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Shaker Chuck Farah

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Universidade de São Paulo (USP). Instituto de Química (IQ)  (Institutional affiliation for the last research proposal)
Birthplace: Israel

Graduated in Biochemsitry and Chemistry (1985) and received his Masters in Biochemistry (1988) at the University of Toronto. He received his PhD in Biochemistry from Universidade de São Paulo (1994) where he is now a Full Professor in the Department of Biochemistry. His research interests focus on understanding the structural basis of important biological and behavioral processes in bacteria using the phytopathogen Xanthomonas citri as a model. Specific systems under study are 1) signaling pathways involving the important second messenger cyclic diGMP that controls complex behaviours such as the production of virulence factors, motility and biofilm formation, 2) The structure and regulation of the type IV pilus, used by Xantthomonas to migrate across solid surfaces and to organize biofilm structures. 3) The Xanthomonas Type IV secretion system that mediates the transfer of bacterial toxins to the cells of other bacterial species, 4) Quorum sensing, the means by which members of a bacterial population coordinate their behavior in a manner dependent on cell density. His studies combine a variety of approaches including protein crystallography, Cryo-EM and NMR, other spectroscopic techniques, enzymology, fluorescence microscopy, the production and characterization of Xanthomonas knock-out strains and the analysis of protein interaction networks. (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher
Científicos develan cómo una bacteria oportunista derrota a sus competidoras 
La FAPESP selecciona 30 proyectos en su convocatoria de combate contra el nuevo coronavirus 
Investigadores brasileños desarrollan un test para diagnosticar el COVID-19 a través de la saliva 
Brazilian researchers develop saliva-based COVID-19 diagnostic test 
FAPESP selects 30 projects in call for research proposals to combat novel coronavirus 
Pesquisadores desvendam como bactéria oportunista derrota competidoras 
Researchers show how opportunistic bacterium defeats competitors 
Articles published in Pesquisa FAPESP Magazine about the researcher:
Lethal Contact 
Contacto letal 
Lethal Contact 
Articles published in other media outlets (21 total):
More itemsLess items
Jornal da USP online: Pesquisadores do Instituto de Ciências Biomédicas descobrem nova família de toxina bacteriana (03/Jul/2020)
Programa InfoSalud (Argentina): Científicos develan cómo una bacteria oportunista derrota a sus competidoras (30/Jan/2020)
Revista Ecológico online: Pesquisadores desvendam como bactéria oportunista derrota competidoras (17/Dec/2019)
Sou Ecológico: Pesquisadores desvendam como bactéria oportunista derrota competidoras (17/Dec/2019)
LabNetwork: Pesquisadores desvendam como bactéria oportunista derrota competidoras (12/Dec/2019)
Algomais online: Pesquisadores desvendam como bactéria oportunista derrota competidoras (12/Dec/2019)
Brasil CT&I: Pesquisadores desvendam como bactéria oportunista derrota competidoras (12/Dec/2019)
Portal Exame: Pesquisadores desvendam como bactéria oportunista derrota competidoras (11/Dec/2019)
MSN: Pesquisadores desvendam como bactéria oportunista derrota competidoras (11/Dec/2019)
Diário da Saúde: Bactéria contra bactéria pode render novos antibióticos (11/Dec/2019)
Confap - Conselho Nacional das Fundações Estaduais de Amparo à Pesquisa: Pesquisadores desvendam como bactéria oportunista derrota competidores (11/Dec/2019)
Esteta : Pesquisadores desvendam como bactéria oportunista derrota competidoras (11/Dec/2019)
Planeta online: Descoberto como bactéria oportunista de hospitais elimina oponentes (11/Dec/2019)
Jornal da Ciência online: Pesquisadores desvendam como bactéria oportunista derrota competidoras (11/Dec/2019)
Portal da Enfermagem: Pesquisadores desvendam como bactéria oportunista derrota competidoras (11/Dec/2019)
Programa InfoSalud (Argentina): Investigadores revelan como bacterias oportunistas derrotan a competidoras (11/Dec/2019)
Phys.Org (Reino Unido): Researchers show how opportunistic bacterium defeats competitors (10/Dec/2019)
Science Codex: Researchers show how opportunistic bacterium defeats competitors (10/Dec/2019)
Brightsurf: Researchers show how opportunistic bacterium defeats competitors (10/Dec/2019)
7thSpace: Researchers show how opportunistic bacterium defeats competitors (10/Dec/2019)
Long Room (EUA): Researchers show how opportunistic bacterium defeats competitors (12/Oct/2019)
Research grants
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Scholarships abroad
FAPESP support in numbers * Updated June 05, 2021
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (24)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications23
Citations194
Cit./Article8.4
Data from Web of Science

