CV Lattes
ORCID
Abstract
This system is used to concentrate and/or dry thermosensitive samples by evaporation or by sublimation, including biomolecules such as proteins, lipids, peptides and nucleic acids. (AU)
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Ohara Augusto is Full Professor at the Biochemistry Department, Chemistry Institute, University of São Paulo. She received a Bachelor's Degree in Chemistry and a PhD in Biochemistry from the same institution. She did postdoctoral studies at the University of California Berkeley and University of California, San Francisco. Her research interests have always been focused on the understanding of the multiple roles of radicals and oxidants in physiology and pathophysiology; her specialties include the biochemistry of oxidants and free radicals, kinetics and mechanisms of redox enzymes, oxidant and antioxidant mechanisms, infectious and inflammatory processes and applications of electron paramagnetic resonance spectroscopy (EPR) in biomedicine. She received the title of Fellow of the SFRBM (Society for Redox Biology and Medicine) (2000), the Medal for Biology of the International EPR Society (2002), the title of Adhonorum Professor at the Faculdad de Medicina, Universidad de la Republica, Uruguay (2006), the title of ?Comendador? of the Brazilian Order of Scientific Merit (2006), the "Rheinboldt-Hauptmann" Prize (2018), the "Brazilian Women in Chemistry (Academic Leader) Prize from American Chemical Society/Sociedade Brasileira de Química (2022) and the "2022 Lifetime Achievement Award" from the Society for Redox Biology & Medicine. She is member of the Brazilian Academy of Sciences (since 2002), the Academy of Sciences of the State of São Paulo (since 2011) and the TWAS (World Academy of Sciences) (since 2011). She was one of the Associate Editors of Free Radical Biology & Medicine from 2013-2018 and is the author of the educational book ?Radicais livres: bons maus e naturais? (Free radicals: Good, bad and natural). (Source: Lattes Curriculum)
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Research grants
- Multi-User equipment approved in grant 2013/07937-8: Freeze Dryer, AP.EMU
- Multi-user equipment approved in grant 2013/07937-8: FPLC, AP.EMU
Abstract
The equipment allows the separation and purification of biomolecules such as proteins, peptides and nucleic acids through columns and chromatographic resins. (AU)
- Multi-User Equipment approved in grant 2013/07937-8: EPR Spectrometer, AP.EMU
Abstract
The equipment allows the detection and quantification of paramagnetic species (radicals and metal centers). (AU)
(Only some records are available in English at this moment)
- São Paulo Advanced School on Redox Processes in Biomedicine | São Pedro – SP, AO.R.ESPCA
Abstract
The I São Paulo Advanced School on Redox Processes in Biomedicine is a forum of discussions on the study of cellular redox processes, concerning chemistry, biochemistry, molecular and cellular biology and medicine. The design prioritizes an integrative and translational approach, with emphasis on mechanisms of redox processes associated with human disease. This international scientific me…
- Redoxome, AP.TEM
Abstract
The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
- Mechanisms and pathophysiological consequences of redox process. Emphasis in processes mediated by bicarbonate buffer, superoxide dismutase 1, thiol proteins and nitroxides, AP.TEM
Abstract
Currently, free radicals and oxidants are considered to mediate responses that range from signaling circuits involved in physiology and pathology to cellular and tissue injury. It is widely conceded that the elucidation of these many inter-related processes requires a better understanding of cellular oxidative mechanisms, including the identification of involved oxidants, the pathways reg…
(Only some records are available in English at this moment)
Scholarships in Brazil
- Characterization of ditryptophan and tryptophan-tyrosine cross-links: A step to a better understanding of protein aggregation, BP.PD
Abstract
Protein oxidation is an unavoidable consequence of aerobic metabolism. The oxidation of most proteins residues is non-repairable and may affect protein structure and function. In particular, protein cross-links are toxic to cells because they may accumulate and induce protein aggregation, which is a hallmark of aging-related diseases. However, most of these irreversible protein cross link…
- Carbon dioxide redox metabolites in oxidative eustress and oxidative distress, BP.PD
Abstract
Carbon dioxide (CO2) levels are increasing in the atmosphere and inside modern refrigerated buildings. High CO2 tensions (hypercapnia) are toxic to mammals by both pH-dependent and pH-independent mechanisms that remain partially understood. Relevantly, CO2 reacts with biologically ubiquitous oxygen metabolites such as peroxynitrite and hydrogen peroxide to produce carbonate radical and pe…
- Protein cross-links produced by radical mechanisms: characterization and roles in protein aggregation, BP.PD
Abstract
Our lab constructed a MS database of the soluble fraction of human crystalline from patients submitted to cataract surgery and was able to publish part of these results recently. This publication constituted the first characterization of Trp-Trp and Trp-Tyr cross-links in biological samples. To progress in the understanding of the role of these cross-links in the pathogenic mechanism of h…
- Influence of the bicarbonte/carbon dixide buffer on biological oxidations: in vitro and cell culture studies, BP.DD
Abstract
Although crucial for physiological pH control, as the pair bicarbonate/carbon dioxide (bicarbonate buffer), carbon dioxide is toxic to mammals in high levels (hypercapnia) as extensively reported. Usually considered a stable molecule, carbon dioxide reacts with biologically ubiquitous oxygen metabolites such as peroxynitrite and hydrogen peroxide, to produce the carbonate radical and pero…
(Only some records are available in English at this moment)
Scholarships abroad
- Biomimetic dinitrosyl iron complexes: formation and S-nitrosation capability, BE.EP.PD
Abstract
High molecular weight dinitrosyl iron complexes (DNICs) have been consistently detected in cell and tissues in situations of nitric oxide overproduction since 1965. Despite this fact, the structures of biological DNICs remain unknown whereas the reactivity of synthetic DNICs received limited attention in the literature. Biological DNICs have been proposed to act as nitric oxide reservoirs…
Total / Available in English
| 7 / 7 | Ongoing grants |
| 20 / 15 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 37 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 66 / 32 | All research grants and scholarships |
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