CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Hospital das Clínicas da Faculdade de Medicina de Botucatu (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate degree at Biology at Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto/USP (1982), MSc(1986) and PhD (1990) in Genetics at Faculty of Medicine, USP- Ribeirao Preto, SP. She has expertise in Human Genetics and Oncology developing research projects oriented towards precision medicine. (Source: Lattes Curriculum)
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Thyroid nodules are common in adult population, being detected in up to 70% of cases by ultrasound tests. However, current diagnostic methods have limitations in distinguishing malignant from benign follicular lesions, resulting in a significant number of potentially preventable surgeries. Thus, molecular diagnostic and prognostic tools useful in the clinical practice for thyroid lesions …
Penile carcinoma (PeCa) represents an important public health problem in poor and developing countries. Brazil presents one of the highest incidence rates worldwide of this disease. The etiology and many aspects of the pathophysiology of PeCa are still poorly elucidated. To date there are few data on the molecular and epigenetic mechanisms reported in the literature. Using large-scale tec…
Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an important public health issue for poor and developing countries. Contrary to most tumors, limited data are available for markers that are capable of assisting in diagnosis, prognosis, and treatment of PeCa. We aimed to identify molecular markers for PeCa by evaluating their epigenomic and transcriptome profile…
(Only some records are available in English at this moment)
Background: Ovarian cancer (OC) is the most lethal among gynecological cancers. Among the epithelial OC, which is the most prevalent, the high-grade serous ovarian carcinoma subtype is the most incident and aggressive. Initial treatment involves cytoreductive surgery and platinum-based chemotherapy, in which patients are initially responsive. The asymptomatic nature of OC leads to advance…
Hereditary cancer syndromes are estimated to account for 10% of all tumors, while 15% of cases are associated with familial aggregation of cancer. The etiology of solid tumors, including breast carcinomas (BC) and thyroid carcinomas (TC), is multifactorial, dependent on environmental and genetic factors playing a variable role in the disease etiology. However, a significant incidence of t…
Colon and rectal tumors are different, not only regarding their location, but also in the type and frequency of genomic and epigenomic alterations. Furthermore, it has been reported different genes and pathways involved in tumors from distinct anatomic location. Colon or rectal tumor resection is recommended in early stages, and in the majority of cases is followed by chemotherapy. Howeve…
Squamous cell carcinoma (SCC) is the most common disease of the head and neck (HN), being the eighth cause of cancer death in the world. The most important risk factors described for SCCHN are the alcohol consumption and smoking habit, in addition to human papillomavirus infection. A group of SCCHN patients aged under 45 years is characterized by the most severe form of the disease and ar…
(Only some records are available in English at this moment)
Stage II-III rectal carcinoma (ReCa) patients undergo neoadjuvant chemoradiotherapy (nCRT) followed by surgery. Those who achieve pathological complete response (pCR) have better prognosis and could be spared of a highly morbid procedure if pCR was accurately identified precociously. However, the current molecular studies have shown inconclusive results. Our study aims to evaluate the gen…
Penile carcinoma (PeCa) is a frequent disease in poor and developing countries showing high morbidity. Despite of the progress in the molecular research of PeCa, including very recently published high-throughput studies conducted by our group, the lack of well characterized in vitro models precludes new advances in the knowledge of cellular processes as well as in preclinical tests for an…
| 29 / 13 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 52 / 12 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 85 / 28 | All research grants and scholarships |
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