GUZZO, CRISTIANE R.; NAGEM, RONALDO A. P.; GALVÃO-BOTTON, LEONOR M. P.; GUIMARÃES, BEATRIZ G.; MEDRANO, FRANCISCO J.; BARBOSA, JOÃO A. R. G.; FARAH, SHAKER CHUCK. Expression, purification, crystallization and preliminary X-ray analysis of YaeQ (XAC2396) from Xanthomonas axonopodis pv. citri. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 61, n. 5, p. 493-495, .

CORREA, FERNANDO; SALINAS, ROBERTO KOPKE; BONVIN, ALEXANDRE M. J. J.; FARAH, CHUCK S.. Deciphering the role of the electrostatic interactions in the alpha-tropomyosin head-to-tail complex. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v. 73, n. 4, p. 902-917, . Web of Science Citations: 5. (05/59243-3)

SGRO, GERMAN G.; OKA, GABRIEL U.; SOUZA, DIORGE P.; CENENS, WILLIAM; BAYER-SANTOS, ETHEL; MATSUYAMA, BRUNO Y.; BUENO, NATALIA F.; DOS SANTOS, THIAGO RODRIGO; ALVAREZ-MARTINEZ, CRISTINA E.; SALINAS, ROBERTO K.; et al. Bacteria-Killing Type IV Secretion Systems. FRONTIERS IN MICROBIOLOGY, v. 10, . Web of Science Citations: 2. (18/01852-4, 17/02178-2, 17/17303-7)

BAYER-SANTOS, ETHEL; CESETI, LUCAS DE MORAES; FARAH, CHUCK SHAKER; ALVAREZ-MARTINEZ, CRISTINA ELISA. Distribution, Function and Regulation of Type 6 Secretion Systems of Xanthomonadales. FRONTIERS IN MICROBIOLOGY, v. 10, . Web of Science Citations: 0. (18/04553-8, 17/17303-7, 17/02178-2, 18/01852-4, 17/02318-9)

CENENS, WILLIAM; ANDRADE, MAXUEL O.; LLONTOP, EDGAR; ALVAREZ-MARTINEZ, CRISTINA E.; SGRO, GERMAN G.; FARAH, CHUCK S.. Bactericidal type IV secretion system homeostasis in Xanthomonas citri. PLOS PATHOGENS, v. 16, n. 5, . Web of Science Citations: 0. (19/12234-2, 15/18237-2, 14/04294-1, 17/17303-7, 11/07777-5)

GUZZO, CRISTIANE R.; DUNGER, GERMAN; SALINAS, ROBERTO KOPKE; FARAH, CHUCK S.. Structure of the PilZ-FimX(EAL)-c-di-GMP Complex Responsible for the Regulation of Bacterial Type IV Pilus Biogenesis. Journal of Molecular Biology, v. 425, n. 12, p. 2174-2197, . Web of Science Citations: 24. (09/14477-8, 11/07777-5, 11/22571-4)

