03514-9, 09/17589-1, 12/03657-8)

CAMPOS, I. T. N.; SOUZA, T. A. C. B.; TORQUATO, R. J. S.; DE MARCO, R.; TANAKA-AZEVEDO, A. M.; TANAKA, A. S.; BARBOSA, J. A. R. G.. The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v. 68, n. 6, p. 695-702, . Web of Science Citations: 16. (01/07535-0, 05/03514-9)

DE MARCO, RENATO; AZZOLINI, SIMONE S.; LOVATO, DIOGO V.; TORQUATO, RICARDO J. S.; AMINO, ROGERIO; DE MIRANDA, ANTONIO; TANAKA, APARECIDA S.. Validation of a Phage Display Method for Protease Inhibitor Selection Using SFTI and HiTI Synthetic Hybrid Peptides. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, v. 13, n. 9, p. 829-835, . Web of Science Citations: 2. (05/03514-9)

LOVATO‚ D.V.; NICOLAU DE CAMPOS‚ I.T.; AMINO‚ R.; TANAKA‚ A.S.. The full-length cDNA of anticoagulant protein infestin revealed a novel releasable Kazal domain‚ a neutrophil elastase inhibitor lacking anticoagulant activity. Biochimie, v. 88, n. 6, p. 673-681, .

MALAVAZI-PIZA‚ K.C.; ARAÚJO‚ M.S.; GODINHO‚ R.O.; TANAKA‚ A.S.. Effect of invertebrate serine proteinase inhibitors on carrageenan-induced pleural exudation and bradykinin release. International Immunopharmacology, v. 4, n. 10, p. 1401-1408, .

ABREU, PATRICIA A.; SOARES, TATIANE S.; BUARQUE, DIEGO S.; TORQUATO, RICARDO S.; TANAKA, APARECIDA S.. RmKK, a tissue kallikrein inhibitor from Rhipicephalus microplus eggs. Biochemical and Biophysical Research Communications, v. 449, n. 1, p. 69-73, . Web of Science Citations: 3. (05/03514-9, 12/03657-8)

WATANABE, RENATA M. O.; TANAKA-AZEVEDO, ANITA M.; ARAUJO, MARIANA S.; JULIANO, MARIA A.; TANAKA, APARECIDA S.. Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type inhibitor from Aedes aegypti with anticoagulant activity. Biochimie, v. 93, n. 3, p. 618-623, . Web of Science Citations: 13. (05/03514-9)

SASAKI‚ S. D.; AZZOLINI‚ S. S. A.; HIRATA‚ I. Y.; ANDREOTTI‚ R.; TANAKA‚ A. S.. Boophilus microplus tick larvae‚ a rich source of Kunitz type serine proteinase inhibitors. Biochimie, v. 86, n. 9/10, p. 643-649, .

SOARES, TATIANE SANCHES; SOARES TORQUATO, RICARDO JOSE; ALVES LEMOS, FRANCISCO JOSE; TANAKA, APARECIDA SADAE. Selective inhibitors of digestive enzymes from Aedes aegypti larvae identified by phage display. Insect Biochemistry and Molecular Biology, v. 43, n. 1, p. 9-16, . Web of Science Citations: 5. (05/03514-9, 09/05405-3)

BUARQUE, DIEGO S.; SPINDOLA, LETICIA M. N.; MARTINS, RAFAEL M.; BRAZ, GLORIA R. C.; TANAKA, APARECIDA S.. Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruzi. Biochemical and Biophysical Research Communications, v. 413, n. 2, p. 241-247, . Web of Science Citations: 9. (05/03514-9)

WATANABE, RENATA M. O.; SOARES, TATIANE S.; MORAIS-ZANI, KAREN; TANAKA-AZEVEDO, ANITA M.; MACIEL, CERES; CAPURRO, MARGARETH L.; TORQUATO, RICARDO J. S.; TANAKA, APARECIDA S.. A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity. Biochimie, v. 92, n. 8, p. 933-939, . Web of Science Citations: 20. (05/03514-9)

SOARES‚ T.S.; WATANABE‚ R.M.O.; LEMOS‚ F.J.A.; TANAKA‚ A.S.. Molecular characterization of genes encoding trypsin-like enzymes from< i> Aedes aegypti larvae and identification of digestive enzymes. GENESIS, v. 489, n. 2, p. 70-75, . (05/03514-9)

SOARES, TATIANE S.; WATANABE, RENATA M. O.; LEMOS, FRANCISCO J. A.; TANAKA, APARECIDA S.. Molecular characterization of genes encoding trypsin-like enzymes from Aedes aegypti larvae and identification of digestive enzymes. Gene, v. 489, n. 2, p. 70-75, . Web of Science Citations: 18. (05/03514-9)

