Norberto Cysne Coimbra

• Abstract

  In view of the emergence of pandemics that devastate public health in Brazil and in the world, generating devastating effects on the population and, above all, leaving sequelae in the mental health of individuals with own experience of contagion or had close people who were affected by these diseases it is imperative that we undertake actions aimed at promoting strategies that improve peo…

  Testing emotional vulnerability to threat in adults using a virtual reality paradigm of fear associated with autonomic variables, AP.R

• Abstract

  There is a great scientific interest in the search of the neuropsychopharmacological bases of fear- and panic-like behaviour. Several studies suggest the mesencephalic tectum (MT) as responsible for the control of defensive responses elaborated during threatening situations. The deep layers of the superior colliculus (dlSC) are considered relevant structures for the elaboration of innate …

  Study of the role played by endocannabinoid and endovaniloid signalling in the pallidum on the activity of the neostriatum-pallido-nigral disinhibitory and nigro-tectal inhibitory pathways during the organization of innate fear of animals confronted to snakes, AP.R

• Abstract

  The study of the neuropsychopharmacological bases of the fear- and panic-related behaviour has been the focus of several scientific researches. The mesencephalic tectum (MT) has been considered as responsible for the control of defensive responses evoked during threatening situations. The deep layers of the superior colliculus (dlSC) and the dorsal columns of the periaqueductal grey matte…

  Study of corpus striatum and ventral mesencephalon endocanabinoid influence on neostriato-nigro-tectal GABAergic pathways during panic reactions of rodents threatened by venomous snakes, AP.R

(Only some records are available in English at this moment)

• Abstract

  We are conducting research to explore the behavioral variances observed in various strains of mice when exposed to snakes within a novel snake-enriched polygonal arena panic attack test (unpublished data). Our research investigates the impact of chronic stress, involving prolonged exposure to stressful conditions such as immobilization and repeated social stress encounters, on specific li…

  Characterization of depressive behavior in mice exposed to chronic variable stress models, BP.IC

• Abstract

  There is a growing interest in the neural bases of behaviours associated with anxiogenic and depressive-like effects. Innovative studies focused on biochemical and pharmacological mechanisms of cannabinoids seem to be suitable for providing new therapeutic targets for mental disorders treatment. Brain-derived neurotrophic factor (BNDF) and rampamycin-target protein complex 1 (mTOR1) signa…

  Study of the role of endocannabinoid and endovanilloid signaling in the paleostriatum in mental disorders on depressive-like behavior and instinctive fear of a psychobiological risk assessment test, BP.DR

• Abstract

  Post-traumatic stress disorder (PTSD) is considered by the Diagnostic and Statistical Manual of Mental Disorders as a disorder related to trauma and stressors caused by the experience of a traumatic event where, after such an event, there is an involuntary recall of it, triggering intense fear responses. In humans, there is a relationship between PTSD and chronic pain, in which PTSD poten…

  Study of the effect of photobiomodulation in a model of comorbidity between post-traumatic stress and chronic neuropathic pain in an environment threatened by snakes, BP.IC

(Only some records are available in English at this moment)

• Abstract

  The rostromedial region of the frontal lobe cortex (mPFC; medial prefrontal cortex) has been implicated in the modulation of fear- and anxiety-related defensive responses, organised in diencephalic and mesencephalic structures. Recent studies have shown that the anterior cingulate cortex (ACC), a structure that also integrates the mPFC, has glutamatergic neurons that play a relevant role …

  Study of the participation of the ventromedial hypothalamus and periaqueductal gray matter on nociceptive processes mediated by the anterior cingulate cortex, BE.EP.PD

• Abstract

  Neuronal apoptosis has been implicated in the pathophysiology of the anxiety disorders such as panic disorder with agoraphobia and post-traumatic stress disorder. In animal models of anxiety disorder, the chronic stress induces suppression of neural cell proliferation in the hippocampus. Otherwise, stress-induced atrophy and loss of hippocampal neurons are overcome by hippocampal neurogen…

  Nano-materials as a potential tool to anxiety disorder treatment: A pre-clinical study of carbon-based nano materials modulating neurogenesis and synapses in the hippocampus, BE.EP.PD

• Abstract

  Anxiety disorders belong to the most common psychiatric disorders with enormous burden to the patient and the society. Many of them are precipitated by stress and associated with exaggerated fear responses, which often result from classical and operant conditioning processes. In this context, studies in animal models revealed the importance of the two stress hormone systems with adrenali…

  Role of glucocorticoid, endocannabinoid and noradrenaline interactions during aversive conditioning in mice, BE.EP.PD