OLIVEIRA, LUCIANA COUTINHO; SOUZA, DIORGE PAULO; OKA, GABRIEL UMAJI; LIMA, FILIPE DA SILVA; OLIVEIRA, RONALDO JUNIO; FAVARO, DENIZE CRISTINA; WIENK, HANS; BOELENS, ROLF; FARAH, CHUCK SHAKER; SALINAS, ROBERTO KOPKE. VirB7 and VirB9 Interactions Are Required for the Assembly and Antibacterial Activity of a Type IV Secretion System. Structure, v. 24, n. 10, p. 1707-1718, . Web of Science Citations: 3. (11/07777-5, 13/17883-2)

BAYER-SANTOS, ETHEL; MARINI, MARJORIE M.; DA SILVEIRA, JOSE F.. Non-coding RNAs in Host-Pathogen Interactions: Subversion of Mammalian Cell Functions by Protozoan Parasites. FRONTIERS IN MICROBIOLOGY, v. 8, . Web of Science Citations: 9. (15/25381-2, 11/51475-3)

BAYER-SANTOS, ETHEL; CENENS, WILLIAM; MATSUYAMA, BRUNO YASUI; OKA, GABRIEL UMAJI; DI SESSA, GIANCARLO; MININEL, IZABEL DEL VALLE; ALVES, TIAGO LUBIANA; FARAH, CHUCK SHAKER. The opportunistic pathogen Stenotrophomonas maltophilia utilizes a type IV secretion system for interbacterial killing. PLOS PATHOGENS, v. 15, n. 9, . Web of Science Citations: 1. (15/25381-2, 18/04553-8, 17/02178-2, 11/07777-5, 15/18237-2, 16/00458-5, 17/17303-7)

ANTUNES, VICTOR U.; LLONTOP, EDGAR E.; VASCONCELOS, FERNANDA N. DA COSTA; DE LOS SANTOS, YOSSEF LOPEZ; OLIVEIRA, RONALDO J.; LINCOPAN, NILTON; FARAH, CHUCK S.; DOUCET, NICOLAS; MITTERMAIER, ANTHONY; FAVARO, DENIZE C.. Importance of the beta 5-beta 6 Loop for the Structure, Catalytic Efficiency, and Stability of Carbapenem-Hydrolyzing Class D beta-Lactamase Subfamily OXA-143. BIOCHEMISTRY, v. 58, n. 34, p. 3604-3616, . Web of Science Citations: 0. (17/17303-7, 17/22822-3)

SOUZA, DIORGE P.; ANDRADE, MAXUEL O.; ALVAREZ-MARTINEZ, CRISTINA E.; ARANTES, GUILHERME M.; FARAH, CHUCK S.; SALINAS, ROBERTO K.. A Component of the Xanthomonadaceae Type IV Secretion System Combines a VirB7 Motif with a N0 Domain Found in Outer Membrane Transport Proteins. PLOS PATHOGENS, v. 7, n. 5, p. e1002031, . Web of Science Citations: 29. (05/59243-3)

CAPPELLETTI, PAOLA A.; DOS SANTOS, RAFAEL FREITAS; DO AMARAL, ALEXANDRE M.; HOMEM, RAFAEL AUGUSTO; SOUZA, THAIS DOS SANTOS; MACHADO, MARCOS A.; FARAH, CHUCK S.. Structure-Function Analysis of the HrpB2-HrcU Interaction in the Xanthomonas citri Type III Secretion System. PLoS One, v. 6, n. 3, p. e17614, . Web of Science Citations: 6. (05/59243-3)

BAYER-SANTOS, ETHEL; LIMA, LIDIA DOS PASSOS; CESETI, LUCAS DE MORAES; RATAGAMI, CAMILA YURI; DE SANTANA, ELIANE SILVA; DA SILVA, ALINE MARIA; FARAH, CHUCK SHAKER; ALVAREZ-MARTINEZ, CRISTINA ELISA. Xanthomonas citri T6SS mediates resistance to Dictyostelium predation and is regulated by an ECF sigma factor and cognate Ser/Thr kinase. ENVIRONMENTAL MICROBIOLOGY, v. 20, n. 4, SI, p. 1562-1575, . Web of Science Citations: 6. (15/25381-2, 11/07777-5, 14/19720-6, 16/08400-6, 14/25261-4)

