José Maria Álvarez Mosig

• Abstract

  In Chagas disease, a human ailment due to infection by the protozoan Trypanosoma cruzi, one third of the patients develop chronic cardiomyopathy. This pathological condition is associated with persistence of the parasite in the cardiac tissue, which is considered to be a reflex of an insufficient or inadequate local immune response. However, using a murine model of acute T. cruzi infectio…

  The heart infection by Trypanosoma cruzi: analysis of the role of cardiomyocytes in the detection of the parasite and/or tissue damage, AP.R

• Abstract

  Dead cells as a result of tissue damage are quickly engulfed, but before disappearing, warn the surrounding cells so that repair programs are activated. The recognition of cell damage by the innate immune system contributes to the development of inflammatory immune responses and tissue repair, but may also exacerbate tissue injuries. In some cases, uncontrolled cell death can trigger a ca…

  Intervention in signaling pathways associated with the recognition of cellular damage to reduce the pathology of severe forms of malaria and tuberculosis, AP.TEM

• Abstract

  Considering that low virulence Trypanosoma cruzi strains may account for a significant fraction of the parasites responsible for the human Chagas infection, the present project aims to continue our studies in the murine model of infection by Sylvio X10/4 parasites, a T. cruzi clone that induces very low levels of parasitaemia in immunocompetent mice and in C3H/HePAS mice promotes the deve…

  Study of the murine infection by Trypanosoma Cruzi clone Sylvio X10/4, a low virulence parasite, AP.R

(Only some records are available in English at this moment)

• Abstract

  Chronic chagasic cardiomyopathy (CCC) is the most important morbid element of Chagas disease and its elucidation has become fundamental. Immunology studies of CCC demonstrate that the local immune response plays a dual role in the disease, acting to control the parasite but simultaneously promoting tissue injury. However, there is little information about the role of heart structural cell…

  MODULATION OF CARDIOMYOCYTE SIGNALING BY PRIMING WITH CITOKINES, BP.MS

• Abstract

  Chagas disease, a human disease induced by the flagellate protozoan Trypanosoma cruzi, has no spontaneous cure, progressing to chronicity. In the chronic phase, a significant fraction of patients develop diseases of the heart and/or digestive tract, which appear to be the result of local damage induced by the parasite and immune system. It is unknown the responsible cause for the ineffici…

  Analysis of the modulatory role of PD-1/PD-L1 interaction in the chronic phase of the murine infection with Trypanosoma cruzi, BP.DD

• Abstract

  Chagas disease, a human disease induced by the flagellate protozoan Trypanosoma cruzi, has no spontaneous cure, progressing to chronicity. In the chronic phase, a significant fraction of patients develop diseases of the heart and/or digestive tract, which appear to be the result of local damage induced by the parasite and immune system. It is unknown the responsible cause for the ineffici…

  ANALYSIS OF THE EVENTUAL MODULATORY ROLE OF PD-1/PD-L1 INTERACTION IN THE CHRONIC PHASE OF THE MURINE INFECTION WITH Trypanosoma cruzi, BP.MS

(Only some records are available in English at this moment)

• Abstract

  Tissue resident memory (TRM) cells are newly discovered type of T cell memory cell, which is characterized by not recirculating through lymphoid organs and blood, but by being restricted to non lymphoid organs where several infectious agents are concentrated. Considering this, these cells are responsible for beginning the specific response upon reinfection, starting the signals for inflam…

  Role of PD-1 pathway in TRM development and function, BE.EP.DD