Rodrigo Portes Ureshino

• Abstract

  The SARS-CoV-2 (severe acute respiratory syndrome coronavirus) pandemic has become a major global concern, mainly due to impacts on health systems in different countries and the high death rate in a short period. Many recent studies on cellular models and clinical trials have pointed out that hydroxychloroquine, a drug used in malaria, lupus and rheumatoid arthritis treatment, is a possib…

  Evaluation of potential therapeutically compounds for SARS-CoV-2: focus on estrogen-related compounds, autophagy modulators and ACE2, AP.R

• Abstract

  Many studies have shown the effects of estrogens in neuroprotection in neurodegenerative processes, such as in Alzheimer's Disease. Furthermore, modulation of autophagy is one of the promising strategies for the treatment of dementias associated with the formation of protein aggregates, which occur in Tauopathies, where the main component is the tau protein. However, the role of estrogens…

  Study of estrogen receptors mediated autophagy against tau toxicity in cell and zebrafish models, AP.JP

• Abstract

  Tauopathies comprise a group of neurodegenerative diseases characterized by the presence of tau protein aggregates, in which Alzheimer's Disease is the most prevalent and occurs more frequently in women. In this context, recent studies have demonstrated the neuroprotective role of estrogens and their antioxidant effect in models of oxidative stress, however, the action of estrogen analogs…

  Evaluation of estrogenic compounds in mitochondrial dysfunction and cellular metabolism in a tauopathy cell model, BP.IC
• Husbandry and handling of zebrafish model in a rack system, BP.TT

• Abstract

  At the beginning of 2020, the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) pandemic caused major impacts on the health systems in several countries, causing the death of a large number of people. Epidemiological data shows greater vulnerability in the elderly population, especially with pre-existing pathologies such as Diabetes, with a prevalence of deaths in male patients…

  Evaluation of estrogen-related compounds and autophagy modulators seeking for therapeutic targets against SARS-CoV-2, BP.PD

(Only some records are available in English at this moment)

• Abstract

  Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide. The neurobiological hallmarks of AD consist of extracellular amyloid plaques and intracellular neurofibrillary tangles, which are mainly formed by hyperphosphorylated tau. This hallmark strongly correlates with dementia and is therefore an interesting potential target for small molecules to modulate tau t…

  Evaluation of clinically-approved drugs to target tau toxicity in zebrafish model, BE.EP.PD