Ana Paula Ramos in research grants and scholarships supported by FAPESP.
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Biominerals are commonly found in nature in the form of hybrid organic-inorganic compounds, in which the organic portion is mainly composed by proteins and polyssacharides. On it is turn, the in the inorganic portion carbonates and phosphates can be found, mainly as hydroxyapatite (HAp) and silica. The process by which these exquisite minerals are formed is named biomineralization and can…
The synthesis of highly-ordered nanostructured materials that offer specific responses when submitted to an external stimulus is one of the application of nanotechnology. The ability to investigate substances at the molecular level started the search for materials with improved properties to medical applications. The use of these molecularly-controlled materials gave rise to a new researc…
Biomineralization is the processes from which minerals are formed in living organisms. This process generates complexes systems like bones, tooth, and pearls (nacre), in which organic matrices formed by macromolecules as lipids and proteins are bonded chemicaly and/or physically being responsible for the modifications in the local supersaturation of the ions which origins the nucleation a…
Design of three-dimensional hybrid and injectable templates (scaffolds) has emerged as a promisor approach to produce biomaterials for targeted applications. In this sense, the properties of the materials should be tuned to improve its therapeutic effect in the host tissue and to become a material able to easily adapt and shape to any type of bone defect. On that account, the use of bioac…
This project aims to obtain hydroxyapatite (HAp) nanoparticles, in which Ca2 + ions will be replaced by Sr2 + in different molar ratios. Sr2 + can replace Ca2 + in the structure of HAp due to similarity of charge and size between these two ions. In addition, the presence of strontium is associated in vivo to the reabsorption control and increased bone formation. This ion is usually admini…
Bone biomineralization is an exquisite process mediated and controlled by cells that culminate in the building of a highly hierarchical hybrid matrix. The building block of this matrix is the mineralized collagen fibrils, where hydroxyapatite (HAp) crystals are infiltrated in the fibril. The origin of these HAp crystals is regarded to the action of Matrix Vesicles (MV). These lipid vesicl…
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Understanding the bone formation process involves the difficult task to realize how both time and nature acted harmonically in a unique association between calcium phosphate and collagen that gave rise to one of the most remarkable biomaterials we have ever known. The bone consists of a porous hybrid organic/inorganic three-dimensional (3D) matrix, composed mainly by collagen, a variety o…
Biomineralization of hard tissues such as bone and dentin involves a complex spatio-temporal sequence of events regulated by bone-forming cells. One big question that still perdures on the understanding of this process is the origin of the mineral phase. It has been claimed since their discovery in the decade of 1960, that matrix vesicles (MVs) are the entities responsible to nucleate and…
The inorganic compounds present in living organisms are formed by a complex mechanism (biomineralization) which involves steps of nucleation and growth within a confined space. The need of design new bone replacement materials has driven several studies towards the process of bone formation. Bone is a hybrid material formed of plate-like non-stoichiometric hydroxyapatite (HAp) crystals an…
The continuing interest of strontium (Sr2+) for bone tissue engineering purposes is related to its remarkable effects in the treatment of osteoporosis. In this sense, several biomaterials have been developed in order to create systems that promote the controlled delivery of Sr2+ to stimulate positive effects on bone metabolism. However, the intrinsic effect of this cation on the bone stru…
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 15 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 23 / 19 | All research grants and scholarships |
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