KARLA A. OLIVEIRA; RICARDO J. S. TORQUATO; DANIELA C. G. GARCIA LUSTOSA; TALES RIBEIRO; BRUNO W. L. NASCIMENTO; LILIAN C. G. DE OLIVEIRA; MARIA A. JULIANO; THAYSA PASCHOALIN; VIRGINIA S. LEMOS; RICARDO N. ARAUJO; et al. Proteolytic activity of Triatoma infestans saliva associated with PAR-2 activation and vasodilation. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, p. -, . Web of Science Citations: 0. (12/03657-8)

SOARES, TATIANE S.; OLIVEIRA, FELIPE; TORQUATO, RICARDO J. S.; SASAKI, SERGIO D.; ARAUJO, MARIANA S.; PASCHOALIN, THAYSA; TANAKA, APARECIDA S.. BmTI-A, a Kunitz type inhibitor from Rhipicephalus microplus able to interfere in vessel formation. Veterinary Parasitology, v. 219, p. 44-52, . Web of Science Citations: 7. (05/03514-9, 12/03657-8)

TORQUATO, RICARDO J. S.; LU, STEPHEN; MARTINS, NADIA HELENA; TANAKA, APARECIDA S.; BARBOSA PEREIRA, PEDRO JOSE. High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 73, n. 8, p. 469-475, . Web of Science Citations: 1. (12/03657-8)

CARDOSO, THYAGO H. S.; LU, STEPHEN; GONZALEZ, BORIS R. G.; TORQUATO, RICARDO J. S.; TANAKA, APARECIDA S.. Characterization of a novel cystatin type 2 from Rhipicephalus microplus midgut. Biochimie, v. 140, p. 117-121, . Web of Science Citations: 1. (11/09340-3, 12/03657-8)

SOARES, TATIANE SANCHES; RODRIGUEZ GONZALEZ, BORIS LUIS; SOARES TORQUATO, RICARDO JOSE; ALVES LEMOS, FRANCISCO JOSE; COSTA-DA-SILVA, ANDRE L.; CAPURRO GUIMARAES, MARGARETH DE LARA; TANAKA, APARECIDA SADAE. Functional characterization of a serine protease inhibitor modulated in the infection of the Aedes aegypti with dengue virus. Biochimie, v. 144, p. 160-168, . Web of Science Citations: 4. (12/15191-3, 12/03657-8)

OLIVEIRA, FELIPE A. A.; BURI, MARCUS V.; RODRIGUEZ, BORIS L.; COSTA-DA-SILVA, ANDRE L.; ARAUJO, HELENA R. C.; CAPURRO, MARGARETH L.; LU, STEPHEN; TANAKA, APARECIDA S.. The first characterization of a cystatin and a cathepsin L-like peptidase from Aedes aegypti and their possible role in DENV infection by the modulation of apoptosis. International Journal of Biological Macromolecules, v. 146, p. 141-149, . Web of Science Citations: 0. (13/16609-4, 12/03657-8)

LU, S.; PARIZI, L. F.; TORQUATO, R. J. S.; VAZ JUNIOR, I. S.; TANAKA, A. S.. Novel pseudo-aspartic peptidase from the midgut of the tick Rhipicephalus microplus. SCIENTIFIC REPORTS, v. 9, . Web of Science Citations: 0. (15/09268-1, 12/03657-8)

SOARES, TATIANE SANCHES; SOARES TORQUATO, RICARDO JOSE; GONZALEZ, YAMILE GONZALEZ; ALVES LEMOS, FRANCISCO JOSE; TANAKA, APARECIDA SADAE. Production of serine protease inhibitors by mutagenesis and their effects on the mortality of Aedes aegypti L. larvae. PARASITES & VECTORS, v. 8, . Web of Science Citations: 1. (12/03657-8, 05/03514-9, 09/05405-3, 09/06003-6)

ANDREOTTI‚ R.; GOMES‚ A.; MALAVAZI-PIZA‚ K.C.; SASAKI‚ S.D.; SAMPAIO‚ C.A.M.; TANAKA‚ A.S.. BmTI antigens induce a bovine protective immune response against Boophilus microplus tick. International Immunopharmacology, v. 2, n. 4, p. 557-563, .

AZZOLINI‚ S.S.; SANTOS‚ J.; SOUZA‚ A.F.; TORQUATO‚ R.J.S.; HIRATA‚ I.Y.; ANDREOTTI‚ R.; TANAKA‚ A.S.. Purification‚ characterization‚ and cloning of a serine proteinase inhibitor from the ectoparasite Haematobia irritans irritans(Diptera: Muscidae). Experimental Parasitology, v. 106, n. 3, p. 103-109, .

