CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (2005), master's at Pharmacology from Universidade Federal de São Paulo (2008) and doctorate at Pharmacology from Universidade Federal de São Paulo (2012). Has experience in Pharmacology, focusing on Neuropsicopharmacology, acting on the following subjects: autofagia, sinalização de ca2+, apoptose, glutamato and microscopia confocal. (Source: Lattes Curriculum)
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The differential prevalence between genders is notable in neurodegenerative diseases, such as Alzheimer's disease (AD), and studies suggest that sex hormones play an important role in its pathophysiology. In AD and in other dementias, for example, intracellular inclusions of tau protein may be related to changes in processes such as autophagy and cellular metabolism. We have previously sh…
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus) pandemic has become a major global concern, mainly due to impacts on health systems in different countries and the high death rate in a short period. Many recent studies on cellular models and clinical trials have pointed out that hydroxychloroquine, a drug used in malaria, lupus and rheumatoid arthritis treatment, is a possib…
Many studies have shown the effects of estrogens in neuroprotection in neurodegenerative processes, such as in Alzheimer's Disease. Furthermore, modulation of autophagy is one of the promising strategies for the treatment of dementias associated with the formation of protein aggregates, which occur in Tauopathies, where the main component is the tau protein. However, the role of estrogens…
Tauopathies are neurodegenerative diseases characterized by decreased cognitive function, dementia, and in some cases there are changes in mobility. Alzheimer's disease presents both the amyloid component (²-amyloid aggregates) and the tauopathy, characterized by the atypical hyperphosphorylation of the tau protein, a cellular component that stabilizes microtubules, which in a pathologica…
Tauopathies comprise a group of neurodegenerative diseases characterized by the presence of tau protein aggregates, in which Alzheimer's Disease is the most prevalent and occurs more frequently in women. In this context, recent studies have demonstrated the neuroprotective role of estrogens and their antioxidant effect in models of oxidative stress, however, the action of estrogen analogs…
At the beginning of 2020, the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) pandemic caused major impacts on the health systems in several countries, causing the death of a large number of people. Epidemiological data shows greater vulnerability in the elderly population, especially with pre-existing pathologies such as Diabetes, with a prevalence of deaths in male patients…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide. The neurobiological hallmarks of AD consist of extracellular amyloid plaques and intracellular neurofibrillary tangles, which are mainly formed by hyperphosphorylated tau. This hallmark strongly correlates with dementia and is therefore an interesting potential target for small molecules to modulate tau t…
| 1 / 1 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 14 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 20 / 18 | All research grants and scholarships |
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