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Shaker Chuck Farah

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Universidade de São Paulo (USP). Instituto de Química (IQ)  (Institutional affiliation for the last research proposal)
Birthplace: Israel

Graduated in Biochemsitry and Chemistry (1985) and received his Masters in Biochemistry (1988) at the University of Toronto. He received his PhD in Biochemistry from Universidade de São Paulo (1994) where he is now a Full Professor in the Department of Biochemistry. His research interests focus on understanding the structural basis of important biological and behavioral processes in bacteria using the phytopathogen Xanthomonas citri as a model. Specific systems under study are 1) signaling pathways involving the important second messenger cyclic diGMP that controls complex behaviours such as the production of virulence factors, motility and biofilm formation, 2) The structure and regulation of the type IV pilus, used by Xantthomonas to migrate across solid surfaces and to organize biofilm structures. 3) The Xanthomonas Type IV secretion system that mediates the transfer of bacterial toxins to the cells of other bacterial species, 4) Quorum sensing, the means by which members of a bacterial population coordinate their behavior in a manner dependent on cell density. His studies combine a variety of approaches including protein crystallography, Cryo-EM and NMR, other spectroscopic techniques, enzymology, fluorescence microscopy, the production and characterization of Xanthomonas knock-out strains and the analysis of protein interaction networks. (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated September 21, 2019
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (20)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications19
Citations200
Cit./Article10.5
Data from Web of Science

DUNGER, GERMAN; GAROFALO, CECILIA G.; GOTTIG, NATALIA; GARAVAGLIA, BETIANA S.; PEREDA ROSA, MARIA C.; FARAH, CHUCK S.; ORELLANO, ELENA G.; OTTADO, JORGELINA. Analysis of three Xanthomonas axonopodis pv. citri effector proteins in pathogenicity and their interactions with host plant proteins. MOLECULAR PLANT PATHOLOGY, v. 13, n. 8, p. 865-876, . Web of Science Citations: 13. (05/59243-3)

CAPPELLETTI, PAOLA A.; DOS SANTOS, RAFAEL FREITAS; DO AMARAL, ALEXANDRE M.; HOMEM, RAFAEL AUGUSTO; SOUZA, THAIS DOS SANTOS; MACHADO, MARCOS A.; FARAH, CHUCK S.. Structure-Function Analysis of the HrpB2-HrcU Interaction in the Xanthomonas citri Type III Secretion System. PLoS One, v. 6, n. 3, p. e17614, . Web of Science Citations: 7. (05/59243-3)

GUZZO, CRISTIANE R.; NAGEM, RONALDO A. P.; GALVÃO-BOTTON, LEONOR M. P.; GUIMARÃES, BEATRIZ G.; MEDRANO, FRANCISCO J.; BARBOSA, JOÃO A. R. G.; FARAH, SHAKER CHUCK. Expression, purification, crystallization and preliminary X-ray analysis of YaeQ (XAC2396) from Xanthomonas axonopodis pv. citri. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 61, n. 5, p. 493-495, .

CORREA, FERNANDO; SALINAS, ROBERTO KOPKE; BONVIN, ALEXANDRE M. J. J.; FARAH, CHUCK S.. Deciphering the role of the electrostatic interactions in the alpha-tropomyosin head-to-tail complex. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v. 73, n. 4, p. 902-917, . Web of Science Citations: 5. (05/59243-3)

TEIXEIRA, RAPHAEL D.; GUZZO, CRISTIANE R.; AREVALO, SANTIAGO JUSTO; ANDRADE, MAXUEL O.; ABRAHAO, JOSIELLE; DE SOUZA, ROBSON F.; FARAH, CHUCK S.. A bipartite periplasmic receptor-diguanylate cyclase pair (XAC2383-XAC2382) in the bacterium Xanthomonas citri. Journal of Biological Chemistry, v. 293, n. 27, p. 10767-10781, . Web of Science Citations: 0. (11/07777-5)