DE MORAIS-ZANI, KAREN; GREGO, KATHLEEN F.; TORQUATO, RICARDO J. S.; SILVA, CAROLINE S.; TANAKA, APARECIDA S.; TANAKA-AZEVEDO, ANITA M.. Cloning, Characterization and Anti-Inflammatory Properties of Bothrops jararaca Snake Antithrombin. PROTEIN AND PEPTIDE LETTERS, v. 22, n. 5, p. 410-418, . Web of Science Citations: 1. (11/21558-4, 09/53844-6, 09/03484-3)

BUARQUE, DIEGO S.; BRAZ, GLORIA R. C.; MARTINS, RAFAEL M.; TANAKA-AZEVEDO, ANITA M.; GOMES, CICERA M.; OLIVEIRA, FELIPE A. A.; SCHENKMAN, SERGIO; TANAKA, APARECIDA S.. Differential Expression Profiles in the Midgut of Triatoma infestans Infected with Trypanosoma cruzi. PLoS One, v. 8, n. 5, . Web of Science Citations: 14. (05/03514-9, 12/00723-0, 12/03657-8)

DE MARCO, RENATO; LOVATO, DIOGO V.; TORQUATO, RICARDO J. S.; CLARA, RENAN O.; BUARQUE, DIEGO S.; TANAKA, APARECIDA S.. The first pacifastin elastase inhibitor characterized from a blood sucking animal. Peptides, v. 31, n. 7, p. 1280-1286, . Web of Science Citations: 11. (05/03514-9)

LOVATO‚ D.V.; NICOLAU DE CAMPOS‚ I.T.; AMINO‚ R.; TANAKA‚ A.S.. The full-length cDNA of anticoagulant protein infestin revealed a novel releasable Kazal domain‚ a neutrophil elastase inhibitor lacking anticoagulant activity. Biochimie, v. 88, n. 6, p. 673-681, .

MALAVAZI-PIZA‚ K.C.; ARAÚJO‚ M.S.; GODINHO‚ R.O.; TANAKA‚ A.S.. Effect of invertebrate serine proteinase inhibitors on carrageenan-induced pleural exudation and bradykinin release. International Immunopharmacology, v. 4, n. 10, p. 1401-1408, .

ABREU, PATRICIA A.; SOARES, TATIANE S.; BUARQUE, DIEGO S.; TORQUATO, RICARDO S.; TANAKA, APARECIDA S.. RmKK, a tissue kallikrein inhibitor from Rhipicephalus microplus eggs. Biochemical and Biophysical Research Communications, v. 449, n. 1, p. 69-73, . Web of Science Citations: 3. (05/03514-9, 12/03657-8)

WATANABE, RENATA M. O.; TANAKA-AZEVEDO, ANITA M.; ARAUJO, MARIANA S.; JULIANO, MARIA A.; TANAKA, APARECIDA S.. Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type inhibitor from Aedes aegypti with anticoagulant activity. Biochimie, v. 93, n. 3, p. 618-623, . Web of Science Citations: 13. (05/03514-9)

SASAKI‚ S. D.; AZZOLINI‚ S. S. A.; HIRATA‚ I. Y.; ANDREOTTI‚ R.; TANAKA‚ A. S.. Boophilus microplus tick larvae‚ a rich source of Kunitz type serine proteinase inhibitors. Biochimie, v. 86, n. 9/10, p. 643-649, .

SOARES, TATIANE SANCHES; SOARES TORQUATO, RICARDO JOSE; ALVES LEMOS, FRANCISCO JOSE; TANAKA, APARECIDA SADAE. Selective inhibitors of digestive enzymes from Aedes aegypti larvae identified by phage display. Insect Biochemistry and Molecular Biology, v. 43, n. 1, p. 9-16, . Web of Science Citations: 5. (05/03514-9, 09/05405-3)

BUARQUE, DIEGO S.; SPINDOLA, LETICIA M. N.; MARTINS, RAFAEL M.; BRAZ, GLORIA R. C.; TANAKA, APARECIDA S.. Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruzi. Biochemical and Biophysical Research Communications, v. 413, n. 2, p. 241-247, . Web of Science Citations: 9. (05/03514-9)

WATANABE, RENATA M. O.; SOARES, TATIANE S.; MORAIS-ZANI, KAREN; TANAKA-AZEVEDO, ANITA M.; MACIEL, CERES; CAPURRO, MARGARETH L.; TORQUATO, RICARDO J. S.; TANAKA, APARECIDA S.. A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity. Biochimie, v. 92, n. 8, p. 933-939, . Web of Science Citations: 20. (05/03514-9)

SOARES‚ T.S.; WATANABE‚ R.M.O.; LEMOS‚ F.J.A.; TANAKA‚ A.S.. Molecular characterization of genes encoding trypsin-like enzymes from< i> Aedes aegypti larvae and identification of digestive enzymes. GENESIS, v. 489, n. 2, p. 70-75, . (05/03514-9)

SOARES, TATIANE S.; WATANABE, RENATA M. O.; LEMOS, FRANCISCO J. A.; TANAKA, APARECIDA S.. Molecular characterization of genes encoding trypsin-like enzymes from Aedes aegypti larvae and identification of digestive enzymes. Gene, v. 489, n. 2, p. 70-75, . Web of Science Citations: 18. (05/03514-9)

Patent applications

USO DE INIBIDORES DE PROTEASES ISOLADOS DO TRIATOMA INFESTANS PI0602496-3 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade Federal de São Paulo (UNIFESP). Ivan Torres Nicolau de Campos; Aparecida Sadae Tanaka - July 2006, 03

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