CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Odontologia from Universidade de São Paulo (2003) and doctorate at Odontology from Universidade de São Paulo (2006). Has experience in Genetics, focusing on Animal Genetics, acting on the following subjects: carcinoma epidermóide, beta-catenina, ciclina d1, bucal and oral. (Source: Lattes Curriculum)
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Head and neck squamous cell carcinomas (HNSCC) are malignant neoplasia with a high incidence worldwide, which is about 890,000 people affected annually. Approximately 450,000 deaths in the world yearly are a consequence of this devastating disease. The treatment, however, still suffers significantly from no specificity. Proteases, in general, play a relevant role in the transformation and…
Head and neck squamous cell carcinoma (HNSCC), including carcinomas of the oral cavity (OSCC), remains a challenging cancer to treat with no improvement in survival rates over the past 50 years. Thus, there is an urgent need to discover more reliable therapeutic targets and biomarkers for this disease. Kallikrein 5 (KLK5) is a member of the tissue kallikrein family implicated in OSCC deve…
Cervical carcinoma has been treated, nowadays, as a public health issue because of its high incidence and mortality rates in Brazil and around the world. In most cases, these carcinomas are caused due to the integration of human virus papilloma (HPV) oncogenes into the DNA of cervical epithelial cells, which leads them into a gradual malignant transformation to carcinoma. Among other fact…
Head and neck cancer (HNSCC) is the sixth most common cancer worldwide, with an estimated burden of approximately 500,000 cases/year. Matriptase, a protease belonging to the type II transmembrane serine proteases (TTSPs), is unique among tumor-associated proteases in that epithelial stem cell expression suffices to induce malignant transformation. It has been recently shown that PI3K-Akt-…
Oral squamous cell carcinoma, originating from the epithelial lining cells of the head and neck, is a major global public health problem. Late diagnosis implies a poor prognosis, with a 5-year survival rate of 50% and aggressive treatment options. Understanding that early diagnosis significantly improves the disease treatment scenario increases survival rates. It enhances patients' qualit…
Recent global estimates indicate that lip and oral cavity cancers collectively represent the 16th most common neoplasm worldwide, with approximately 355,000 new cases per year. In Brazil, oral cancer ranks eighth, with an estimated 15,100 new cases and 6,000 deaths annually. The treatment of this pathology has not improved significantly for almost 50 years, and cisplatin is still the most…
Head and neck carcinoma (HNSCC) is a neoplasm with a high incidence rate and aggressiveness, however, the forms of treatment have little specificity, using the same chemotherapy agents for over 50 years. Matriptase is a type II transmembrane serine protease (TTSP), which plays a crucial role in maintaining the physiological functions of epithelial tissues. However, its expression is incre…
Oral cancer is a public health issue and it is a consequence of a few habits i.e., alcoholism and smoking, in addition to pathogens such as HPV. Brazil has one of the highest mortality rates in the world and it is mainly due to late diagnosis of this disease. Proteolytic enzymes, including kallikrein 14 (KLK14), are related to tumor growth and development, as these proteins have a role in…
(Only some records are available in English at this moment)
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Matriptase, a type II transmembrane serine protease, induces malignant transformation through proteolytic activation of pro-HGF and PAR-2, which leads to activation of PI3K-AKT-mTOR and NFºB signaling, respectively, in epithelial stem cells. Lympho-Epithelial Kazal-Type-related Inhibitor (LEKTI) was s…
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 15 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 21 / 17 | All research grants and scholarships |
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