DDS: graduate at Odontologia from Universidade Estadual Paulista Júlio de Mesquita Filho (1990), PhD. at Physiology from Universidade de São Paulo (1995) and ph.d. at Fisiologia from The University Of Iowa (1995). Has experience in Physiology, focusing on Cardiovascular Physiology, acting on the following subjects: núcleo do trato solitário, arterial pressure, blood pressure regulation, hypertension; hydrogen peroxide and blood pressure. (Source: Lattes Curriculum)
| Articles published in Pesquisa para Inovação FAPESP about the researcher: |
| Non-invasive sensor shows correlation between blood pressure and intracranial pressure |
| News published in Agência FAPESP Newsletter about the researcher |
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In this research project, we hypothesized that peripheral and central inflammation contributes to sympathetic activation and increase in blood pressure. This effect would be mediated by circulating pro-inflammatory cytokines which activate receptors within the carotid bodies, the organum vasculosum of the lamina terminalis (OVLT) and the subfornical organ (SFO), stimulating central sympat…
Cardiovascular diseases (CVDs) present the highest mortality rate in the world and hypertension is one of the main risk factors. Even considering the existing pharmacological strategies, one can still observe the high prevalence of CVDs. The renin-angiotensin system is an important regulator of cardiovascular functions and is involved in the development of several diseases related to this…
(Only some records are available in English at this moment)
Obesity and Hypertension are the leading cause of death in the world. Obesity and overweight contribute to elevated blood pressure in many patients with essential Hypertension. Experimental and clinical studies indicate that Visceral Obesity induces Hypertension by increasing renal sodium reabsorption through multiple mechanisms including activation of the Sympathetic Nervous System (SNS)…
Recent evidence has demonstrated that Renovascular Hypertension is characterized not only by an increase in sympathetic activity and activation of the renin-angiotensin-aldosterone system, but also by a peripheral inflammation with increased levels of circulating pro-inflammatory cytokines. Although the conventional therapeutic approaches for hypertension have targeted a reduction of symp…
Aldosterone is a mineralocorticoid produced by the suprarenal glands with several physiological functions including the regulation of blood electrolyte content and volume. Despite of the synthesis and release of aldosterone occurring during the hypovolemic state the most intense stimulus for its release is during hyperkalemia. Aldosterone acts by binding to the intracellular mineralocorti…
(Only some records are available in English at this moment)
The nervous and immune systems interact in a bidirectional manner, but the precise mechanisms governing this interplay are still unclear. Recently, we identified a previously unrecognized mechanism of neuroimmune interaction in which peripheral sensory organs (i.e., the carotid bodies) can detect the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) in the blood, activatin…
Water deprivation (WD) activates vasopressinergic neurons located in the hypothalamic supraoptic nucleus (SON) increasing the levels of vasopressin (VP) into the blood, which acts promoting vasoconstriction and urinary water retention. Previous studies have shown that neurons of SON express members of the cyclic nucleotide-gated family of ion channels like the hyperpolarization-activated …
Aldosterone is a mineralocorticoid produced by the suprarenal glands with several physiological functions including the modulation of blood pressure and the water-electrolyte content of the internal medium. The synthesis and release of aldosterone occur in the hypovolemic and especially in the hyperkalemic state. Aldosterone acts through interaction with the mineralocorticoid receptor (MR…
Renovascular hypertension affects 1 - 4% of the hypertensive population and it is the largest cause of secondary hypertension, affecting 25% to 35% of the patients with secondary hypertension. Renovascular hypertension is also called Goldblatt hypertension and is induced experimentally by unilateral stenosis of a renal artery, which decreases renal perfusion pressure leading to renin rele…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 26 / 19 | Completed research grants |
| 36 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 73 / 41 | All research grants and scholarships |
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