Graduation: Biology (University of São Paulo, 1989), MSc. Physiology (University of São Paulo, 1992), PhD: Physiology (University of São Paulo, 1995), Research Associate at University of Oxford, UK (1995/1996), University of Potsdam, Germany (2003, 2005), University of Barcelona, Spain (2008). Livre-Docência ((University of São Paulo, 2004). Associate Professor, Head of the Cancer Metabolism Group, University of São Paulo, Medical School, USP, Head of LIM26 HC-USP. Director, Cancer cachexia Society. Fields of interest: cancer cachexia, lipid metabolism, adipose tissue, physical exercise, nutrition. Editor Frontiers in clinical Nutrition, Frontiers in Pharmacology: Gastrointestinal and Hepatic Pharmacology, Review Editor Frontiers in Physiology: Striated Muscle Physiology, Guest Associate Editor and Frontiers Topic Editor: Myokines, Adipokines, Cytokines in Muscle Pathophysiology,Frontiers in Oncology- Molecular and Cellular Oncology. Review Editor, Associate Editor Journal of Cachexia Sarcopenia and Muscle.Associate Editor (Cancer) Nutrition; Director, Cancer Cachexia Society, Head of the Post-graduation program in Anesthesiology, Surgical Sciences and Perioperative Medicine. Ombudsperson for the University of Sao Paulo (Source: Lattes Curriculum)
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| Reversing Wasting Syndrome |
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| Delgadez reversible |
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Hypothesis: White Adipose tissue (WAT) contributes, as a major endocrine gland, to the cytokine storm and systemic effects of the infection.Justification: i) WAT is a major component of inflammatory response in cachexia, a systemic disease in which hypoxia, inflammation and fibrosis occur in major organs. Therefore, it is possible to expect similarities, given the recent description of or…
Cachexia is a devastating wasting syndrome associated with poor prognosis and survival of cancer patients. Its aetiology has not been fully unveiled and the syndrome is frequently under diagnosed, despite afflicting around 40% of all cancer patients, and 80% of hospitalized patients. Chronic systemic inflammation is a main feature of cachexia, to which the white adipose tissue (WAT) plays…
(Only some records are available in English at this moment)
Cachexia is a metabolic disorder characterized by rapid weight loss (muscle and adipose tissue), which affects up to 80% of patients with advanced Cancer, and is related to functional decline and survival. Pro-inflammatory cytokines, such as TNF-± and IL-6, directly contribute to the progression of this condition. The regulation of inflammation, through activation of Toll-like receptors 4…
Cancer affects millions of people and presents high mortality rates. One of the treatments proposed is based on immunotherapy, which stimulates the patient's immune system to fight the disease. However, the hostility of the tumor microenvironment, characterized by hypoxic regions and immunosuppression, proves to be a challenge for the success of the intervention. The low levels of oxygen,…
The recent emergence of the novel coronavirus (SARS-CoV-2/COVID-19) has quickly become a worldwide threat to health, causes severe respiratory syndrome in human. SARS-Cov-2 likely facilitates entry into cells via Angiotensin-converting enzyme 2 (ACE2) expressed by pneumocytes, pulmonary macrophages, heart, kidneys and intestine. The physiological role of ACE2 is in the maturation of angio…
Cachexia is a multifactorial syndrome associated with underlying disease, such as cancer. It is characterized by involuntary loss of skeletal muscle mass, anorexia and marked systemic inflammation. The observed changes are caused by several factors such as cytokines, secreted by the host itself due to metabolic alterations. Studies reported that systemic inflammation leads to central nerv…
(Only some records are available in English at this moment)
Cancer cachexia is a multifactorial and systemic syndrome whose aetiology remains elusive. Clinically, cancer cachexia has been defined as a "muscle-wasting syndrome that compromises therapeutic approaches, leads to a poor prognosis, reduced survival and is directly correlated with death in up to 40% of cancer patients". Available evidence suggests that systemic inflammation which charact…
Hypoxia induces dramatic proliferation of type I carotid body cells (Fielding, 2018; Hoodson, 2016, Macias, 2018). Studies made with CRE-Lox animals provided evidence that HIF-2 but not HIF-1-mediated signaling is necessary for this process (Hodson et al., 2016). Hodson, et al (2016) showed that inducible inactivation of HIF2± could decreases the ventilatory sensitivity after chronic hypo…
Cancer cachexia is a syndrome with severe and fast involuntary weight loss. It affects around 80% of patients with advanced cancer and is the direct cause of death of a large proportion of these. Recent studies have shown that inflammatory mediators are active players in the development of cachexia, considered nowadays a chronic inflammatory condition. The white adipose tissue is a contri…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 16 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 30 / 14 | Completed scholarships in Brazil |
| 6 / 4 | Completed scholarships abroad |
| 54 / 25 | All research grants and scholarships |
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CV Lattes
ORCID