TEIXEIRA, RAPHAEL D.; GUZZO, CRISTIANE R.; AREVALO, SANTIAGO JUSTO; ANDRADE, MAXUEL O.; ABRAHAO, JOSIELLE; DE SOUZA, ROBSON F.; FARAH, CHUCK S.. A bipartite periplasmic receptor-diguanylate cyclase pair (XAC2383-XAC2382) in the bacterium Xanthomonas citri. Journal of Biological Chemistry, v. 293, n. 27, p. 10767-10781, . Web of Science Citations: 0. (11/07777-5)

SGRO, GERMAN G.; COSTA, TIAGO R. D.; CENENS, WILLIAM; SOUZA, DIORGE P.; CASSAGO, ALEXANDRE; DE OLIVEIRA, LUCIANA COUTINHO; SALINAS, ROBERTO K.; PORTUGAL, V, RODRIGO; FARAH, CHUCK S.; WAKSMAN, GABRIEL. Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. NATURE MICROBIOLOGY, v. 3, n. 12, p. 1429-1440, . Web of Science Citations: 11. (11/07777-5, 17/17303-7)

CESETI, LUCAS M.; DE SANTANA, ELIANE S.; RATAGAMI, CAMILA Y.; BARREIROS, YASMIN; LIMA, LIDIA DOS PASSOS; DUNGER, GERMAN; FARAH, CHUCK S.; ALVAREZ-MARTINEZ, CRISTINA E.. The Xanthomonas citri pv. citri Type VI Secretion System is Induced During Epiphytic Colonization of Citrus. Current Microbiology, v. 76, n. 10, p. 1105-1111, . Web of Science Citations: 0. (11/22571-4, 16/08400-6, 14/19720-6, 17/02318-9, 18/01852-4, 14/25261-4, 11/07777-5)

SIBINELLI-SOUSA, STEPHANIE; HESPANHOL, JULIA T.; NICASTRO, GIANLUCCA G.; MATSUYAMA, BRUNO Y.; MESNAGE, STEPHANE; PATEL, ANKUR; DE SOUZA, ROBSON F.; GUZZO, CRISTIANE R.; BAYER-SANTOS, ETHEL. A Family of T6SS Antibacterial Effectors Related to L,D-Transpeptidases Targets the Peptidoglycan. CELL REPORTS, v. 31, n. 12, . Web of Science Citations: 0. (18/04553-8, 17/02178-2, 16/09047-8, 19/00195-2, 17/17303-7, 18/25316-4, 16/00458-5, 18/13819-1)

OLIVEIRA, MAYCON C.; TEIXEIRA, RAPHAEL D.; ANDRADE, MAXUEL O.; PINHEIRO, GLAUCIA M. S.; RAMOS, CARLOS H. I.; FARAH, CHUCK S.. Cooperative Substrate Binding by a Diguanylate Cyclase. Journal of Molecular Biology, v. 427, n. 2, p. 415-432, . Web of Science Citations: 10. (11/07777-5)

DUNGER, GERMAN; GAROFALO, CECILIA G.; GOTTIG, NATALIA; GARAVAGLIA, BETIANA S.; PEREDA ROSA, MARIA C.; FARAH, CHUCK S.; ORELLANO, ELENA G.; OTTADO, JORGELINA. Analysis of three Xanthomonas axonopodis pv. citri effector proteins in pathogenicity and their interactions with host plant proteins. MOLECULAR PLANT PATHOLOGY, v. 13, n. 8, p. 865-876, . Web of Science Citations: 13. (05/59243-3)

