Graduation in Biological Sciences by the Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (1979), master in Physiology by the Universidade de São Paulo (1982) and Ph.D. by the Universidade de São Paulo (1984). Dr. Machado is Professor of Physiology and his line of investigation is currently oriented to the understanding of the synaptic transmission in the neural pathways of the central control of autonomic and respiratory functions and particularly in the coupling mechanisms of these important neuorvegetative functions at the brainstem level with focus on the modulation of the synaptic transmission by the astrocytes (http://machadolaboratory.wixsite.com/labweb). (Source: Lattes Curriculum)
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In the present project we will evaluate the impact of successive hypoxic challenges in the first 2 postnatal weeks of mice on the autonomic, cardiovascular and respiratory functions of these animals when they are 5-6 weeks old (juvenile). For this, female mice, immediately after giving birth, will be exposed together with their litters to the sustained hypoxia (SH) protocols for 5 days (P…
The main goal of this Thematic Project is to study the astrocytic modulation on the synaptic transmission of neurons integral to sympathetic and respiratory networks at the brainstem level under normoxic as well as in hypoxic conditions. This important and contemporary topic in the literature is associated to the role of astrocytes and their gliotransmitters on the modulation of synaptic …
The main goal of this Thematic Project is to study the astrocytic modulation on the synaptic transmission of neurons integral to sympathetic and respiratory networks at the brainstem level under normoxic as well as in hypoxic conditions. This important and contemporary topic in the literature is associated to the role of astrocytes and their gliotransmitters on the modulation of synaptic …
Synapses are the main functional element of the CNS and it has been recently described that some synapses present pre- and post-synaptic neurons involved by astrocytes, which are named tripartite synapse. There is an intense communication between astrocyte-neuron in tripartite synapse, which modulates the synaptic activity. Astrocytes express glutamate transporters that up take glutamate …
The neural mechanisms underlying the generation and modulation of the sympathetic outflow and the respiratory motor activities are essential for the physiological regulation of the cardiovascular and respiratory functions and consequently for the maintenance of the life. Changes in any aspect of these complex neural mechanisms may affect the cardiovascular and respiratory functions and ge…
Hypoxia is a possible physiological and pathophysiological situation that play a major role in the activation of the peripheral chemoreceptors, which produces the correspondent autonomic, respiratory and behavioural responses in arder to provide the system with the appropriated leveI of oxigen in the arterial blood. The acute chemoreflex activation produces the necessary increased in the …
(Only some records are available in English at this moment)
In this project we will evaluate the role of arterial chemoreceptors in development and maintenance of hypertension in renal hypertensive rats (1 kidney-1 clip) and spontaneously hypertensive rats (SHR). The peripheral chemoreceptors (carotid bodies) will be removed before the development or during the maintenance of renal hypertension. In SHR the deactivation of peripheral chemoreceptors…
Recent studies from our laboratory using C57BL/6 mice documented that sustained hypoxia (HM, FiO2 0.1 for 24h) induced significant changes in the respiratory pattern associated with an increase in the parasympathetic component. Previous studies from our laboratory, performed in rats, showed that glial/astrocyte cells in the ventral medulla are involved in the modulation of respiratory and…
Sustained hypoxia activate the peripheral chemoreceptors to produce autonomic and respiratory responses to bring back to normal the pressure of oxygen in the arterial blood. The first synapses of the afferents of the peripheral chemoreceptors are in the nucleus tractus solitarius (NTS). These synapses are involved by astrocytes and constitute the synpases tripartite. The interaction of as…
(Only some records are available in English at this moment)
In situations of sustained hypoxia (SH), peripheral chemoreceptors are stimulated and trigger autonomic and respiratory responses to bring the levels of O2 pressure in arterial blood back to normal. Stimulation of peripheral chemoreceptors, located in the carotid body, promotes the activation of neural endings whose afferents make the first synapse with neurons in the nucleus tractus soli…
In situations of sustained hypoxia (SH), peripheral chemoreceptors are stimulated and promote autonomic and respiratory responses to reestablish normal levels of O2 pressure in arterial blood. Stimulation of peripheral chemoreceptors, located in the carotid body, promotes the activation of neural endings whose afferents make the first synapse with neurons in the nucleus tractus solitarius…
(Only some records are available in English at this moment)
Hypoxic challenge can activate peripheral and central chemoreceptors and recruit brainstem sites directly involved with the generation/modulation of autonomic and respiratory functions in order to bring the PaO2 back to the normal level. Previous studies from our laboratory showed that C57BL/6 mice submitted to sustained hypoxia (SH, FiO2 0.1 for 24h) presented significant changes in the …
Rats submitted to Sustained hypoxia (SH - 24 h) presented increase in the excitatory synaptic transmission in the Nucleus Tractus Solitarius (NTS) neurons. SH is also associated with inflammation in the central nervous system. It is know that inflammatory mediators may act as neuromodulators facilitating excitatory goal transmission and changing the excitability of the neurons. Therefore,…
| 3 / 3 | Ongoing grants |
| 22 / 15 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 46 / 17 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 78 / 41 | All research grants and scholarships |
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