CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Technologist at Cell Cycle Lab of Butantan Institute. Researcher at the Biology Institute of the University of Campinas, in collaboration with CQMED and Eurofarma. Post Doctorate at the Biosciences Institute of the University of São Paulo. Post Doctorate at the University of Bergen, Norway. PhD in Tropical Diseases and International Health from the Institute of Tropical Medicine of São Paulo. Master of Science at the Faculty of Medicine of the University of São Paulo. Experience in the area of #8203;#8203;Parasitology, working mainly on the following topics: Leishmania, Trypanosome, next generation sequencing, transcriptomics, genomics, arginase, polyamines, tubecidin, nitrobenzylthioinosine, drug resistance, molecular characterization, drug testing, phenotypic assays, kinase inhibitors, cell cycle, DNA replication. (Source: Lattes Curriculum)
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Leishmania is auxotrophic for amino acids and nutrients and has a specific transport for L-arginine mediated by amino acid porter-3 (AAP3) inpromastigote and amastigote forms. This transporter is encoded in two copies in the parasite's genome, one of which is regulated by the presence of the amino acid itself, externally or internally, in addition to pH, temperature and parasite arginase …
The parasite belonging to Leishmania genus presents two main morphological forms during the life cycle. The promastigotes forms are extracellular, elongated and flagellated cells that proliferate in the digestive tract from the invertebrate host. The amastigotes forms are intracellular with non-apparent flagellum that proliferate in the mononuclear phagocytic system, being the macrophage …
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian hosts. This alternation involves environmental changes and submits the parasite to dynamic modifications in morphology, metabolism, cellular signaling and gene expression regulation to allow a rapid adaptation to new conditions. Our research group have been studying the role of arginas…
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