CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Chemistry, Master in Sciences and Doctor in Physical-Chemistry at the State University of Campinas, Brazil. Has been a posdoctoral fellow at the Unitè de Bioinformatique Structurale of the Institut Pasteur in Paris, and at the State University of Campinas. Currently is adjunct professor at the Institute of Chemistry of the State University of Campinas. Works with protein modeling, particularly molecular dynamics simulations, and the application of numerical optimization methods to problems in computational chemistry and biochemistry. (Source: Lattes Curriculum)
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We propose the creation of a world-class multidisciplinary center dedicated to the development and application of advanced computational modeling techniques for the purpose of meeting the challenges in frontier problems in computational engineering and sciences, and promote substantial advancements in technological innovation, education and dissemination of knowledge in the broader area o…
Molecular modeling methods are an integral part of strategies for the determination of protein structures, with or without the use of experimental data. The extent of the role of modeling methods depends on the structural resolution of the experimental data. If the experimental data provides very precise information on the structure, the modeling strategies are used only to finely adjust …
Nuclear Hormone Receptors (NRs) are major targets for pharmaceuticaldevelopment. Many experiments demonstrate that their C-terminal Helix(H12) is more flexible in the Ligand Binding Domains (LBDs) withoutligand, this increased mobility being correlated with transcriptionrepression and human diseases. Crystal structures have been obtained inwhich the H12 is extended, suggesting the possib…
This project aims to investigate the molecular architecture of viruses with focus on the distribution of solvents, lipids, ions, and other small molecules in the viral structures. Viral structures are known from macromolecular crystallography and Cryo-EM, but these experimental methods provide information mostly on the protein and nucleic acid distributions. Soft components such as lipid …
In this research project we will study the effect of solvation on protein-protein association, using as an example the formation of the non-structural protein 9 dimer (NSP9) of SARS-CoV-2. NSP9 has been considered important for virus replication while human cells are being infected. It has been observed that this dimerization in solution occurs through a preserved ±-helicoidal motif calle…
The subject of this postdoctoral research is the structural dynamics and stability of Glycoside Hydrolases (GHs) in aqueous solutions having polyol sugar molecules and ethanol as co-sonvents, which are present in high concentration in industrial processes involving such enzymes. The main purpose of the project is to produce new knowledge about the behavior of such catalysts in non-convent…
Vaccine adjuvants are additives that assist in the immune response to antigens. The choice of adjuvants is limited by their effects on antigen stability or their affinity for antibodies, in addition to their potential toxicity and solubility. Recently, a new class of compounds, biocompatible ionic liquids (bio-IL) have been studied as vaccine adjuvants because they have great protein solv…
The structure of proteins and their folding mechanisms depend on the molecular environment, and are sensitive to small variations in temperature, pressure and the presence of organic molecules, known as co-solvents. TMAO and urea are two co-solvents whose effects on the stability of protein structures are well known, but the underlying molecular mechanisms are still not completely underst…
Ionic Liquids (ILs) are compounds formed by ions. Many ionic liquids are liquid at temperatures around 25°C. They also show physicochemical properties (low vapor pressure, high thermal stability, high viscosity, dissolution of various compounds, etc.) that make of them potential substances for a wide range of applications (electrochemical devices, catalysis, solvent for chemical reactions…
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Deep eutectic solvents (DESs) are mixtures with melting points significantly lower than those of their constituent components. With their unique physicochemical properties, DESs are promising materials for many applications. The extensive hydrogen bonding network of DESs is believed to be the primary reason for their low melting points. Understanding the molecular intricacies of the inter…
Riboswitches are a type of RNA molecule that act as receptors for specific metabolites and control gene expression. When a metabolite binds to the aptamer domain of the riboswitch, it causes alterations in its secondary and tertiary structure. Riboswitches, like proteins, are also modulated by various external factors, including cosolvents. However, the effects of cosolvents on the stabil…
| 1 / 1 | Ongoing grants |
| 4 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 12 / 11 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 22 / 20 | All research grants and scholarships |
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