Professor Norberto Cysne Coimbra, neuroanatomist, neuropsychopharmacologist, psychobiologist, is Physician (1988) by School of Medicine of the Federal University of Espírito Santo State (Brazil). Master in sciences (Magister Scientiae) (Neuropsychobiology field), Summa cum Laude (1991) by Ribeirão Preto School of Philosophy, Sciences and Literature of the University of São Paulo (USP), Doctor in Sciences (Scientiae Doctor) (Morphology-Cellular Biology field) by Ribeirão Preto school of Medicine of the University of são Paulo (FMRP-USP) (1995), he was Professor Doctor of the Department of Morphology (Neuroanatomy Lecturer) of the FMRP-USP from 1995-2000 (and Assistant Professor from 1991 to 1995). After that, he has moved to the Department of Pharmacology of the FMRP-USP, and became "Livre Docente" (Faculty Member) by Department of Surgery and Anatomy of the FMRP-USP in 2010 (Examinations and Thesis performed in Neuroanatomy field), exerting the function of Associate Professor (level III) at the Department of Pharmacology of the Ribeirão Preto School of Medicine of the University of São Paulo (2013-2022). Senior Academic Grade (Full Professor) at FMRP-USP Department of Pharmacology (2022-). He has done Post-Doctorate in the Pain Imaging Neuroscience (PaIN) group of Physiology, Anatomy and Genetics Department of the University of Oxford 09/01/2006 to 30/06/2006, and in the Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) of the Clinical Neurology Department of the University of Oxford (Oxford, England, United Kingdom) from 01/07/2006 to 08/01/2007. In his current researches performed in the University of São Paulo (USP), his has been studying the neuroanatomical and neuropsychopharmacological bases of panic-like reactions, innate fear-induced antinociception, and the involvement of the pain endogenous modulatory system in the organization of other kinds of hipo-algesia, such as the post-ictal antinociception and the sweet substance-induced antinociception. Interactions between the striatum-nigral GABAergic disinhibitory and GABAergic nigro-collicular inhibitory neural pathways and the role of intramesencephalic/tecto-nigral endogenous opioid peptide-mediated pathways in the modulation of panic attacks have been the focus of the most recent approaches in Neurosciences by his team. In addition, the involvement of endocannabinoid-,serotonin-, noradrenaline-, and acetylcholine-mediated neurotransmissions in the elaboration of innate- and conditioned-fear, as well as in antinociceptive mechanisms have been also investigated. One of the most interesting interdisciplinary and translational approaches of his team is the study of neural bases of panic and innate fear-induced antinociception evoked by prey confronted with wild venomous and constrictor Brazilian snakes using innovative psychobiological models. Professor Coimbra and his collaborators have also been studying the neuroprotector, antipanic and antinociceptive effect of different fractions of Brazilian social wasps (Agelaia vicina; Polibya occidentalis) and spiders (Parawixia bistriata; Acanthoscurria gomesiana) venoms or endolynph in the forebrain and brainstem. (Source: Lattes Curriculum)
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There is a great scientific interest in the search of the neuropsychopharmacological bases of fear- and panic-like behaviour. Several studies suggest the mesencephalic tectum (MT) as responsible for the control of defensive responses elaborated during threatening situations. The deep layers of the superior colliculus (dlSC) are considered relevant structures for the elaboration of innate …
In view of the emergence of pandemics that devastate public health in Brazil and in the world, generating devastating effects on the population and, above all, leaving sequelae in the mental health of individuals with own experience of contagion or had close people who were affected by these diseases it is imperative that we undertake actions aimed at promoting strategies that improve peo…
The study of the neuropsychopharmacological bases of the fear- and panic-related behaviour has been the focus of several scientific researches. The mesencephalic tectum (MT) has been considered as responsible for the control of defensive responses evoked during threatening situations. The deep layers of the superior colliculus (dlSC) and the dorsal columns of the periaqueductal grey matte…
The electrical and chemical stimulation of the dorsal periaqueductal grey matter (dPAG) elicits panic-like explosive escape behaviour. Although neurons of the ventromedial hypothalamus (VMH) seem to organise oriented escape behaviour, when stimulated with excitatory amino acids at higher doses, non-oriented/explosive escape reactions can also be displayed. The aim of this work was to exam…
The medial prefrontal cortex can influence unconditioned fear-induced defensive mechanisms organised by diencephalic neurons that are under tonic GABAergic inhibition. The posterior hypothalamus (PH) is involved with anxiety- and panic attack-like responses. To understand this cortical mediation, our study characterised anterior cingulate cortex (ACC)-PH pathways and investigated the effe…
(Only some records are available in English at this moment)
There is a growing interest in the neural bases of behaviours associated with anxiogenic and depressive-like effects. Innovative studies focused on biochemical and pharmacological mechanisms of cannabinoids seem to be suitable for providing new therapeutic targets for mental disorders treatment. Brain-derived neurotrophic factor (BNDF) and rampamycin-target protein complex 1 (mTOR1) signa…
Post-traumatic stress disorder (PTSD) is considered by the Diagnostic and Statistical Manual of Mental Disorders as a disorder related to trauma and stressors caused by the experience of a traumatic event where, after such an event, there is an involuntary recall of it, triggering intense fear responses. In humans, there is a relationship between PTSD and chronic pain, in which PTSD poten…
Patients with Epilepsies frequently develop neuropsychiatric comorbidities associated with epileptic seizures. Amongst the most common we can highlight the anxiety and alterations in the nociception, like painful hypersensitivity. The present study aims to characterize alterations inanxiety-like and nociceptive behaviors in a strain of rats genetically susceptible to Epilepsy (WistarAudio…
Epilepsy is a chronic disorder of the brain characterized by abnormal and highly synchronous activity of neurons. This disorder is the fourth most common neurological condition in the world, and it is estimated 70 million people are affected by epileptic syndromes. Pharmacological treatment with antiepileptic drugs has been essential in most cases. However, a proportion of patients contin…
(Only some records are available in English at this moment)
Epilepsy is a brain disorder characterized by persistent predisposition to generate epileptic seizures and by neurological, cognitive, and psychosocial consequences. It is the fourth most common neurological condition in the world. An estimated 70 million people are suffering from some type of epileptic syndrome. Pharmacological treatment with antiepileptic drugs has been essential in mos…
The rostromedial region of the frontal lobe cortex (mPFC; medial prefrontal cortex) has been implicated in the modulation of fear- and anxiety-related defensive responses, organised in diencephalic and mesencephalic structures. Recent studies have shown that the anterior cingulate cortex (ACC), a structure that also integrates the mPFC, has glutamatergic neurons that play a relevant role …
Neuronal apoptosis has been implicated in the pathophysiology of the anxiety disorders such as panic disorder with agoraphobia and post-traumatic stress disorder. In animal models of anxiety disorder, the chronic stress induces suppression of neural cell proliferation in the hippocampus. Otherwise, stress-induced atrophy and loss of hippocampal neurons are overcome by hippocampal neurogen…
Anxiety disorders belong to the most common psychiatric disorders with enormous burden to the patient and the society. Many of them are precipitated by stress and associated with exaggerated fear responses, which often result from classical and operant conditioning processes. In this context, studies in animal models revealed the importance of the two stress hormone systems with adrenali…
| 2 / 2 | Ongoing research grants |
| 21 / 13 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 56 / 32 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 85 / 53 | All research grants and scholarships |
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