SOUZA, DIORGE P.; OKA, GABRIEL U.; ALVAREZ-MARTINEZ, CRISTINA E.; BISSON-FILHO, ALEXANDRE W.; DUNGER, GERMAN; HOBEIKA, LISE; CAVALCANTE, NAYARA S.; ALEGRIA, MARCOS C.; BARBOSA, LEANDRO R. S.; SALINAS, ROBERTO K.; et al. Bacterial killing via a type IV secretion system. NATURE COMMUNICATIONS, v. 6, . Web of Science Citations: 40. (09/54009-3, 05/59243-3, 11/07777-5)

BAYER-SANTOS, ETHEL; LIMA, LIDIA DOS PASSOS; CESETI, LUCAS DE MORAES; RATAGAMI, CAMILA YURI; DE SANTANA, ELIANE SILVA; DA SILVA, ALINE MARIA; FARAH, CHUCK SHAKER; ALVAREZ-MARTINEZ, CRISTINA ELISA. Xanthomonas citri T6SS mediates resistance to Dictyostelium predation and is regulated by an ECF sigma factor and cognate Ser/Thr kinase. ENVIRONMENTAL MICROBIOLOGY, v. 20, n. 4, SI, p. 1562-1575, . Web of Science Citations: 6. (15/25381-2, 14/19720-6, 11/07777-5, 16/08400-6, 14/25261-4)

SGRO, GERMAN G.; COSTA, TIAGO R. D.; CENENS, WILLIAM; SOUZA, DIORGE P.; CASSAGO, ALEXANDRE; DE OLIVEIRA, LUCIANA COUTINHO; SALINAS, ROBERTO K.; PORTUGAL, V, RODRIGO; FARAH, CHUCK S.; WAKSMAN, GABRIEL. Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. NATURE MICROBIOLOGY, v. 3, n. 12, p. 1429-1440, . Web of Science Citations: 11. (11/07777-5, 17/17303-7)

CESETI, LUCAS M.; DE SANTANA, ELIANE S.; RATAGAMI, CAMILA Y.; BARREIROS, YASMIN; LIMA, LIDIA DOS PASSOS; DUNGER, GERMAN; FARAH, CHUCK S.; ALVAREZ-MARTINEZ, CRISTINA E.. The Xanthomonas citri pv. citri Type VI Secretion System is Induced During Epiphytic Colonization of Citrus. Current Microbiology, v. 76, n. 10, p. 1105-1111, . Web of Science Citations: 0. (11/22571-4, 16/08400-6, 14/19720-6, 17/02318-9, 18/01852-4, 14/25261-4, 11/07777-5)

JUSTO AREVALO, SANTIAGO; ZAPATA SIFUENTES, DANIELA; HUALLPA, CESAR J.; LANDA BIANCHI, GIANFRANCO; CASTILLO CHAVEZ, ADRIANA; GARAVITO-SALINI CASAS, ROMINA; UCEDA-CAMPOS, GUILLERMO; PINEDA CHAVARRIA, ROBERTO. Global Geographic and Temporal Analysis of SARS-CoV-2 Haplotypes Normalized by COVID-19 Cases During the Pandemic. FRONTIERS IN MICROBIOLOGY, v. 12, . Web of Science Citations: 0. (15/13318-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALEGRIA, Marcos Castanheira. Identificação de interações proteína-proteína envolvendo os produtos dos Loci hrp, vir e rpf de Xanthomonas axonopodis pv. citri.  215 f. Tese (Doutorado) -  Instituto de Química.  Universidade de São Paulo (USP).  São Paulo.  (98/15371-2

FERREIRA, Aurea Denise de Sousa Soller. Tropomiosinas contendo 5-hidroxitriptofano: sondas específicas para interações no filamento fino.  131 f. Tese (Doutorado) -  Instituto de Química.  Universidade de São Paulo (USP).  São Paulo.  (00/00686-0

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