CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Odontologia from Universidade de São Paulo (2003) and doctorate at Odontology from Universidade de São Paulo (2006). Has experience in Genetics, focusing on Animal Genetics, acting on the following subjects: carcinoma epidermóide, beta-catenina, ciclina d1, bucal and oral. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
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Cervical carcinoma has been treated, nowadays, as a public health issue because of its high incidence and mortality rates in Brazil and around the world. In most cases, these carcinomas are caused due to the integration of human virus papilloma (HPV) oncogenes into the DNA of cervical epithelial cells, which leads them into a gradual malignant transformation to carcinoma. Among other fact…
Head and neck cancer (HNSCC) is the sixth most common cancer worldwide, with an estimated burden of approximately 500,000 cases/year. Matriptase, a protease belonging to the type II transmembrane serine proteases (TTSPs), is unique among tumor-associated proteases in that epithelial stem cell expression suffices to induce malignant transformation. It has been recently shown that PI3K-Akt-…
Cervical carcinoma has a high incidence in Brazil and worldwide. Currently, despite all the advances in the area and, due to its prevalence and severity, this condition is considered a public health problem. In 2018 alone, the National Cancer Institute (INCA) estimated 16,370 new cases of this disease in Brazil. This carcinoma develops by integrating Human Papillomavirus (HPV) oncogenes i…
The serine protease TMPRSS11A (DESC3), belonging to the newly discovered family HAT / DESC serine transmembrane protease type II (TTSPII) is deleted / mutated in, respectively, 4% of cervical cancers and 2% of cancers mouth (obtained cBioPortal database). However, little is known about this enzyme. However, in John P. Hobson et al. (JBC Papers, 2004) observed that the serine protease TMPR…
Head and neck cancer comprises predominantly squamous cell carcinomas and affects the oral cavity, larynx, and pharynx. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with 550.000 new cases every year. Matriptase, a type II transmembrane serine protease, induces malignant transformation when expressed in epithelial stem cells. It has been recently …
(Only some records are available in English at this moment)
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Matriptase, a type II transmembrane serine protease, induces malignant transformation through proteolytic activation of pro-HGF and PAR-2, which leads to activation of PI3K-AKT-mTOR and NFºB signaling, respectively, in epithelial stem cells. Lympho-Epithelial Kazal-Type-related Inhibitor (LEKTI) was s…
| 2 / 2 | Completed research grants |
| 11 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 14 / 10 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 13 |
| Cit./Article | 4.3 |
| Data from Web of Science | |
ALVES, MARCIA GAIAO; KODAMA, MARCIO HIDEKI; MARCELINO DA SILVA, ELAINE ZAYAS; MARTINELLI GOMES, BRUNO BELMONTE; ALVES DA SILVA, RODRIGO ALBERTO; VIEIRA, GABRIEL VILIOD; ALVES, VANI MARIA; DA FONSECA, CAROL KOBORI; SANTANA, ANA CAROLINA; CECILIO, NERRY TATIANA; et al. Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma. TRANSLATIONAL ONCOLOGY, v. 14, n. 1, JAN 2021. Web of Science Citations: 0. (16/16715-7, 16/13228-8, 14/06316-2)
SALES, K. U.; FRIIS, S.; ABUSLEME, L.; MOUTSOPOULOS, N. M.; BUGGE, T. H.. Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors. Oncogene, v. 34, n. 35, p. 4664-4672, AUG 27 2015. Web of Science Citations: 10. (14/14311-0)
SALES, K. U.; GIUDICE, F. S.; CASTILHO, R. M.; SALLES, F. T.; SQUARIZE, C. H.; ABRAHAO, A. C.; PINTO, JR., D. S.. Cyclin D1-induced proliferation is independent of beta-catenin in Head and Neck Cancer. ORAL DISEASES, v. 20, n. 3, p. e42-e48, APR 2014. Web of Science Citations: 3.
FREITAS FILHO, EDISMAURO G.; DA SILVA, ELAINE Z. M.; ONG, HWEI LING; SWAIM, WILLIAM D.; AMBUDKAR, INDU S.; OLIVER, CONSTANCE; JAMUR, MARIA CELIA. RACK1 plays a critical role in mast cell secretion and Ca2+ mobilization by modulating F-actin dynamics. Journal of Cell Science, v. 134, n. 9, MAY 2021. Web of Science Citations: 1. (17/14645-4, 09/54014-7, 17/18618-1, 15/16673-0, 16/13228-8, 16/21988-2, 09/54013-0)
(References retrieved automatically from State of São Paulo Research Institutions)
GOMES, Bruno Belmonte Martinelli. Modulação do fenótipo dependente do HPV16, pela expressão de HAI-1, em células-tronco epiteliais. Dissertação (Mestrado) - Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (16/16715-7)