graduation at Odontologia from Universidade de São Paulo (2003) and doctorate at Odontology from Universidade de São Paulo (2006). Has experience in Genetics, focusing on Animal Genetics, acting on the following subjects: carcinoma epidermóide, beta-catenina, ciclina d1, bucal and oral. (Source: Lattes Curriculum)
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Head and neck squamous cell carcinoma (HNSCC), including carcinomas of the oral cavity (OSCC), remains a challenging cancer to treat with no improvement in survival rates over the past 50 years. Thus, there is an urgent need to discover more reliable therapeutic targets and biomarkers for this disease. Kallikrein 5 (KLK5) is a member of the tissue kallikrein family implicated in OSCC deve…
Cervical carcinoma has been treated, nowadays, as a public health issue because of its high incidence and mortality rates in Brazil and around the world. In most cases, these carcinomas are caused due to the integration of human virus papilloma (HPV) oncogenes into the DNA of cervical epithelial cells, which leads them into a gradual malignant transformation to carcinoma. Among other fact…
Head and neck cancer (HNSCC) is the sixth most common cancer worldwide, with an estimated burden of approximately 500,000 cases/year. Matriptase, a protease belonging to the type II transmembrane serine proteases (TTSPs), is unique among tumor-associated proteases in that epithelial stem cell expression suffices to induce malignant transformation. It has been recently shown that PI3K-Akt-…
Head and neck squamous cell Carcinoma (HNSCC) is a type of Cancer with high incidence and is difficult to treat. Therefore, the discovery of new therapeutic targets for better treatments and, consequently, higher quality of life for these patients is needed. Kallikreins (KLKs) are serine proteases that have roles in both physiological and pathological processes, such as epithelial desquam…
Oral cancer is a public health issue and it is a consequence of a few habits i.e., alcoholism and smoking, in addition to pathogens such as HPV. Brazil has one of the highest mortality rates in the world and it is mainly due to late diagnosis of this disease. Proteolytic enzymes, including kallikrein 14 (KLK14), are related to tumor growth and development, as these proteins have a role in…
Cervical carcinoma has a high incidence in Brazil and worldwide. Currently, despite all the advances in the area and, due to its prevalence and severity, this condition is considered a public health problem. In 2018 alone, the National Cancer Institute (INCA) estimated 16,370 new cases of this disease in Brazil. This carcinoma develops by integrating Human Papillomavirus (HPV) oncogenes i…
The serine protease TMPRSS11A (DESC3), belonging to the newly discovered family HAT / DESC serine transmembrane protease type II (TTSPII) is deleted / mutated in, respectively, 4% of cervical cancers and 2% of cancers mouth (obtained cBioPortal database). However, little is known about this enzyme. However, in John P. Hobson et al. (JBC Papers, 2004) observed that the serine protease TMPR…
Head and neck squamous cell carcinoma (HNSCC) is ranked fifth most common neoplasia worldwide, accounting for 750,000 new cases per year. Despite all the scientific advances that happened in recent years, there is still no specific therapy for HNSCC. It has already been described that type II transmembrane serine proteases (TTSPII), such as matriptase, are essential for development and pr…
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Matriptase, a type II transmembrane serine protease, induces malignant transformation through proteolytic activation of pro-HGF and PAR-2, which leads to activation of PI3K-AKT-mTOR and NFºB signaling, respectively, in epithelial stem cells. Lympho-Epithelial Kazal-Type-related Inhibitor (LEKTI) was s…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 11 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 17 / 13 | All research grants and scholarships |
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CV Lattes
ORCID