- Research Grants
graduation at Ciências Biológicas from Universidade de São Paulo (2014). Has experience in Physiology, focusing on Physiology (Source: Lattes Curriculum)
|News published in Agência FAPESP Newsletter about the researcher|
|Melatonin levels can be used as an indicator of tumor malignity|
Gliomas, the most frequent primary brain tumor in adults, are classified into four (I-IV) histological grades. Gliomas grade IV, known as glioblastomas, are highly aggressive tumors associated with a median survival of only 15 months. In vitro studies have shown that high concentrations of melatonin, a hormone synthesized mainly by the pineal gland, significantly reduce the migration an...
Gliomas are recurrent primary brain tumors classified according its proliferation rate and invasiveness. A preliminary study of gene expression in material obtained from patients with glioma showed a significant negative correlation between the grade of invasiveness and the expression of the gene that encodes the enzyme responsible for converting N-acetylserotonin (NAS) in melatonin (ME...
Cellular plasticity and heterogeneity are fundamental features of human tumors and arise as a consequence of genetic and epigenetic mechanisms, as well as environmental signals. Such diversity is considered an important source of treatment failure, as subpopulations of drug-resistant cells may underlie tumor recurrence and metastasis. In the tumor ecosystem, malignant and stromal cells ...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|