CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Bacharelado Em Química from Universidade Estadual Paulista Júlio de Mesquita Filho (1996), master's at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1999) and doctorate at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (2003). Has experience in Chemistry, acting on the following subjects: complexos pirazólicos de paládio, pseudo-haletos, paládio(ii), polímeros de coordenação and auto-organização molecular. (Source: Lattes Curriculum)
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This project deals with the synthesis, characterization and evaluation of the antitumor potential of compounds [PdCl(C2,N-ox)(PR3)], [Pd2Cl2(C2,N-ox)2(µ-PP)] and [PdCl(CINTSC)(PR3)] (PR3 = tertiary monodentate phosphanes, PP = diphosphanes; ox = orthometallated oximes functionalized or not, CINTSC = thiosemicabazones derived from cinmaldehyde). The compounds will be characterized by eleme…
This project deals with the synthesis, characterization and evaluation of cathepsin B inhibitory activity, involving chelated compounds of the type [{Pd(N C)X}(PR3)] {N C = C2,N-bzox, C2,N-mbz, C2,N-bzan (bzox=benzaldehydeoxime, mbz = N-benzylidenemethylamine, bzan = N-Benzylideneaniline); X = Cl or dmf; (PR3) = triphenylphosphine (PPh3), tricyclohexylphosphine (PCy3), tris(p-tolyl)phosp…
The main objective of this project is the design of new thiosemicarbazones and their Cu(II) and Pd(II) square planar complexes which act as inhibitors of DNA topoisomerase II ±. The interaction between the compounds and topoisomerase will be evaluated by agarose gel electrophoresis assay. The biological activity of the most promising compounds will be evaluated by MTT assays against the m…
This work deals with the synthesis, characterization, and cytotoxicity evaluation of chelated compounds of the type [PdX2(N;S)] and [Pd(N;S)2]Cl2 {N;S = N-substituted-1-thiocarbamoylpyrazoles; X=Cl, Br, I, SCN}. The compounds will be characterized by elemental analysis, IR and NMR spectroscopies, ESI/MS mass spectrometry, thermogravimetry (TG) and single crystal X-ray diffraction methods.…
This work deals with the synthesis, characterization and human telomeric G-quadruplex DNA binding studies on new chelates of general formulae [M(bisq)(N-X)]+n (M = Pd(II), Pt(II); bisq = 3,32-biisoquinoline; N-X (X = C) = C2,N-benzylidenemethylamine, C2,N-benzaldehydeoxime type-ligands; N-X (X = S) = thiosemicarbazide type ligands; n = 1,2). These complexes exhibit pre-conceived structura…
| 3 / 3 | Completed research grants |
| 7 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 11 / 7 | All research grants and scholarships |
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