BAYER-SANTOS, ETHEL; CESETI, LUCAS DE MORAES; FARAH, CHUCK SHAKER; ALVAREZ-MARTINEZ, CRISTINA ELISA. Distribution, Function and Regulation of Type 6 Secretion Systems of Xanthomonadales. FRONTIERS IN MICROBIOLOGY, v. 10, . Web of Science Citations: 0. (18/04553-8, 17/17303-7, 17/02178-2, 18/01852-4, 17/02318-9)

BAYER-SANTOS, ETHEL; LIMA, LIDIA DOS PASSOS; CESETI, LUCAS DE MORAES; RATAGAMI, CAMILA YURI; DE SANTANA, ELIANE SILVA; DA SILVA, ALINE MARIA; FARAH, CHUCK SHAKER; ALVAREZ-MARTINEZ, CRISTINA ELISA. Xanthomonas citri T6SS mediates resistance to Dictyostelium predation and is regulated by an ECF sigma factor and cognate Ser/Thr kinase. ENVIRONMENTAL MICROBIOLOGY, v. 20, n. 4, SI, p. 1562-1575, . Web of Science Citations: 4. (16/08400-6, 14/25261-4, 14/19720-6, 15/25381-2, 11/07777-5)

BAYER-SANTOS, ETHEL; MARINI, MARJORIE M.; DA SILVEIRA, JOSE F.. Non-coding RNAs in Host-Pathogen Interactions: Subversion of Mammalian Cell Functions by Protozoan Parasites. FRONTIERS IN MICROBIOLOGY, v. 8, . Web of Science Citations: 8. (15/25381-2, 11/51475-3)

SGRO, GERMAN G.; COSTA, TIAGO R. D.; CENENS, WILLIAM; SOUZA, DIORGE P.; CASSAGO, ALEXANDRE; DE OLIVEIRA, LUCIANA COUTINHO; SALINAS, ROBERTO K.; PORTUGAL, V, RODRIGO; FARAH, CHUCK S.; WAKSMAN, GABRIEL. Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. NATURE MICROBIOLOGY, v. 3, n. 12, p. 1429-1440, . Web of Science Citations: 8. (17/17303-7, 11/07777-5)

CESETI, LUCAS M.; DE SANTANA, ELIANE S.; RATAGAMI, CAMILA Y.; BARREIROS, YASMIN; LIMA, LIDIA DOS PASSOS; DUNGER, GERMAN; FARAH, CHUCK S.; ALVAREZ-MARTINEZ, CRISTINA E.. The Xanthomonas citri pv. citri Type VI Secretion System is Induced During Epiphytic Colonization of Citrus. Current Microbiology, v. 76, n. 10, p. 1105-1111, . Web of Science Citations: 0. (11/22571-4, 16/08400-6, 14/19720-6, 17/02318-9, 18/01852-4, 14/25261-4, 11/07777-5)

ANTUNES, VICTOR U.; LLONTOP, EDGAR E.; VASCONCELOS, FERNANDA N. DA COSTA; DE LOS SANTOS, YOSSEF LOPEZ; OLIVEIRA, RONALDO J.; LINCOPAN, NILTON; FARAH, CHUCK S.; DOUCET, NICOLAS; MITTERMAIER, ANTHONY; FAVARO, DENIZE C.. Importance of the beta 5-beta 6 Loop for the Structure, Catalytic Efficiency, and Stability of Carbapenem-Hydrolyzing Class D beta-Lactamase Subfamily OXA-143. BIOCHEMISTRY, v. 58, n. 34, p. 3604-3616, . Web of Science Citations: 0. (17/17303-7, 17/22822-3)

SGRO, GERMAN G.; OKA, GABRIEL U.; SOUZA, DIORGE P.; CENENS, WILLIAM; BAYER-SANTOS, ETHEL; MATSUYAMA, BRUNO Y.; BUENO, NATALIA F.; DOS SANTOS, THIAGO RODRIGO; ALVAREZ-MARTINEZ, CRISTINA E.; SALINAS, ROBERTO K.; et al. Bacteria-Killing Type IV Secretion Systems. FRONTIERS IN MICROBIOLOGY, v. 10, . Web of Science Citations: 1. (17/17303-7, 17/02178-2, 18/01852-4)

