Bruno Cogliati

• Abstract

  Connexin and pannexin proteins are the building stones of hemichannels and channels, respectively, which are transmembrane pores that mediate paracrine cellular communication, in particular in pathological conditions. Belgian-Brazilian joint research over the past years showed altered expression of connexin43 and pannexin1 in acute and chronic liver disease as well as alleviation of the c…

  Are connexins, pannexins and their (hemi)channels novel biomarkers and pharmacological targets in the prognosis and therapy of liver cancer?, AP.R

• Abstract

  Although being in its infancy and surrounded by controversy, it is now believed that connexin (Cx) hemichannels and pannexin (Panx) channels act as pathological pores that connect the cytoplasm of cells with the extracellular environment and which facilit (AU)

  Connexin and pannexin channels as drug targets and biomarkers in acute and chronic liver disease, AP.SPEC

• Abstract

  The nonalcoholic fatty liver disease (NAFLD) is closely related to obesity and can evolve from steatosis to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. Steatosis is considered an important risk factor in the progression of fibrosis, mostly by the secretion of cytokines and growth factors by the fatty hepatocytes. The paracrine release of these substances promotes th…

  3D co-culture of fatty hepatocytes and stellate cells: evaluation of fibrogenesis induced by steatosis in a new in vitro model of nonalcoholic fatty liver disease, AP.R

(Only some records are available in English at this moment)

• Abstract

  Hepatocellular Carcinoma (HCC) is the most common malignant neoplasm in the liver, of which ~ 90% of cases arise in patients with chronic liver diseases. The diagnosis of HCC is usually late, a stage in which it is highly refractory to conventional treatments, resulting in high rates of morbidity and mortality. Therefore, an immediate search for new biomarkers and therapeutic approaches f…

  Investigation of the functional role and therapeutic potential of Pannexin1 channels in Hepatocellular Carcinoma: a translational approach, BP.DD

• Abstract

  Breast cancer is a neoplasia with great importance in women and also has a high prevalence in small animals. These tumors are classified histologically and sub classified according to immunohistochemical and molecular markers, which are directly related to predictive and prognostic factors in humans. In cats, the majority of breast tumors do not express receptors for estrogen (ER) and pro…

  Mutational evaluation of BRCA1 and BRCA2 genes in breast tumors in cats and correlation with clinical, histopathological and immunohistochemical aspects, BP.MS

• Abstract

  The autosomal dominant polycystic kidney disease (ADPKD) is one of the congenital hereditary diseases that most affects cats, mainly Persian breed, which is characterized by development of cysts in renal parenchyma and, eventually, in other organs, leading to a commitment of their functions and a guarded to poor prognostic. The ADPKD in felines has, as main genetic change, transversion of…

  Comparative study of DNA extraction in different biological material sources to performance the polymerase chain reaction (PCR) in the diagnosis of Polycystic Kidney Disease in Persian cats, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Non-alcoholic esteatohepatitis (NASH) is a rising public health threat that is increasingly complicated by hepatocellular carcinoma. NASH is characterized by steatosis, hepatocyte injury, inflammation, and fibrosis; and is associated with features of the metabolic syndrome, including type 2 diabetes, obesity, hypertension, and hyperlipidemia. Recently, we have developed a highly efficient…

  Characterization of the dynamics of hepatic stellate cell (HSC) turnover and their contribution to non-alcoholic steatohepatitis (NASH), BE.PQ