Graduation at Farmácia Bioquímica from Universidade de São Paulo (1978), master's and PhD at Genetics from Universidade de São Paulo (1991 and(1995). Has experience in Microbiology, focusing on Applied Microbiology, acting on the following subjects: genetics of resistance in Gram-negative bacteria and epidemiology os hospital infections. (Source: Lattes Curriculum)
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In recent years, with the emergence of multidrug-resistant and extremely drug-resistant organisms, there has been an increase in the use of polymyxins, which in some situations are the last therapeutic option. Resistance to polymyxins has been described and the most common mechanism found in isolates resistant to polymyxins are mutations in chromosomal genes (for example, pmrA, pmrB, mgrB…
Bacteria have been exposed to biocides and heavy metals for decades, either by the consequences of industrialization, such as the disposal of pollutants in water or soil, or even by effluent from hospitals. The current scenario in which multiresistant bacteria are widely disseminated worldwide in health care settings, such as hospitals, is alarming and of extreme concern to public health.…
There is growing concern about bacteria that cause hospital-acquired infections or in the community, especially the ones multiresistant to antibiotics (popularly named superbacteria) or those affecting patients with chronic infectious diseases. Therefore, this proposed Thematic Project covers highly specialized and innovative studies on genetics of antibiotic resistance in bacteria, inves…
Beta-lactamases -producing enterobacterias are globally spread mainly ESBL (CTX-M) and carbapenem resistant-enterobacterial isolates. The objective of this work was study the genetic and molecular epidemiology of ESBL and carbapenem resistant-Klebsiella isolates from patients of Northeast region of Sao Paulo State and the plasmids involved. Identification and antimicrobial susceptibility…
(Only some records are available in English at this moment)
Bacteria have been exposed to biocides and heavy metals for decades, either by the consequences of industrialization, such as the disposal of pollutants in water or soil, or even by effluent from hospitals. The current scenario in which multiresistant bacteria are widely disseminated worldwide in health care settings, such as hospitals, is alarming and of extreme concern to public health.…
Although there are few reports regarding Enterobacteriaceae and Non-Fermenting Gram-Negative (BGN-NF) bacilli causing meningitis, these bacteria can both cause community and/or hospitalar meningitis. The treatment of the patients is compromised since it is increasingly common strains which have important resistance mechanisms, for example, production of Extended Spectrum Beta-Lactamase En…
Nowadays, the main mechanism of resistance to antibiotics in gram-negative bacteria is the production of enzymes that degrade antibiotics, highlighting the beta-lactamase. Most beta-lactamase genes encoding are inserted in mobile genetic elements (MGE- Mobile Genetic Elements -Integrons, transposons, and insertion sequences) carried or not by plasmids. Sequencing of complete genome and ba…
(Only some records are available in English at this moment)
Enterobacteriaceae bacterial family has become increasingly important in human and animal infections. According to the Ministry of Agriculture, Livestock and Supply, Brazil is the main exporter of broiler chicken in the world, making chicken farming one of the main economic activities in Brazil. The research of pathogenic and antibiotic-resistant bacteria isolated from chicken meat has an…
Aminoglycosides have been used for the treatment of infections due to MDR (multidrug-resistant) Gram-negative pathogens. The high-level aminoglycoside resistance mediated by the production of 16S-RMTases has been described in Enterobacteriaceae and non-fermenting Gram-negative bacilli more frequently in recent years, reinforcing the important role that these enzymes play on the antimicrob…
The taxonomy of Achromobacter and Burkholderia deriving from cystic fibrosis (CF) patients needs special attention for a precise elucidation. Errors in the identification of those genera and other no fermenting species seriously compromise the infection control measures in patients with CF. Infections by Achromobacter and/or Burkholderia can result in accelerated decline in lung inflammat…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 20 / 8 | Completed research grants |
| 24 / 13 | Completed scholarships in Brazil |
| 7 / 6 | Completed scholarships abroad |
| 52 / 28 | All research grants and scholarships |
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CV Lattes
ORCID