DUNGER, GERMAN; GUZZO, CRISTIANE R.; ANDRADE, MAXUEL O.; JONES, JEFFREY B.; FARAH, CHUCK S.. Xanthomonas citri subsp citri Type IV Pilus Is Required for Twitching Motility, Biofilm Development, and Adherence. MOLECULAR PLANT-MICROBE INTERACTIONS, v. 27, n. 10, p. 1132-1147, . Web of Science Citations: 24. (11/22571-4, 11/07777-5)

OLIVEIRA, LUCIANA COUTINHO; SOUZA, DIORGE PAULO; OKA, GABRIEL UMAJI; LIMA, FILIPE DA SILVA; OLIVEIRA, RONALDO JUNIO; FAVARO, DENIZE CRISTINA; WIENK, HANS; BOELENS, ROLF; FARAH, CHUCK SHAKER; SALINAS, ROBERTO KOPKE. VirB7 and VirB9 Interactions Are Required for the Assembly and Antibacterial Activity of a Type IV Secretion System. Structure, v. 24, n. 10, p. 1707-1718, . Web of Science Citations: 4. (13/17883-2, 11/07777-5)

ABIKO, LAYARA AKEMI; VITALE, PHELIPE M.; FAVARO, DENIZE C.; HAUK, PRICILA; LI, DA-WEI; YUAN, JIAQI; BRUSCHWEILER-LI, LEI; SALINAS, ROBERTO K.; BRUSCHWEILER, RAFAEL. Model for the allosteric regulation of the Na+/Ca2+ exchanger NCX. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v. 84, n. 5, p. 580-590, . Web of Science Citations: 3. (13/50355-0, 13/17883-2, 11/07777-5)

DUNGER, GERMAN; LLONTOP, EDGAR; GUZZO, CRISTIANE R.; FARAH, CHUCK S.. The Xanthomonas type IV pilus. Current Opinion in Microbiology, v. 30, p. 88-97, . Web of Science Citations: 12. (11/07777-5)

OLIVEIRA, MAYCON C.; TEIXEIRA, RAPHAEL D.; ANDRADE, MAXUEL O.; PINHEIRO, GLAUCIA M. S.; RAMOS, CARLOS H. I.; FARAH, CHUCK S.. Cooperative Substrate Binding by a Diguanylate Cyclase. Journal of Molecular Biology, v. 427, n. 2, p. 415-432, . Web of Science Citations: 10. (11/07777-5)

SOUZA, DIORGE P.; OKA, GABRIEL U.; ALVAREZ-MARTINEZ, CRISTINA E.; BISSON-FILHO, ALEXANDRE W.; DUNGER, GERMAN; HOBEIKA, LISE; CAVALCANTE, NAYARA S.; ALEGRIA, MARCOS C.; BARBOSA, LEANDRO R. S.; SALINAS, ROBERTO K.; et al. Bacterial killing via a type IV secretion system. NATURE COMMUNICATIONS, v. 6, . Web of Science Citations: 45. (05/59243-3, 09/54009-3, 11/07777-5)

GUZZO, CRISTIANE R.; DUNGER, GERMAN; SALINAS, ROBERTO KOPKE; FARAH, CHUCK S.. Structure of the PilZ-FimX(EAL)-c-di-GMP Complex Responsible for the Regulation of Bacterial Type IV Pilus Biogenesis. Journal of Molecular Biology, v. 425, n. 12, p. 2174-2197, . Web of Science Citations: 24. (09/14477-8, 11/22571-4, 11/07777-5)

SOUZA, DIORGE P.; ANDRADE, MAXUEL O.; ALVAREZ-MARTINEZ, CRISTINA E.; ARANTES, GUILHERME M.; FARAH, CHUCK S.; SALINAS, ROBERTO K.. A Component of the Xanthomonadaceae Type IV Secretion System Combines a VirB7 Motif with a N0 Domain Found in Outer Membrane Transport Proteins. PLOS PATHOGENS, v. 7, n. 5, p. e1002031, . Web of Science Citations: 32. (05/59243-3)

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