bachelor's at Ciências Biológicas Modalidade Médica from Universidade de Mogi das Cruzes (2004), master's at Ciências from Faculdade de Medicina da Universidade de São Paulo (2008) and doctorate at Doenças Tropicais from Instituto de Medicina Tropical de São Paulo (2013). Has experience in Parasitology, focusing on Human Parasite Protozoology, acting on the following subjects: leishmania, tubercidina, resistência, tratamento and super-expressão. (Source: Lattes Curriculum)
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Leishmania is auxotrophic for amino acids and nutrients and has a specific transport for L-arginine mediated by amino acid porter-3 (AAP3) inpromastigote and amastigote forms. This transporter is encoded in two copies in the parasite's genome, one of which is regulated by the presence of the amino acid itself, externally or internally, in addition to pH, temperature and parasite arginase …
The parasite belonging to Leishmania genus presents two main morphological forms during the life cycle. The promastigotes forms are extracellular, elongated and flagellated cells that proliferate in the digestive tract from the invertebrate host. The amastigotes forms are intracellular with non-apparent flagellum that proliferate in the mononuclear phagocytic system, being the macrophage …
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian hosts. This alternation involves environmental changes and submits the parasite to dynamic modifications in morphology, metabolism, cellular signaling and gene expression regulation to allow a rapid adaptation to new conditions. Our research group have been studying the role of arginas…
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CV Lattes
ORCID