CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduation: Biology (University of São Paulo, 1989), MSc. Physiology (University of São Paulo, 1992), PhD: Physiology (University of São Paulo, 1995), Research Associate at University of Oxford, UK (1995/1996), University of Potsdam, Germany (2003, 2005), University of Barcelona, Spain (2008). Livre-Docência ((University of São Paulo, 2004). Associate Professor III, Head of the Cancer Metabolism Group, University of São Paulo, Medical School, USP, Head of LIM26 HC-USP. Board Director (2022-2024), Cancer cachexia Society. Member, Muhyddin Ibn Arabi Society, Member, Society on Cachexia, Sarcopenia Muscle Wasting, Member, ESPEN. Fields of interest: cancer cachexia, lipid metabolism, adipose tissue, physical exercise, nutrition. Editor Frontiers in Clinical Nutrition, Frontiers in Pharmacology: Gastrointestinal and Hepatic Pharmacology, Review Editor Frontiers in Physiology: Frontiers in Oncology- Molecular and Cellular Oncology. Review Editor, Associate Editor Journal of Cachexia Sarcopenia and Muscle. Associate Editor (Cancer) Nutrition; Director, Cancer Cachexia Society, Head of the Post-graduation program in Anesthesiology, Surgical Sciences and Perioperative Medicine. Ombudsperson for the University of Sao Paulo (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Reversing Wasting Syndrome |
| Delgadez reversible |
| Delgadez reversible |
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| News published in Agência FAPESP Newsletter about the researcher |
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Hypothesis: White Adipose tissue (WAT) contributes, as a major endocrine gland, to the cytokine storm and systemic effects of the infection.Justification: i) WAT is a major component of inflammatory response in cachexia, a systemic disease in which hypoxia, inflammation and fibrosis occur in major organs. Therefore, it is possible to expect similarities, given the recent description of or…
Cachexia is a devastating wasting syndrome associated with poor prognosis and survival of cancer patients. Its aetiology has not been fully unveiled and the syndrome is frequently under diagnosed, despite afflicting around 40% of all cancer patients, and 80% of hospitalized patients. Chronic systemic inflammation is a main feature of cachexia, to which the white adipose tissue (WAT) plays…
(Only some records are available in English at this moment)
Cancer cachexia (CC) is a multifactorial syndrome characterized by weight loss with wasting of muscle tissue, with or without loss of fat mass. The common clinical manifestations are anorexia, chronic systemic inflammation, and catabolism, which can affect the quality of life/survival span and the tolerance of anti-cancer treatments, leading to cancer-related deaths. Currently, there are …
Lubricin (also known as proteoglycan 4, or PRG4 and expressed by the PRG4 gene) is a proteoglycan found in the cartilage, synovial membrane and synovial fluid of the knee joint capsule and it is responsible for protection against wear and growth inhibition associated with adhesion in this articulation.Its presence is associated with the inhibition of the pathophysiological process osteoar…
Cachexia is a metabolic disorder characterized by rapid weight loss (muscle and adipose tissue), which affects up to 80% of patients with advanced Cancer, and is related to functional decline and survival. Pro-inflammatory cytokines, such as TNF-± and IL-6, directly contribute to the progression of this condition. The regulation of inflammation, through activation of Toll-like receptors 4…
The intense study of a new virus of the betacoronavirus family, SARS-CoV-2, started from the COVID-19 pandemic, due to its high transmission and deaths caused by the infection, this virus was associated with MERS-CoV and SARS-CoV, a virus already seen in the literature. SARS-CoV-2 is a simple RNA virus, and encodes non-structural and structural proteins. Among the structural proteins of t…
Cancer affects millions of people and presents high mortality rates. One of the treatments proposed is based on immunotherapy, which stimulates the patient's immune system to fight the disease. However, the hostility of the tumor microenvironment, characterized by hypoxic regions and immunosuppression, proves to be a challenge for the success of the intervention. The low levels of oxygen,…
The recent emergence of the novel coronavirus (SARS-CoV-2/COVID-19) has quickly become a worldwide threat to health, causes severe respiratory syndrome in human. SARS-Cov-2 likely facilitates entry into cells via Angiotensin-converting enzyme 2 (ACE2) expressed by pneumocytes, pulmonary macrophages, heart, kidneys and intestine. The physiological role of ACE2 is in the maturation of angio…
(Only some records are available in English at this moment)
Cancer cachexia is a multifactorial and systemic syndrome whose aetiology remains elusive. Clinically, cancer cachexia has been defined as a "muscle-wasting syndrome that compromises therapeutic approaches, leads to a poor prognosis, reduced survival and is directly correlated with death in up to 40% of cancer patients". Available evidence suggests that systemic inflammation which charact…
Hypoxia induces dramatic proliferation of type I carotid body cells (Fielding, 2018; Hoodson, 2016, Macias, 2018). Studies made with CRE-Lox animals provided evidence that HIF-2 but not HIF-1-mediated signaling is necessary for this process (Hodson et al., 2016). Hodson, et al (2016) showed that inducible inactivation of HIF2± could decreases the ventilatory sensitivity after chronic hypo…
Cancer cachexia is a syndrome with severe and fast involuntary weight loss. It affects around 80% of patients with advanced cancer and is the direct cause of death of a large proportion of these. Recent studies have shown that inflammatory mediators are active players in the development of cachexia, considered nowadays a chronic inflammatory condition. The white adipose tissue is a contri…
(Only some records are available in English at this moment)
| 17 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 31 / 15 | Completed scholarships in Brazil |
| 6 / 4 | Completed scholarships abroad |
| 57 / 28 | All research grants and scholarships |
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